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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1967 5
1968 3
1969 6
1970 16
1971 45
1972 67
1973 60
1974 117
1975 153
1976 165
1977 101
1978 150
1979 124
1980 134
1981 111
1982 138
1983 119
1984 142
1985 151
1986 172
1987 146
1988 143
1989 136
1990 162
1991 180
1992 210
1993 230
1994 249
1995 320
1996 357
1997 411
1998 506
1999 548
2000 689
2001 828
2002 992
2003 1215
2004 1497
2005 1638
2006 1866
2007 2024
2008 2186
2009 2358
2010 2538
2011 2854
2012 2859
2013 3003
2014 2936
2015 2877
2016 2771
2017 2659
2018 2524
2019 2705
2020 2693
2021 2838
2022 2473
2023 2284
2024 2469
2025 2830
2026 1743

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Search Results

60,207 results

Results by year

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Page 1
Regulation of chromatin architecture by transcription factor binding.
Portillo-Ledesma S, Chung S, Hoffman J, Schlick T. Portillo-Ledesma S, et al. Elife. 2024 Jan 19;12:RP91320. doi: 10.7554/eLife.91320. Elife. 2024. PMID: 38241351 Free PMC article.
We introduce an implicit modeling protocol for Myc:Max binding to mesoscale chromatin fibers at nucleosome resolution to determine TF effect on chromatin architecture and shed light into its mechanism of gene regulation. ...Third, we study the mechanism of ge …
We introduce an implicit modeling protocol for Myc:Max binding to mesoscale chromatin fibers at nucleosome resolution to deter …
Unorthodox PCNA Binding by Chromatin Assembly Factor 1.
Gopinathan Nair A, Rabas N, Lejon S, Homiski C, Osborne MJ, Cyr N, Sverzhinsky A, Melendy T, Pascal JM, Laue ED, Borden KLB, Omichinski JG, Verreault A. Gopinathan Nair A, et al. Int J Mol Sci. 2022 Sep 21;23(19):11099. doi: 10.3390/ijms231911099. Int J Mol Sci. 2022. PMID: 36232396 Free PMC article.
The eukaryotic DNA replication fork is a hub of enzymes that continuously act to synthesize DNA, propagate DNA methylation and other epigenetic marks, perform quality control, repair nascent DNA, and package this DNA into chromatin. Many of the enzymes involved in these sp …
The eukaryotic DNA replication fork is a hub of enzymes that continuously act to synthesize DNA, propagate DNA methylation and other epigene …
Myeloperoxidase transforms chromatin into neutrophil extracellular traps.
Burn GL, Raisch T, Tacke S, Winkler M, Prumbaum D, Thee S, Gimber N, Raunser S, Zychlinsky A. Burn GL, et al. Nature. 2025 Nov;647(8090):747-756. doi: 10.1038/s41586-025-09523-9. Epub 2025 Sep 17. Nature. 2025. PMID: 40963017 Free PMC article.
Our data demonstrate that the binding of MPO to chromatin is governed by specific molecular interactions that transform chromatin into a non-replicative, non-encoding state that offers new biological functions in a cell-free manner. We propose that MPO is, to …
Our data demonstrate that the binding of MPO to chromatin is governed by specific molecular interactions that transform chr …
Conserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1.
Tauber M, Fischle W. Tauber M, et al. Nucleus. 2015;6(2):123-32. doi: 10.1080/19491034.2015.1026022. Nucleus. 2015. PMID: 25891992 Free PMC article. Review.
Separate chromatin-binding modules of UHRF1 have been studied on a functional and structural level. ...We propose that these are essential in setting up defined structural states of the protein where different domains or combinations thereof are available for bin …
Separate chromatin-binding modules of UHRF1 have been studied on a functional and structural level. ...We propose that these a …
CTCF: the protein, the binding partners, the binding sites and their chromatin loops.
Holwerda SJ, de Laat W. Holwerda SJ, et al. Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120369. doi: 10.1098/rstb.2012.0369. Print 2013. Philos Trans R Soc Lond B Biol Sci. 2013. PMID: 23650640 Free PMC article. Review.
