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Cholestyramine protection against ochratoxin A toxicity: role of ochratoxin A sorption by the resin and bile acid enterohepatic circulation.
Kerkadi A, Barriault C, Marquardt RR, Frohlich AA, Yousef IM, Zhu XX, Tuchweber B. Kerkadi A, et al. J Food Prot. 1999 Dec;62(12):1461-5. doi: 10.4315/0362-028x-62.12.1461. J Food Prot. 1999. PMID: 10606152
We have shown that the addition of cholestyramine (CHA, a resin known to bind bile salts in the gastrointestinal tract) to ochratoxin A (OTA)-contaminated rat diets reduced plasma levels of the toxin and prevented OTA-induced nephrotoxicity. ...At 1 mM concen …
We have shown that the addition of cholestyramine (CHA, a resin known to bind bile salts in the gastrointestinal tract) to …
Effect of dietary cholestyramine on the elimination pattern of ochratoxin A in rats.
Madhyastha MS, Frohlich AA, Marquardt RR. Madhyastha MS, et al. Food Chem Toxicol. 1992 Aug;30(8):709-14. doi: 10.1016/0278-6915(92)90167-j. Food Chem Toxicol. 1992. PMID: 1398352
Three experiments with rats established the effects of dietary cholestyramine on the disposition of ochratoxin A (OA) and its hydrolysed metabolite, alpha-ochratoxin (O alpha). In the first experiment OA (1 mg/kg) was incorporated into a diet that contained 0 …
Three experiments with rats established the effects of dietary cholestyramine on the disposition of ochratoxin A (OA) and its …
Dietary cholestyramine reduces ochratoxin A-induced nephrotoxicity in the rat by decreasing plasma levels and enhancing fecal excretion of the toxin.
Kerkadi A, Barriault C, Tuchweber B, Frohlich AA, Marquardt RR, Bouchard G, Yousef IM. Kerkadi A, et al. J Toxicol Environ Health A. 1998 Feb 6;53(3):231-50. doi: 10.1080/009841098159367. J Toxicol Environ Health A. 1998. PMID: 9482354
Several methods have been tested to reduce the toxicity of OTA in animals but with limited success. In rats, the effect of cholestyramine (CHA), a bile acid-binding resin, was investigated on OTA-induced nephrotoxicity and bioavailability. ...At 1 and 3 ppm of OTA i …
Several methods have been tested to reduce the toxicity of OTA in animals but with limited success. In rats, the effect of cholestyramine
A review of the diagnosis and treatment of Ochratoxin A inhalational exposure associated with human illness and kidney disease including focal segmental glomerulosclerosis.
Hope JH, Hope BE. Hope JH, et al. J Environ Public Health. 2012;2012:835059. doi: 10.1155/2012/835059. Epub 2011 Dec 29. J Environ Public Health. 2012. PMID: 22253638 Free PMC article. Review.
Ochratoxin A (OTA) exposure via ingestion and inhalation has been described in the literature to cause kidney disease in both animals and humans. ...Prevention and treatment strategies for OTA-induced illness are also discussed, including cholestyramine, a bile-acid
Ochratoxin A (OTA) exposure via ingestion and inhalation has been described in the literature to cause kidney disease in both animals
Prevention of nephrotoxicity of ochratoxin A, a food contaminant.
Creppy EE, Baudrimont I, Betbeder AM. Creppy EE, et al. Toxicol Lett. 1995 Dec;82-83:869-77. doi: 10.1016/0378-4274(95)03601-6. Toxicol Lett. 1995. PMID: 8597155 Review.
Ochratoxin A (OTA) is a mycotoxin produced by ubiquitous Aspergilli, mainly by Aspergillus ochraceus and also by Penicilium verrucosum. ...Some enzymes such as superoxide dismutase (SOD) and catalase, radical scavengers, vitamins, prostaglandin (PG) synthesis inhibitors, (
Ochratoxin A (OTA) is a mycotoxin produced by ubiquitous Aspergilli, mainly by Aspergillus ochraceus and also by Penicilium verrucosu
Evidence for an enterohepatic circulation of ochratoxin A in mice.
Roth A, Chakor K, Creppy EE, Kane A, Roschenthaler R, Dirheimer G. Roth A, et al. Toxicology. 1988 Mar;48(3):293-308. doi: 10.1016/0300-483x(88)90110-2. Toxicology. 1988. PMID: 3344528
The distribution and elimination of [3H]ochratoxin A (OTA) from stomach content and tissue, intestine content and tissue, liver, bile, serum and urine of Swiss male mice which had received a single low dose of OTA by intubation was followed as a function of time. ...When g …
The distribution and elimination of [3H]ochratoxin A (OTA) from stomach content and tissue, intestine content and tissue, liver, bile …
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