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Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.
Wang Y, Wiesnoski DH, Helmink BA, Gopalakrishnan V, Choi K, DuPont HL, Jiang ZD, Abu-Sbeih H, Sanchez CA, Chang CC, Parra ER, Francisco-Cruz A, Raju GS, Stroehlein JR, Campbell MT, Gao J, Subudhi SK, Maru DM, Blando JM, Lazar AJ, Allison JP, Sharma P, Tetzlaff MT, Wargo JA, Jenq RR. Wang Y, et al. Nat Med. 2018 Dec;24(12):1804-1808. doi: 10.1038/s41591-018-0238-9. Epub 2018 Nov 12. Nat Med. 2018. PMID: 30420754 Free PMC article.
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells with …
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal mi
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.
Dubin K, Callahan MK, Ren B, Khanin R, Viale A, Ling L, No D, Gobourne A, Littmann E, Huttenhower C, Pamer EG, Wolchok JD. Dubin K, et al. Nat Commun. 2016 Feb 2;7:10391. doi: 10.1038/ncomms10391. Nat Commun. 2016. PMID: 26837003 Free PMC article.
Immunologic checkpoint blockade with ipilimumab, a monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) signalling, is associated with new-onset, immune-mediated colitis. ...We demonstrate that increased representation of bacte …
Immunologic checkpoint blockade with ipilimumab, a monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen-4 …
Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells.
Wang T, Zheng N, Luo Q, Jiang L, He B, Yuan X, Shen L. Wang T, et al. Front Immunol. 2019 Jun 4;10:1235. doi: 10.3389/fimmu.2019.01235. eCollection 2019. Front Immunol. 2019. PMID: 31214189 Free PMC article.
Immune checkpoint blockade (ICB) immunotherapy increases antitumor immunity by blocking cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4) or programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) and displays robust clinical responses in …
Immune checkpoint blockade (ICB) immunotherapy increases antitumor immunity by blocking cytotoxic-T-lymphocyte-associated prot …
Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment.
Lv J, Jia Y, Li J, Kuai W, Li Y, Guo F, Xu X, Zhao Z, Lv J, Li Z. Lv J, et al. Cell Death Dis. 2019 May 28;10(6):415. doi: 10.1038/s41419-019-1638-6. Cell Death Dis. 2019. PMID: 31138779 Free PMC article.
Gut microbiota analysis revealed that combination therapy with GQD and anti-mouse PD-1 significantly enriched for s__Bacteroides_acidifaciens and s__uncultured_organism_g__norank_f__Bacteroidales_S24-7_group. ...In addition, combination therapy with GQD and a …
Gut microbiota analysis revealed that combination therapy with GQD and anti-mouse PD-1 significantly enriched for s__Bacteroid …
Targeting tumor-resident mast cells for effective anti-melanoma immune responses.
Kaesler S, Wölbing F, Kempf WE, Skabytska Y, Köberle M, Volz T, Sinnberg T, Amaral T, Möckel S, Yazdi A, Metzler G, Schaller M, Hartmann K, Weide B, Garbe C, Rammensee HG, Röcken M, Biedermann T. Kaesler S, et al. JCI Insight. 2019 Oct 3;4(19):e125057. doi: 10.1172/jci.insight.125057. JCI Insight. 2019. PMID: 31578309 Free PMC article.
Immune checkpoint blockade has revolutionized cancer treatment. Patients developing immune mediated adverse events, such as colitis, appear to particularly benefit from immune checkpoint inhibition. ...We identified a systemic LPS signature in melanoma …
Immune checkpoint blockade has revolutionized cancer treatment. Patients developing immune mediated adverse events, such as …
The role of T cell trafficking in CTLA-4 blockade-induced gut immunopathology.
Zhang S, Liang W, Luo L, Sun S, Wang F. Zhang S, et al. BMC Biol. 2020 Mar 17;18(1):29. doi: 10.1186/s12915-020-00765-9. BMC Biol. 2020. PMID: 32183814 Free PMC article.
We found that blocking T cell homing increased colitis severity in the context of CTLA-4 blockade and that gut-trafficking blockade had different effects on different Th subsets and could facilitate the proliferation of Th17 cells in the lamina propria …
We found that blocking T cell homing increased colitis severity in the context of CTLA-4 blockade and that gut-traffick …
Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade.
Sun S, Luo L, Liang W, Yin Q, Guo J, Rush AM, Lv Z, Liang Q, Fischbach MA, Sonnenburg JL, Dodd D, Davis MM, Wang F. Sun S, et al. Proc Natl Acad Sci U S A. 2020 Oct 19:201921223. doi: 10.1073/pnas.1921223117. Online ahead of print. Proc Natl Acad Sci U S A. 2020. PMID: 33077598 Free article.
We found that Bifidobacterium altered the composition of the gut microbiota systematically in a regulatory T cell (Treg)-dependent manner. Moreover, this altered commensal community enhanced both the mitochondrial fitness and the IL-10-mediated suppressive functions …
We found that Bifidobacterium altered the composition of the gut microbiota systematically in a regulatory T cell (Treg)-depen …
Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade.
Wang F, Yin Q, Chen L, Davis MM. Wang F, et al. Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):157-161. doi: 10.1073/pnas.1712901115. Epub 2017 Dec 18. Proc Natl Acad Sci U S A. 2018. PMID: 29255057 Free PMC article.
To investigate this, we combined anti-CTLA-4 treatment with a standard colitis model to give mice a more severe form of the disease. Pretreatment with an antibiotic, vancomycin, provoked an even more severe, largely fatal form, suggesting that a Gram-positive component of …
To investigate this, we combined anti-CTLA-4 treatment with a standard colitis model to give mice a more severe form of the disease. …
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