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Therapeutic hypothermia for the treatment of acute myocardial infarction-combined analysis of the RAPID MI-ICE and the CHILL-MI trials.
Erlinge D, Götberg M, Noc M, Lang I, Holzer M, Clemmensen P, Jensen U, Metzler B, James S, Bøtker HE, Omerovic E, Koul S, Engblom H, Carlsson M, Arheden H, Östlund O, Wallentin L, Klos B, Harnek J, Olivecrona GK. Erlinge D, et al. Ther Hypothermia Temp Manag. 2015 Jun;5(2):77-84. doi: 10.1089/ther.2015.0009. Epub 2015 May 18. Ther Hypothermia Temp Manag. 2015. PMID: 25985169
Although significance was not achieved in CHILL-MI, in the pooled analysis IS/MaR was reduced in the hypothermia group, relative reduction (RR) 15% (40.5, 28.0-57.6 vs. 46.6, 36.8-63.8, p=0.046, median, interquartile range [IQR]). ...The prespecified pooled analysis …
Although significance was not achieved in CHILL-MI, in the pooled analysis IS/MaR was reduced in the hypothermia group, relati …
Gender but not diabetes, hypertension or smoking affects infarct evolution in ST-elevation myocardial infarction patients - data from the CHILL-MI, MITOCARE and SOCCER trials.
Nordlund D, Engblom H, Bonnet JL, Hansen HS, Atar D, Erlinge D, Ekelund U, Heiberg E, Carlsson M, Arheden H. Nordlund D, et al. BMC Cardiovasc Disord. 2019 Jul 3;19(1):161. doi: 10.1186/s12872-019-1139-7. BMC Cardiovasc Disord. 2019. PMID: 31269907 Free PMC article.
METHODS: Patients (n = 301) with first-time STEMI from the three recent multi-center trials (CHILL-MI, MITOCARE and SOCCER) underwent cardiac magnetic resonance (CMR) imaging to determine myocardium at risk (MaR) and infarct size (IS). ...
METHODS: Patients (n = 301) with first-time STEMI from the three recent multi-center trials (CHILL-MI, MITOCARE and SOCCER) un …
Proteomics in Hypothermia as Adjunctive Therapy in Patients with ST-Segment Elevation Myocardial Infarction: A CHILL-MI Substudy.
Mohammad MA, Noc M, Lang I, Holzer M, Clemmensen P, Jensen U, Metzler B, Erlinge D. Mohammad MA, et al. Ther Hypothermia Temp Manag. 2017 Sep;7(3):152-161. doi: 10.1089/ther.2016.0041. Epub 2017 Mar 2. Ther Hypothermia Temp Manag. 2017. PMID: 28437237 Clinical Trial.
In this explorative proteomic study from the randomized trial CHILL-MI, four biomarkers were identified as having reduced peak plasma values in patients with STEMI treated with therapeutic hypothermia as adjunctive therapy to PCI as compared with patients treated wi …
In this explorative proteomic study from the randomized trial CHILL-MI, four biomarkers were identified as having reduced peak …
Rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. The CHILL-MI trial: a randomized controlled study of the use of central venous catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction.
Erlinge D, Götberg M, Lang I, Holzer M, Noc M, Clemmensen P, Jensen U, Metzler B, James S, Bötker HE, Omerovic E, Engblom H, Carlsson M, Arheden H, Ostlund O, Wallentin L, Harnek J, Olivecrona GK. Erlinge D, et al. J Am Coll Cardiol. 2014 May 13;63(18):1857-65. doi: 10.1016/j.jacc.2013.12.027. Epub 2014 Feb 5. J Am Coll Cardiol. 2014. PMID: 24509284 Free article. Clinical Trial.
(Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction [CHILL-MI]; NCT01379261)....
(Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction [CHILL-MI …
Anterior STEMI associated with decreased strain in remote cardiac myocardium.
Sjögren H, Pahlm U, Engblom H, Erlinge D, Heiberg E, Arheden H, Carlsson M, Ostenfeld E. Sjögren H, et al. Int J Cardiovasc Imaging. 2022 Feb;38(2):375-387. doi: 10.1007/s10554-021-02391-0. Epub 2021 Sep 5. Int J Cardiovasc Imaging. 2022. PMID: 34482507 Free PMC article. Clinical Trial.
To assess (1) global longitudinal strain (GLS) by feature tracking cardiac magnetic resonance (CMR) in the sub-acute and chronic phases after ST-elevation infarction (STEMI) and compare to GLS in healthy controls, and (2) the evolution of GLS and regional longitudinal strain (RLS …
To assess (1) global longitudinal strain (GLS) by feature tracking cardiac magnetic resonance (CMR) in the sub-acute and chronic phases afte …
Sample Size in Clinical Cardioprotection Trials Using Myocardial Salvage Index, Infarct Size, or Biochemical Markers as Endpoint.
