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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1940 1
1945 1
1947 4
1948 2
1949 3
1950 1
1951 2
1952 3
1953 5
1954 6
1955 6
1956 1
1957 9
1958 1
1959 1
1960 5
1961 5
1962 4
1963 3
1964 7
1965 10
1966 9
1967 13
1968 11
1969 24
1970 12
1971 13
1972 6
1973 20
1974 16
1975 21
1976 16
1977 9
1978 16
1979 13
1980 22
1981 18
1982 23
1983 21
1984 19
1985 33
1986 30
1987 26
1988 21
1989 40
1990 34
1991 28
1992 33
1993 34
1994 26
1995 36
1996 31
1997 35
1998 33
1999 24
2000 34
2001 19
2002 36
2003 37
2004 45
2005 43
2006 73
2007 85
2008 83
2009 90
2010 100
2011 93
2012 114
2013 110
2014 124
2015 132
2016 140
2017 157
2018 148
2019 162
2020 205
2021 207
2022 201
2023 217
2024 218
2025 232
2026 50

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3,581 results

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Page 1
Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity.
Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, Guan KL, Xiong Y, Liu J, Yuan HX. Li X, et al. Liver Int. 2020 Jun;40(6):1378-1394. doi: 10.1111/liv.14428. Epub 2020 Mar 20. Liver Int. 2020. PMID: 32145145
Importantly, ferroptosis inhibitors alleviated MCD-diet induced inflammation, fibrogenesis and liver injury. Finally, lipid ROS promotes liver steatosis by boosting lipid droplets formation. CONCLUSION: Our results demonstrate an important role of ferroptosis in the progre …
Importantly, ferroptosis inhibitors alleviated MCD-diet induced inflammation, fibrogenesis and liver injury. Finally, lipid ROS promo …
A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet.
Alshawsh MA, Alsalahi A, Alshehade SA, Saghir SAM, Ahmeda AF, Al Zarzour RH, Mahmoud AM. Alshawsh MA, et al. Molecules. 2022 Jan 27;27(3):858. doi: 10.3390/molecules27030858. Molecules. 2022. PMID: 35164140 Free PMC article. Review.
However, no reproducible experimental animal model displays the full spectrum of pathophysiological, histological, molecular, and clinical features associated with human NAFLD/NASH progression. Although methionine-choline-deficient (MCD) diet and high-fat …
However, no reproducible experimental animal model displays the full spectrum of pathophysiological, histological, molecular, and clinical f …
Choline-deficient Diet-induced NAFLD Animal Model Recaptures Core Human Pathophysiology With Similar Gene Co-expression Networks.
Ishigure T, Sasase T, Tohma M, Uno K, Toriniwa Y, Saito T, Saigo Y, Edamura K, Miyajima K, Ohta T. Ishigure T, et al. In Vivo. 2023 Jul-Aug;37(4):1517-1531. doi: 10.21873/invivo.13237. In Vivo. 2023. PMID: 37369510 Free PMC article.
MATERIALS AND METHODS: We performed weighted gene co-expression network analysis of liver tissues from a choline-deficient L-amino acid-defined (CDAA) diet-induced NAFLD animal model. In addition, module preservation analysis was conducted to evaluate similar …
MATERIALS AND METHODS: We performed weighted gene co-expression network analysis of liver tissues from a choline-deficient L-a …
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages.
Liu MT, Zhang Y, Xiang CG, Yang T, Wang XH, Lu QK, Lu HM, Fan C, Feng CL, Yang XQ, Zou DW, Li H, Tang W. Liu MT, et al. Acta Pharmacol Sin. 2024 Sep;45(9):1912-1925. doi: 10.1038/s41401-024-01291-y. Epub 2024 Apr 29. Acta Pharmacol Sin. 2024. PMID: 38684800 Free PMC article.
Liver dysfunction and abnormal level of liver metabolism indices were identified in UC patients, suggesting a close interaction between gut and liver disorders. Methionine-choline deficient diet (MCD) has been shown to induce persistent alterations of gut mic …
Liver dysfunction and abnormal level of liver metabolism indices were identified in UC patients, suggesting a close interaction between gut …
Choline-deficient, high-fat diet-induced MASH in Gottingen Minipigs: characterization and effects of a chow reversal period.