It can act as a transcriptional activator, repressor and insulator, and it can pause transcription. CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies. ...It appears to be determined by the associated transcription fac …
It can act as a transcriptional activator, repressor and insulator, and it can pause transcription. CTCF binds at chromatin do …
Condensin II activation by M18BP1.
Borsellini A, Conti D, Cutts EE, Harris RJ, Walstein K, Graziadei A, Cecatiello V, Aarts TF, Xie R, Mazouzi A, Sen S, Hoencamp C, Pleuger R, Ghetti S, Oberste-Lehn L, Pan D, Bange T, Haarhuis JHI, Perrakis A, Brummelkamp TR, Rowland BD, Musacchio A, Vannini A. Borsellini A, et al. Mol Cell. 2025 Jul 17;85(14):2688-2700.e11. doi: 10.1016/j.molcel.2025.06.014. Epub 2025 Jul 3. Mol Cell. 2025. PMID: 40614722 Free article.
While condensin II is known to initiate this process in early mitosis, what triggers its activation and loading onto chromatin at this juncture remains unclear. Through genetic and proteomic approaches, we identify MIS18-binding protein 1 (M18BP1), a protein require …
While condensin II is known to initiate this process in early mitosis, what triggers its activation and loading onto chromatin at thi …
EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming.
Zeng Y, Kong F, Xu Z, Lu X, Li Q, Liu B, Liu S, Dong L, Liu L, Wang W, Zhu B, Xie W. Zeng Y, et al. Cell Stem Cell. 2025 Nov 6;32(11):1741-1757.e5. doi: 10.1016/j.stem.2025.09.009. Epub 2025 Oct 20. Cell Stem Cell. 2025. PMID: 41118764
Here, we show that PRC2, which catalyzes H3K27me3, binds both classic Polycomb targets and noncanonical H3K27me3 domains in growing oocytes but dissociates from chromatin in fully grown oocytes. After fertilization, PRC2 rebinds noncanonical H3K27me3 domains before …
Here, we show that PRC2, which catalyzes H3K27me3, binds both classic Polycomb targets and noncanonical H3K27me3 domains in growing o …
Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns.
Noble TD, Sansam CG, Wittig KA, Majchrzycka B, Sansam CL. Noble TD, et al. Genome Biol. 2025 Jul 7;26(1):194. doi: 10.1186/s13059-025-03665-9. Genome Biol. 2025. PMID: 40624716 Free PMC article.
MTBP binds to early-mid replicating regions in an early S population. Our data suggest MTBP is dependent on TRESLIN for proper association with chromatin during G1 but not S phase. We show that TRESLIN and MTBP binding during G1 does not require origins licen …
MTBP binds to early-mid replicating regions in an early S population. Our data suggest MTBP is dependent on TRESLIN for proper associ …
PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type.
Lupey-Green LN, Caruso LB, Madzo J, Martin KA, Tan Y, Hulse M, Tempera I. Lupey-Green LN, et al. J Virol. 2018 Aug 29;92(18):e00755-18. doi: 10.1128/JVI.00755-18. Print 2018 Sep 15. J Virol. 2018. PMID: 29976663 Free PMC article.
The EBV genome persists in infected host cells as a chromatinized episome and is subject to chromatin-mediated regulation. Binding of the host insulator protein CTCF to the EBV genome has an established role in maintaining viral latency type. ...PARylation of …
The EBV genome persists in infected host cells as a chromatinized episome and is subject to chromatin-mediated regulation. …
Nucleosomes specify co-factor access to p53.
Chakraborty D, Sandate CR, Isbel L, Kempf G, Weiss J, Cavadini S, Kater L, Seebacher J, Kozicka Z, Stoos L, Grand RS, Schübeler D, Michael AK, Thomä NH. Chakraborty D, et al. Mol Cell. 2025 Aug 7;85(15):2919-2936.e12. doi: 10.1016/j.molcel.2025.06.027. Epub 2025 Jul 25. Mol Cell. 2025. PMID: 40713947 Free article.
Pioneer transcription factors (TFs) engage chromatinized DNA motifs. However, it is unclear how the resultant TF-nucleosome complexes are decoded by co-factors. In humans, the TF p53 regulates cell-cycle progression, apoptosis, and the DNA damage response, with a large fra …
Pioneer transcription factors (TFs) engage chromatinized DNA motifs. However, it is unclear how the resultant TF-nucleosome complexes …
60,207 results
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