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Page 1
Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease.
Rahman I, MacNee W. Rahman I, et al. Am J Physiol. 1999 Dec;277(6):L1067-88. doi: 10.1152/ajplung.1999.277.6.L1067. Am J Physiol. 1999. PMID: 10600876 Review.
Alterations in alveolar and lung GSH metabolism are widely recognized as a central feature of many inflammatory lung diseases including chronic obstructive pulmonary disease (COPD). Cigarette smoking, the major factor in the pathogenesis of COPD, increases GSH in th …
Alterations in alveolar and lung GSH metabolism are widely recognized as a central feature of many inflammatory lung diseases including chro …
Cigarette smoke irreversibly modifies glutathione in airway epithelial cells.
van der Toorn M, Smit-de Vries MP, Slebos DJ, de Bruin HG, Abello N, van Oosterhout AJ, Bischoff R, Kauffman HF. van der Toorn M, et al. Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1156-62. doi: 10.1152/ajplung.00081.2007. Epub 2007 Aug 24. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 17720877 Free article.
Cigarette smoke (CS) is known to deplete total glutathione (GSH + GSSG) in the airways. ...Our data show that CS does not oxidize GSH to GSSG but, rather, reacts to nonreducible glutathione-aldehyde derivatives, thereby depletin …
Cigarette smoke (CS) is known to deplete total glutathione (GSH + GSSG) in the airways. ...Our data show …
Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells.
Kode A, Yang SR, Rahman I. Kode A, et al. Respir Res. 2006 Oct 24;7(1):132. doi: 10.1186/1465-9921-7-132. Respir Res. 2006. PMID: 17062156 Free PMC article.
BACKGROUND: Cigarette smoke mediated oxidative stress and inflammatory events in the airway and alveolar epithelium are important processes in the pathogenesis of smoking related pulmonary diseases. Previously, individual cell lines were used to …
BACKGROUND: Cigarette smoke mediated oxidative stress and inflammatory events in the airway and alveolar epithel …
Cigarette smoke-induced differential regulation of glutathione metabolism in bronchial epithelial cells is balanced by an antioxidant tetrapeptide UPF1.
Altraja S, Mahlapuu R, Soomets U, Altraja A. Altraja S, et al. Exp Toxicol Pathol. 2013 Sep;65(6):711-7. doi: 10.1016/j.etp.2012.09.005. Epub 2012 Oct 11. Exp Toxicol Pathol. 2013. PMID: 23062287
Airway epithelium is a principal target for inhaled oxidants like cigarette smoke, which induce epithelial injury and thereby provoke pathogenesis of chronic airway diseases. ...We showed a transient depletion of intracellular GSH in huma …
Airway epithelium is a principal target for inhaled oxidants like cigarette smoke, which induce epithelial injur …
Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants.
Benedikter BJ, Volgers C, van Eijck PH, Wouters EFM, Savelkoul PHM, Reynaert NL, Haenen GRMM, Rohde GGU, Weseler AR, Stassen FRM. Benedikter BJ, et al. Free Radic Biol Med. 2017 Jul;108:334-344. doi: 10.1016/j.freeradbiomed.2017.03.026. Epub 2017 Mar 28. Free Radic Biol Med. 2017. PMID: 28359953
INTRODUCTION: Airway epithelial cells have been described to release extracellular vesicles (EVs) with pathological properties when exposed to cigarette smoke extract (CSE). As CSE causes oxidative stress, we investigated whether its oxidative c …
INTRODUCTION: Airway epithelial cells have been described to release extracellular vesicles (EVs) with pathological properties when e …
Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.
Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S. Blake DJ, et al. Am J Respir Cell Mol Biol. 2010 May;42(5):524-36. doi: 10.1165/rcmb.2009-0054OC. Epub 2009 Jun 11. Am J Respir Cell Mol Biol. 2010. PMID: 19520915 Free PMC article.
Exposure to cigarette smoke (CS) is the primary factor associated with the development of chronic obstructive pulmonary disease (COPD). CS increases the level of oxidants in the lungs, resulting in a depletion of antioxidants, which promotes oxidati …
Exposure to cigarette smoke (CS) is the primary factor associated with the development of chronic obstructive pulmonary diseas …
Third-Hand Smoke Exacerbates H(2)O(2)-Driven Airway Responses in A549 Cells.
Reis R, Kolci K, Özhan Y, Çoşkun GP, Sipahi H. Reis R, et al. Turk J Pharm Sci. 2024 Nov 21;21(5):376-389. doi: 10.4274/tjps.galenos.2024.36153. Turk J Pharm Sci. 2024. PMID: 39569661 Free PMC article.
OBJECTIVES: Third-hand smoke (THS) is residual smoke after extinguishing a cigarette and adhering to surfaces. ...CONCLUSION: The induction of oxidative stress may be an important event in THS-induced airway toxicity that may contribute to the p …
OBJECTIVES: Third-hand smoke (THS) is residual smoke after extinguishing a cigarette and adhering to surfaces. ...CONCL …
Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells.
Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I. Kode A, et al. Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L478-88. doi: 10.1152/ajplung.00361.2007. Epub 2007 Dec 27. Am J Physiol Lung Cell Mol Physiol. 2008. PMID: 18162601 Free article.
Nuclear erythroid-related factor 2 (Nrf2), a redox-sensitive transcription factor, is involved in transcriptional regulation of many antioxidant genes, including glutamate-cysteine ligase (GCL). Cigarette smoke (CS) is known to cause oxidative stress and d …
Nuclear erythroid-related factor 2 (Nrf2), a redox-sensitive transcription factor, is involved in transcriptional regulation of many antioxi …
The Relationship Between Airway Antioxidant Levels, Alcohol Use Disorders, and Cigarette Smoking.
Burnham EL, McNally A, Gaydos J, Brown LA. Burnham EL, et al. Alcohol Clin Exp Res. 2016 Oct;40(10):2147-2160. doi: 10.1111/acer.13201. Epub 2016 Sep 14. Alcohol Clin Exp Res. 2016. PMID: 27627733 Free PMC article.
BACKGROUND: Alcohol use disorders (AUDs) and cigarette smoking are associated with pulmonary oxidative stress, likely related to antioxidant depletion. ...CONCLUSIONS: A small volume BAL procedure may be suitable to assess intrapulmonary oxidative …
BACKGROUND: Alcohol use disorders (AUDs) and cigarette smoking are associated with pulmonary oxidative stress, likely r …
Current perspectives of oxidative stress and its measurement in chronic obstructive pulmonary disease.
Lin JL, Thomas PS. Lin JL, et al. COPD. 2010 Aug;7(4):291-306. doi: 10.3109/15412555.2010.496818. COPD. 2010. PMID: 20673039 Free article. Review.
Cigarette smoking, the principal aetiology of chronic obstructive pulmonary disease (COPD) in the developed countries, delivers and generates oxidative stress within the lungs. ...The lung has a large reserve of antioxidant agents such as glutathione a …
Cigarette smoking, the principal aetiology of chronic obstructive pulmonary disease (COPD) in the developed countries, deliver …
15 results