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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 1
1973 1
1975 2
1976 5
1978 3
1979 3
1980 6
1981 7
1982 7
1983 8
1984 11
1985 13
1986 17
1987 11
1988 9
1989 7
1990 18
1991 11
1992 14
1993 10
1994 10
1995 9
1996 6
1997 8
1998 8
2000 5
2001 6
2002 7
2003 9
2004 8
2005 5
2006 7
2007 4
2008 8
2009 9
2010 4
2011 7
2012 15
2013 7
2014 10
2015 8
2016 13
2017 15
2018 13
2019 7
2020 4
2021 9
2022 14
2023 7
2024 2

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395 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events.
Ishani A, Cushman WC, Leatherman SM, Lew RA, Woods P, Glassman PA, Taylor AA, Hau C, Klint A, Huang GD, Brophy MT, Fiore LD, Ferguson RE; Diuretic Comparison Project Writing Group. Ishani A, et al. N Engl J Med. 2022 Dec 29;387(26):2401-2410. doi: 10.1056/NEJMoa2212270. Epub 2022 Dec 14. N Engl J Med. 2022. PMID: 36516076 Clinical Trial.
BACKGROUND: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear. ...There were no between-group differences in the occurrence of any of the components of the primary outcome. …
BACKGROUND: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients …
Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease.
Agarwal R, Sinha AD, Cramer AE, Balmes-Fenwick M, Dickinson JH, Ouyang F, Tu W. Agarwal R, et al. N Engl J Med. 2021 Dec 30;385(27):2507-2519. doi: 10.1056/NEJMoa2110730. Epub 2021 Nov 5. N Engl J Med. 2021. PMID: 34739197 Free PMC article. Clinical Trial.
The percent change in the urinary albumin-to-creatinine ratio from baseline to 12 weeks was lower in the chlorthalidone group than in the placebo group by 50 percentage points (95% CI, 37 to 60). Hypokalemia, reversible increases in serum creatinine level, hyperglycemia, d …
The percent change in the urinary albumin-to-creatinine ratio from baseline to 12 weeks was lower in the chlorthalidone group than in …
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. JAMA. 2002 Dec 18;288(23):2981-97. doi: 10.1001/jama.288.23.2981. JAMA. 2002. PMID: 12479763 Clinical Trial.
INTERVENTIONS: Participants were randomly assigned to receive chlorthalidone, 12.5 to 25 mg/d (n = 15 255); amlodipine, 2.5 to 10 mg/d (n = 9048); or lisinopril, 10 to 40 mg/d (n = 9054) for planned follow-up of approximately 4 to 8 years. ...For amlodipine vs chlorthal
INTERVENTIONS: Participants were randomly assigned to receive chlorthalidone, 12.5 to 25 mg/d (n = 15 255); amlodipine, 2.5 to 10 mg/ …
Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects.
Roush GC, Ernst ME, Kostis JB, Tandon S, Sica DA. Roush GC, et al. Hypertension. 2015 May;65(5):1041-6. doi: 10.1161/HYPERTENSIONAHA.114.05021. Epub 2015 Mar 2. Hypertension. 2015. PMID: 25733245 Review.
Hydrochlorothiazide (HCTZ) has often been contrasted with chlorthalidone, but relatively little is known about HCTZ versus indapamide (INDAP). ...In conclusion, these head-to-head comparisons demonstrate that, like chlorthalidone, INDAP is more potent than HCTZ at c …
Hydrochlorothiazide (HCTZ) has often been contrasted with chlorthalidone, but relatively little is known about HCTZ versus indapamide …
Pharmacological interventions for asymptomatic carotid stenosis.
Clezar CN, Flumignan CD, Cassola N, Nakano LC, Trevisani VF, Flumignan RL. Clezar CN, et al. Cochrane Database Syst Rev. 2023 Aug 4;8(8):CD013573. doi: 10.1002/14651858.CD013573.pub2. Cochrane Database Syst Rev. 2023. PMID: 37565307 Review.
The study did not measure neurological impairment or quality of life. Antihypertensive agents (metoprolol and chlorthalidone) versus placebo The antihypertensive agent, metoprolol, may result in no difference in ipsilateral major or disabling stroke (RR 0.14, 95% CI 0.02 t …
The study did not measure neurological impairment or quality of life. Antihypertensive agents (metoprolol and chlorthalidone) versus …
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
[No authors listed] [No authors listed] JAMA. 1991 Jun 26;265(24):3255-64. JAMA. 1991. PMID: 2046107 Clinical Trial.
