Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
1992 1
1993 1
2003 1
2008 3
2009 3
2012 2
2013 2
2014 2
2015 3
2016 1
2017 2
2018 1
2019 1
2021 2
2022 2
2023 2
2024 7
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

36 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial.
Lee W, Kim M. Lee W, et al. Medicine (Baltimore). 2024 Jun 14;103(24):e38067. doi: 10.1097/MD.0000000000038067. Medicine (Baltimore). 2024. PMID: 38875437 Free PMC article. Clinical Trial.
BACKGROUND: Choline alfoscerate (alpha-glycerylphosphorylcholine) is a phospholipid that includes choline, which increases the release of acetylcholine. The ASCOMALVA trial, a combination of donepezil and choline alfoscerate, slowed cogni …
BACKGROUND: Choline alfoscerate (alpha-glycerylphosphorylcholine) is a phospholipid that includes choline, which …
Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis.
Sagaro GG, Traini E, Amenta F. Sagaro GG, et al. J Alzheimers Dis. 2023;92(1):59-70. doi: 10.3233/JAD-221189. J Alzheimers Dis. 2023. PMID: 36683513 Free PMC article.
BACKGROUND: Choline alphoscerate (alpha glyceryl phosphorylcholine, alpha-GPC) is a choline-containing phospholipid used as a medicine or nutraceutical to improve cognitive function impairment occurring in neurological conditions including adult-onset dementia disor …
BACKGROUND: Choline alphoscerate (alpha glyceryl phosphorylcholine, alpha-GPC) is a choline-containing phospholipid used as a …
Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
Sohn M, Park YH, Lim S. Sohn M, et al. Diabetes Obes Metab. 2025 Mar;27(3):1350-1358. doi: 10.1111/dom.16131. Epub 2024 Dec 20. Diabetes Obes Metab. 2025. PMID: 39703111 Clinical Trial.
AIMS: This study evaluated the effects of choline alfoscerate on cognitive function and quality of life in T2DM patients with mild cognitive decrements. ...Physical health, as measured by the SF-36 survey, was significantly better in the choline alfoscerat …
AIMS: This study evaluated the effects of choline alfoscerate on cognitive function and quality of life in T2DM patients with …
Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers.
Min MH, Park JH, Hur JH, Shin HC, Cho Y, Kim DD. Min MH, et al. Drug Des Devel Ther. 2019 Apr 5;13:1049-1058. doi: 10.2147/DDDT.S193424. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31040642 Free PMC article. Clinical Trial.
Subjects were orally treated with 1,200 mg of test or reference choline alfoscerate (400 mg three doses) formulation. Blood samples were collected up to 12 hours the day before dosing to correct the baseline level of choline and 12 hours after dosing to obtai …
Subjects were orally treated with 1,200 mg of test or reference choline alfoscerate (400 mg three doses) formulation. Blood sa …
[Efficacy and safety of choline alfoscerate in the preventive therapy of dementia in elderly patients with Mild Cognitive Impairment: a three-year prospective comparative study].
Ponomareva EV, Androsova LV, Krinsky SA, Gavrilova SI. Ponomareva EV, et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(4. Vyp. 2):92-99. doi: 10.17116/jnevro202412404292. Zh Nevrol Psikhiatr Im S S Korsakova. 2024. PMID: 38696157 Clinical Trial. Russian.
OBJECTIVE: To study the efficacy and safety of the use of annual course therapy of choline alfoscerate (CA) as a drug potentially capable of slowing or preventing the transition of amnesic type mild cognitive impairment (aMCI) into clinically pronounced dementia in …
OBJECTIVE: To study the efficacy and safety of the use of annual course therapy of choline alfoscerate (CA) as a drug potentia …
Efficacy and safety of choline alphoscerate for amnestic mild cognitive impairment: a randomized double-blind placebo-controlled trial.
Jeon J, Lee SY, Lee S, Han C, Park GD, Kim SJ, Chang JG, Kim WJ. Jeon J, et al. BMC Geriatr. 2024 Sep 19;24(1):774. doi: 10.1186/s12877-024-05366-7. BMC Geriatr. 2024. PMID: 39300341 Free PMC article. Clinical Trial.
BACKGROUND: Effective interventions for overall healthy subjects with mild cognitive impairment are currently limited. Choline alphoscerate (alpha glyceryl phosphorylcholine, alphaGPC) is a choline-containing phospholipid used to treat cognitive function impairments …
BACKGROUND: Effective interventions for overall healthy subjects with mild cognitive impairment are currently limited. Choline alphos …
Effect of Treatment of the Cholinergic Precursor Choline Alphoscerate in Mild Cognitive Dysfunction: A Randomized Controlled Trial.
Carotenuto A, Andreone V, Amenta F, Traini E. Carotenuto A, et al. Medicina (Kaunas). 2024 Jun 1;60(6):925. doi: 10.3390/medicina60060925. Medicina (Kaunas). 2024. PMID: 38929542 Free PMC article. Clinical Trial.
This study intends to evaluate the efficacy of choline alphoscerate in patients with mild cognitive impairment (MCI) and associated vascular damage, in stabilizing and/or slowing brain atrophy typical of adult-onset cognitive dysfunction, and in improving and/or slowing th …
This study intends to evaluate the efficacy of choline alphoscerate in patients with mild cognitive impairment (MCI) and associated v …
Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
De Jesus Moreno Moreno M. De Jesus Moreno Moreno M. Clin Ther. 2003 Jan;25(1):178-93. doi: 10.1016/s0149-2918(03)90023-3. Clin Ther. 2003. PMID: 12637119 Clinical Trial.
Despite encouraging early results, well-controlled clinical trials did not confirm a clinical utility of cholinergic precursors such as choline and lecithin (phosphatidylcholine) in AD. OBJECTIVE: This study assessed the efficacy and tolerability of the cholinergic precurs …
Despite encouraging early results, well-controlled clinical trials did not confirm a clinical utility of cholinergic precursors such as c …
36 results