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Targeting of phosphorylated tau at threonine 181 by a Qβ virus-like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques.
Maphis NM, Hulse J, Peabody J, Dadras S, Whelpley MJ, Kandath M, Wilson C, Hobson S, Thompson J, Poolsup S, Beckman D, Ott SP, Watanabe JW, Usachenko JL, Van Rompay KK, Morrison J, Selwyn R, Rosenberg G, Knoefel J, Chackerian B, Bhaskar K. Maphis NM, et al. Among authors: chackerian b. Alzheimers Dement. 2025 Mar;21(3):e70101. doi: 10.1002/alz.70101. Alzheimers Dement. 2025. PMID: 40145301 Free PMC article.
A two-dose regimen of Qβ virus-like particle-based vaccines elicit protective antibodies against heroin and fentanyl.
Romano IG, Johnson-Weaver B, Core SB, Jamus AN, Brackeen M, Blough B, Dey S, Huang Y, Staats H, Wetsel WC, Chackerian B, Frietze KM. Romano IG, et al. Among authors: chackerian b. bioRxiv [Preprint]. 2024 Aug 29:2024.08.28.608988. doi: 10.1101/2024.08.28.608988. bioRxiv. 2024. Update in: NPJ Vaccines. 2025 Mar 28;10(1):57. doi: 10.1038/s41541-025-01105-0. PMID: 39257808 Free PMC article. Updated. Preprint.
96 results