Engblom H, Heiberg E, Erlinge D, Jensen SE, Nordrehaug JE, Dubois-Randé JL, Halvorsen S, Hoffmann P, Koul S, Carlsson M, Atar D, Arheden H. Engblom H, et al. J Am Heart Assoc. 2016 Mar 9;5(3):e002708. doi: 10.1161/JAHA.115.002708. J Am Heart Assoc. 2016. PMID: 26961520 Free PMC article. Clinical Trial.
METHODS AND RESULTS: Controls (n=90) from the recent CHILL-MI and MITOCARE trials were included. MI size, MaR, and MSI were assessed from CMR. High-sensitivity troponin T (hsTnT) and creatine kinase isoenzyme MB (CKMB) levels were assessed in CHILL-MI …
METHODS AND RESULTS: Controls (n=90) from the recent CHILL-MI and MITOCARE trials were included. MI size, MaR, and MSI were as …
Evolution of left ventricular function among subjects with ST-elevation myocardial infarction after percutaneous coronary intervention.
Pahlm U, Ostenfeld E, Seemann F, Engblom H, Erlinge D, Heiberg E, Arheden H, Carlsson M. Pahlm U, et al. BMC Cardiovasc Disord. 2020 Jun 29;20(1):309. doi: 10.1186/s12872-020-01540-y. BMC Cardiovasc Disord. 2020. PMID: 32600336 Free PMC article. Clinical Trial.
METHODS: Healthy volunteers without cardiovascular disease and medication (controls, n = 20) and patients from the CHILL-MI study ( NCT01379261 ) prospectively underwent magnetic resonance imaging (MRI) 2-6 days and 6 months after STEMI (n = 77). CHILL-MI …
METHODS: Healthy volunteers without cardiovascular disease and medication (controls, n = 20) and patients from the CHILL-MI st …
Longitudinal left ventricular function is globally depressed within a week of STEMI.
Pahlm U, Seemann F, Engblom H, Gyllenhammar T, Halvorsen S, Hansen HS, Erlinge D, Atar D, Heiberg E, Arheden H, Carlsson M. Pahlm U, et al. Clin Physiol Funct Imaging. 2018 Apr 27. doi: 10.1111/cpf.12521. Online ahead of print. Clin Physiol Funct Imaging. 2018. PMID: 29701310
The aims were to determine the effect of ST-elevation myocardial infarction (STEMI) on AVPD and contribution of AVPD to SV and to study the relationship between AVPD and infarct size (IS) and location. Patients from CHILL-MI and MITOCARE studies with cardiovascular …
The aims were to determine the effect of ST-elevation myocardial infarction (STEMI) on AVPD and contribution of AVPD to SV and to study the …
Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction.
Mohammad MA, Koul S, Egerstedt A, Smith JG, Noc M, Lang I, Holzer M, Clemmensen P, Gidlöf O, Metzler B, Engstrøm T, Erlinge D. Mohammad MA, et al. Sci Rep. 2020 Oct 29;10(1):18663. doi: 10.1038/s41598-020-75399-6. Sci Rep. 2020. PMID: 33122738 Free PMC article. Clinical Trial.
We analysed 131 cardiovascular and inflammatory proteins using a multiplex proximity extension assay and blood samples obtained at baseline, 6, 24, and 96 h from the randomised clinical trial CHILL-MI. Cardiac magnetic resonance imaging data at 4 2 days and 6 months …
We analysed 131 cardiovascular and inflammatory proteins using a multiplex proximity extension assay and blood samples obtained at baseline, …
Automatic segmentation of myocardium at risk from contrast enhanced SSFP CMR: validation against expert readers and SPECT.
Tufvesson J, Carlsson M, Aletras AH, Engblom H, Deux JF, Koul S, Sörensson P, Pernow J, Atar D, Erlinge D, Arheden H, Heiberg E. Tufvesson J, et al. BMC Med Imaging. 2016 Mar 5;16:19. doi: 10.1186/s12880-016-0124-1. BMC Med Imaging. 2016. PMID: 26946139 Free PMC article. Clinical Trial.
Automatic segmentation was validated against manual delineation by expert readers in 183 patients with reperfused acute MI from two multi-center randomized clinical trials (RCT) (CHILL-MI and MITOCARE) and against myocardial perfusion SPECT in an additional set (n = …
Automatic segmentation was validated against manual delineation by expert readers in 183 patients with reperfused acute MI from two multi-ce …
13 results