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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1998 1
1999 1
2002 2
2003 1
2004 1
2005 3
2006 2
2007 4
2008 5
2009 3
2010 12
2011 18
2012 26
2013 47
2014 55
2015 101
2016 127
2017 182
2018 212
2019 298
2020 403
2021 449
2022 282
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1,987 results
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Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake.
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, Pasolli E, Rivellese A, Dragsted LO, Vitaglione P, Ehrlich SD, Ercolini D. Meslier V, et al. Gut. 2020 Jul;69(7):1258-1268. doi: 10.1136/gutjnl-2019-320438. Epub 2020 Feb 19. Gut. 2020. PMID: 32075887 Free PMC article. Clinical Trial.
Shotgun metagenomics showed gut microbiome changes that reflected individual MD adherence and increase in gene richness in participants who reduced systemic inflammation over the intervention. ...CONCLUSION: Switching subjects to an MD while maintaining their energy intake …
Shotgun metagenomics showed gut microbiome changes that reflected individual MD adherence and increase in gene richness in participan …
Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites.
Zhang X, Coker OO, Chu ES, Fu K, Lau HCH, Wang YX, Chan AWH, Wei H, Yang X, Sung JJY, Yu J. Zhang X, et al. Gut. 2021 Apr;70(4):761-774. doi: 10.1136/gutjnl-2019-319664. Epub 2020 Jul 21. Gut. 2021. PMID: 32694178 Free PMC article.
Cholesterol-induced NAFLD-HCC formation was associated with gut microbiota dysbiosis. ...Cholesterol inhibitory therapy and gut microbiota manipulation may be effective strategies for NAFLD-HCC prevention....
Cholesterol-induced NAFLD-HCC formation was associated with gut microbiota dysbiosis. ...Cholesterol inhibitory therapy
An update on the pathogenesis of cholesterol gallstone disease.
Di Ciaula A, Wang DQ, Portincasa P. Di Ciaula A, et al. Curr Opin Gastroenterol. 2018 Mar;34(2):71-80. doi: 10.1097/MOG.0000000000000423. Curr Opin Gastroenterol. 2018. PMID: 29283909 Free PMC article. Review.
PURPOSE OF REVIEW: Gallstone disease is a major epidemiologic and economic burden worldwide, and the most frequent form is cholesterol gallstone disease. RECENT FINDINGS: Major pathogenetic factors for cholesterol gallstones include a genetic background, hepatic hyp …
PURPOSE OF REVIEW: Gallstone disease is a major epidemiologic and economic burden worldwide, and the most frequent form is cholesterol
The Microbiome Revolution Turns to Cholesterol.
Redinbo MR. Redinbo MR. Cell Host Microbe. 2020 Aug 12;28(2):154-156. doi: 10.1016/j.chom.2020.07.011. Cell Host Microbe. 2020. PMID: 32791107 Free article.
The story of twentieth century biomedical breakthroughs could be told through cholesterol. Revolutions in genetics, molecular biology, genomics, and antibody-based therapies defined cholesterol's impact on human health and cholesterol-lowering strategi …
The story of twentieth century biomedical breakthroughs could be told through cholesterol. Revolutions in genetics, molecular biology …
The intestinal microbiota regulates host cholesterol homeostasis.
Le Roy T, Lécuyer E, Chassaing B, Rhimi M, Lhomme M, Boudebbouze S, Ichou F, Haro Barceló J, Huby T, Guerin M, Giral P, Maguin E, Kapel N, Gérard P, Clément K, Lesnik P. Le Roy T, et al. BMC Biol. 2019 Nov 27;17(1):94. doi: 10.1186/s12915-019-0715-8. BMC Biol. 2019. PMID: 31775890 Free PMC article.
The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. ...Measurement of plasma cholesterol levels as well as cholesterol synthesis and fluxes by complementary approaches showed …
The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism sca …
Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.
Kenny DJ, Plichta DR, Shungin D, Koppel N, Hall AB, Fu B, Vasan RS, Shaw SY, Vlamakis H, Balskus EP, Xavier RJ. Kenny DJ, et al. Cell Host Microbe. 2020 Aug 12;28(2):245-257.e6. doi: 10.1016/j.chom.2020.05.013. Epub 2020 Jun 15. Cell Host Microbe. 2020. PMID: 32544460 Free PMC article.
Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification of functional enzymes and microbes. ...Thus, cholesterol metabolism by these microbes may play import …
Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a f …
Bile acids and the gut microbiome.
Ridlon JM, Kang DJ, Hylemon PB, Bajaj JS. Ridlon JM, et al. Curr Opin Gastroenterol. 2014 May;30(3):332-8. doi: 10.1097/MOG.0000000000000057. Curr Opin Gastroenterol. 2014. PMID: 24625896 Free PMC article. Review.
Recent studies have shown potential mechanisms explaining how perturbations in the microbiome affect bile acid pool size and composition. Bile acids are emerging as regulators of the gut microbiome at the highest taxonomic levels. ...Diet, antibiotic therapy, and di …
Recent studies have shown potential mechanisms explaining how perturbations in the microbiome affect bile acid pool size and composit …
Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis.
Chen PB, Black AS, Sobel AL, Zhao Y, Mukherjee P, Molparia B, Moore NE, Aleman Muench GR, Wu J, Chen W, Pinto AFM, Maryanoff BE, Saghatelian A, Soroosh P, Torkamani A, Leman LJ, Ghadiri MR. Chen PB, et al. Nat Biotechnol. 2020 Nov;38(11):1288-1297. doi: 10.1038/s41587-020-0549-5. Epub 2020 Jun 15. Nat Biotechnol. 2020. PMID: 32541956 Free PMC article.
This approach was used to identify cyclic D,L-alpha-peptides that remodeled the Western diet (WD) gut microbiome toward the low-fat-diet microbiome state. Daily oral administration of the peptides in WD-fed LDLr(-/-) mice reduced plasma total cholesterol leve …
This approach was used to identify cyclic D,L-alpha-peptides that remodeled the Western diet (WD) gut microbiome toward the low-fat-d …
The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis.
Vourakis M, Mayer G, Rousseau G. Vourakis M, et al. Int J Mol Sci. 2021 Jul 28;22(15):8074. doi: 10.3390/ijms22158074. Int J Mol Sci. 2021. PMID: 34360839 Free PMC article. Review.
In this review, the mechanisms of microbial derived metabolites such as primary and secondary bile acids (BAs), trimethylamine N-oxide (TMAO), and short-chain fatty acids (SCFAs) will be explored in the context of cholesterol metabolism. These metabolites play critical rol …
In this review, the mechanisms of microbial derived metabolites such as primary and secondary bile acids (BAs), trimethylamine N-oxide (TMAO …
Resveratrol, Metabolic Syndrome, and Gut Microbiota.
Chaplin A, Carpéné C, Mercader J. Chaplin A, et al. Nutrients. 2018 Nov 3;10(11):1651. doi: 10.3390/nu10111651. Nutrients. 2018. PMID: 30400297 Free PMC article. Review.
Clinical trials have been carried out to address its potential; however, results are still inconclusive. Even though resveratrol is partly metabolized by gut microbiota, the relevance of this "forgotten organ" had not been widely considered. However, in the past few years, …
Clinical trials have been carried out to address its potential; however, results are still inconclusive. Even though resveratrol is partly m …
1,987 results