INTERVENTIONS: --Participants were stratified by clinical center and by antihypertensive medication status at initial contact. For step 1 of the trial, dose 1 was chlorthalidone, 12.5 mg/d, or matching placebo; dose 2 was 25 mg/d. For step 2, dose 1 was atenolol, 25 mg/d, …
INTERVENTIONS: --Participants were stratified by clinical center and by antihypertensive medication status at initial contact. For step 1 of …
New wrinkles in hypertension management 2022.
Carey RM, Whelton PK. Carey RM, et al. Curr Opin Cardiol. 2022 Jul 1;37(4):317-325. doi: 10.1097/HCO.0000000000000980. Curr Opin Cardiol. 2022. PMID: 35731676 Free PMC article. Review.
In patients with stage 4 renal disease, the thiazide-like diuretic chlorthalidone (as add-on therapy) lowered BP markedly compared with placebo. ...
In patients with stage 4 renal disease, the thiazide-like diuretic chlorthalidone (as add-on therapy) lowered BP markedly compared wi …
Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial.
Collier DJ, Juhasz A, Agabiti-Rosei E, Lloyd E, Hisada M, Zhao L, Kupfer S, Caulfield MJ. Collier DJ, et al. J Clin Hypertens (Greenwich). 2018 Oct;20(10):1473-1484. doi: 10.1111/jch.13376. Epub 2018 Oct 9. J Clin Hypertens (Greenwich). 2018. PMID: 30302936 Free PMC article. Clinical Trial.
"Nonresponders" were then randomized to 8 weeks of double-blind treatment with AZL-M 40 mg, AZL-M/chlortalidone (CLD) 40/25, or AZL-M/CLD 40/12.5 mg. After 8 weeks, mean clinic SBP change was -21.1 (1.04) mm Hg for AZL-M/CLD 40/25 mg, -15.8 (1.08) mm Hg for AZL-M/CLD 40/12 …
"Nonresponders" were then randomized to 8 weeks of double-blind treatment with AZL-M 40 mg, AZL-M/chlortalidone (CLD) 40/25, or AZL-M …
Efficacy and safety of standard dose triple combination of telmisartan 80 mg/amlodipine 5 mg/chlorthalidone 25 mg in primary hypertension: A randomized, double-blind, active-controlled, multicenter phase 3 trial.
Cho EJ, Kim MH, Kim YH, Chang K, Choi DJ, Kang WC, Shin J, Kim SH, Lee N, Son JW, Doh JH, Kim WS, Hong SJ, Rhee MY, Ahn Y, Lim SW, Hong SP, Choi SY, Hyon MS, Hwang JY, Kwon K, Cha KS, Ihm SH, Lee JH, Yoo BS, Kim HS. Cho EJ, et al. J Clin Hypertens (Greenwich). 2023 Sep;25(9):817-827. doi: 10.1111/jch.14707. Epub 2023 Aug 23. J Clin Hypertens (Greenwich). 2023. PMID: 37614053 Free PMC article. Clinical Trial.
The authors evaluated the efficacy, safety, and characteristics of patients who respond well to standard dose triple combination therapy including chlorthalidone 25 mg with telmisartan 80 mg plus amlodipine 5 mg in hypertensive patients. ...Patients are randomized to tripl …
The authors evaluated the efficacy, safety, and characteristics of patients who respond well to standard dose triple combination therapy inc …
Antioxidative effects of thiazide diuretics in refractory hypertensive patients. A randomized crossover trial of chlortalidone and trichlormethiazide.
Sato K, Dohi Y, Kojima M, Takase H, Suzuki S, Ito S. Sato K, et al. Arzneimittelforschung. 2010;60(10):612-6. doi: 10.1055/s-0031-1296334. Arzneimittelforschung. 2010. PMID: 21125811 Clinical Trial.
Although many large-scale clinical trials on hypertension have proved that thiazide diuretics confer significant reductions in stroke and cardiovascular events, most of these trials preferentially used chlortalidone. Therefore, the difference in antioxidant effects between …
Although many large-scale clinical trials on hypertension have proved that thiazide diuretics confer significant reductions in stroke and ca …
395 results