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The Metabolism and Potential Bioactivity of Chlorophyll and Metallo-chlorophyll Derivatives in the Gastrointestinal Tract.
Zhong S, Bird A, Kopec RE. Zhong S, et al. Mol Nutr Food Res. 2021 Apr;65(7):e2000761. doi: 10.1002/mnfr.202000761. Epub 2021 Mar 1. Mol Nutr Food Res. 2021. PMID: 33548074 Review.
The basic porphyrin structure of chlorophyll binds magnesium in plants, but can bind different divalent metals (e.g., copper, zinc, iron) facilitated by food processing techniques and/or chemical synthesis. ...The review discusses what is understood about the abilit …
The basic porphyrin structure of chlorophyll binds magnesium in plants, but can bind different divalent metals (e.g., copper, …
Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay.
Dashwood RH, Breinholt V, Bailey GS. Dashwood RH, et al. Carcinogenesis. 1991 May;12(5):939-42. doi: 10.1093/carcin/12.5.939. Carcinogenesis. 1991. PMID: 1903094
Chlorophyllin (CHL), a sodium/copper derivative of chlorophyll, has been used to treat a number of human conditions with no toxic effects being reported. ...Chlorophyllin and AFB1 were coadministered in the diet, and carcinogen--DNA binding levels were …
Chlorophyllin (CHL), a sodium/copper derivative of chlorophyll, has been used to treat a number of human conditions with no to …
Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity.
Arimoto S, Fukuoka S, Itome C, Nakano H, Rai H, Hayatsu H. Arimoto S, et al. Mutat Res. 1993 Jun;287(2):293-305. doi: 10.1016/0027-5107(93)90022-8. Mutat Res. 1993. PMID: 7685489
Chlorophyllin is known to inhibit the mutagenicity of a variety of compounds. Using highly purified samples of chlorophyllin and its family compounds, we studied the mechanism of the inhibition. ...We concluded that trapping by complex formation plays a role in the …
Chlorophyllin is known to inhibit the mutagenicity of a variety of compounds. Using highly purified samples of chlorophyllin a …
Effects of chlorophyllin on transport of dibenzo(a, l)pyrene, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, and aflatoxin B(1) across Caco-2 cell monolayers.
Mata JE, Yu Z, Gray JE, Williams DE, Rodriguez-Proteau R. Mata JE, et al. Toxicology. 2004 Mar 1;196(1-2):117-25. doi: 10.1016/j.tox.2003.11.008. Toxicology. 2004. PMID: 15036761
Chlorophyllin (CHL) is a sodium copper derivative of chlorophyll that is capable of forming strong non-covalent complexes with several known carcinogens. ...Complexation studies revealed a higher binding affinity (K(b)) for DBP to CHL compared to AFB(1) to CH …
Chlorophyllin (CHL) is a sodium copper derivative of chlorophyll that is capable of forming strong non-covalent complexes with …
Green-Engineered Montmorillonite Clays for the Adsorption, Detoxification, and Mitigation of Aflatoxin B1 Toxicity.
Oladele JO, Xenophontos X, Elizondo GM 3rd, Daasari Y, Wang M, Tamamis P, Johnson NM, Phillips TD. Oladele JO, et al. Toxins (Basel). 2025 Mar 11;17(3):131. doi: 10.3390/toxins17030131. Toxins (Basel). 2025. PMID: 40137904 Free PMC article.
Studies have reported the coexistence of aflatoxins and other environmental toxins. This emphasizes the urgent need for efficient and effective mitigation strategies for aflatoxins. ...Therefore, this study sought to investigate the binding and detoxification …
Studies have reported the coexistence of aflatoxins and other environmental toxins. This emphasizes the urgent need for efficient and …
Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats.
Hasegawa R, Hirose M, Kato T, Hagiwara A, Boonyaphiphat P, Nagao M, Ito N, Shirai T. Hasegawa R, et al. Carcinogenesis. 1995 Sep;16(9):2243-6. doi: 10.1093/carcin/16.9.2243. Carcinogenesis. 1995. PMID: 7554083
Chlorophyll and chlorophyllin, a water-soluble salt of chlorophyll, have been reported to inhibit carcinogen-DNA binding and exert antimutagenic activity for some carcinogenic heterocyclic amines and aflatoxins. ...Female F344 rats were administ …
Chlorophyll and chlorophyllin, a water-soluble salt of chlorophyll, have been reported to inhibit carcinogen-DNA bin …