Hvid H, Hjuler ST, Bedossa P, Tiniakos DG, Kamzolas I, Harder LM, Xue Y, Perfield JW, Kirk RK, Latta M, Mikkelsen LF, Pedersen HD; LITMUS Investigators. Hvid H, et al. Am J Physiol Gastrointest Liver Physiol. 2024 Oct 1;327(4):G571-G585. doi: 10.1152/ajpgi.00120.2024. Epub 2024 Jul 23. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 39041677 Free PMC article.
The physiology and metabolism of pigs have a relatively high resemblance to humans, and the present study aimed to characterize choline-deficient and high-fat diet (CDAHFD)-fed Gottingen Minipigs as a novel animal model of MASLD/MASH. ...Furthermore, changes …
The physiology and metabolism of pigs have a relatively high resemblance to humans, and the present study aimed to characterize choline …
Choline-deficient-diet Decreases Fibroblasts in the Circulating Tumor Cell (CTC) Microenvironment.
Matsuura K, Suetsugu A, Satake T, Nakamura M, Kunisada T, Shimizu M, Hoffman RM. Matsuura K, et al. Anticancer Res. 2019 Aug;39(8):4061-4064. doi: 10.21873/anticanres.13562. Anticancer Res. 2019. PMID: 31366488
In the present study, we used our malignant lymphoma metastatic mouse model to compare the effect of a choline-deficient-diet (CDD) and the control diet (CD) on fibroblasts in CTCs. MATERIALS AND METHODS: We compared the number and morphology of CTCs i …
In the present study, we used our malignant lymphoma metastatic mouse model to compare the effect of a choline-deficient-di …
Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment.
Nakamura M, Suetsugu A, Hasegawa K, Matsumoto T, Aoki H, Kunisada T, Shimizu M, Saji S, Moriwaki H, Hoffman RM. Nakamura M, et al. Anticancer Res. 2017 Jul;37(7):3429-3434. doi: 10.21873/anticanres.11710. Anticancer Res. 2017. PMID: 28668831
In the present report, we investigated the potential and microenvironment of the fatty liver induced by a choline-deficient diet as a metastatic site in this mouse lymphoma model. MATERIALS AND METHODS: C57BL/6-GFP transgenic mice were fed with a choline …
In the present report, we investigated the potential and microenvironment of the fatty liver induced by a choline-deficient …
A methionine-choline-deficient diet induces nonalcoholic steatohepatitis and alters the lipidome, metabolome, and gut microbiome profile in the C57BL/6J mouse.
Gautam J, Aggarwal H, Kumari D, Gupta SK, Kumar Y, Dikshit M. Gautam J, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Dec;1869(8):159545. doi: 10.1016/j.bbalip.2024.159545. Epub 2024 Jul 31. Biochim Biophys Acta Mol Cell Biol Lipids. 2024. PMID: 39089643
The methionine-choline-deficient (MCD) diet-induced non-alcoholic steatohepatitis (NASH) in mice is a well-established model. ...Male C57BL/6J mice were fed a standard chow diet, a methionine-choline-sufficient (MCS) diet, or an MCD di …
The methionine-choline-deficient (MCD) diet-induced non-alcoholic steatohepatitis (NASH) in mice is a well-established …
Time-Restricted Feeding Ameliorates Methionine-Choline Deficient Diet-Induced Steatohepatitis in Mice.
Jung IR, Ahima RS, Kim SF. Jung IR, et al. Int J Mol Sci. 2024 Jan 23;25(3):1390. doi: 10.3390/ijms25031390. Int J Mol Sci. 2024. PMID: 38338668 Free PMC article.
Therefore, we investigated whether there is a causal link between TRF and IPMK in a mouse model of NASH, i.e., methionine- and choline-deficient diet (MCDD)-induced steatohepatitis. Here, we show that TRF alleviated markers of NASH, i.e., reduced hepatic stea …
Therefore, we investigated whether there is a causal link between TRF and IPMK in a mouse model of NASH, i.e., methionine- and choline …
Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
Wu S, Wu Y, Lin L, Ruan C, Li F, Chen R, Du H, Zhang X, Luo X. Wu S, et al. Sci Rep. 2023 Feb 23;13(1):3194. doi: 10.1038/s41598-023-30001-7. Sci Rep. 2023. PMID: 36823220 Free PMC article.
OPG knockout mice and wild-type control mice fed a methionine choline-deficient diet (MCD) for 4 weeks resulted in an animal model of NASH. Measurement of triglycerides (TG) in serum and liver to assess steatosis. ...Transcriptome sequencing analysis showed t …
OPG knockout mice and wild-type control mice fed a methionine choline-deficient diet (MCD) for 4 weeks resulted in an a …
3,581 results