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1,913 results

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Page 1
Cilium assembly and disassembly.
Sánchez I, Dynlacht BD. Sánchez I, et al. Nat Cell Biol. 2016 Jun 28;18(7):711-7. doi: 10.1038/ncb3370. Nat Cell Biol. 2016. PMID: 27350441 Free PMC article. Review.
The primary cilium is an antenna-like, immotile organelle present on most types of mammalian cells, which interprets extracellular signals that regulate growth and development. ...Recent studies have begun to clarify the key mechanisms that link cilium assembly …
The primary cilium is an antenna-like, immotile organelle present on most types of mammalian cells, which interprets extracellular si …
Cilium structure, assembly, and disassembly regulated by the cytoskeleton.
Mirvis M, Stearns T, James Nelson W. Mirvis M, et al. Biochem J. 2018 Jul 31;475(14):2329-2353. doi: 10.1042/BCJ20170453. Biochem J. 2018. PMID: 30064990 Free PMC article. Review.
The cilium undergoes cycles of assembly and disassembly that are controlled by complex inter-relationships with the cytoskeleton. ...Although actin and septin cytoskeletons are not major components of the axoneme, they also regulate cilium organization and …
The cilium undergoes cycles of assembly and disassembly that are controlled by complex inter-relationships with the cytoskelet …
Functional aspects of primary cilium in signaling, assembly and microenvironment in cancer.
Wang B, Liang Z, Liu P. Wang B, et al. J Cell Physiol. 2021 May;236(5):3207-3219. doi: 10.1002/jcp.30117. Epub 2020 Oct 26. J Cell Physiol. 2021. PMID: 33107052 Free PMC article. Review.
Evidence is accumulating that ciliary defects lead to ciliopathies and ciliary deregulation also play crucial roles in cancer formation and progression. Interestingly, restoring the cilia can suppress proliferation in some cancer cell. However, t he role of primary cili …
Evidence is accumulating that ciliary defects lead to ciliopathies and ciliary deregulation also play crucial roles in cancer formation and …
The regulation of cilium assembly and disassembly in development and disease.
Wang L, Dynlacht BD. Wang L, et al. Development. 2018 Sep 17;145(18):dev151407. doi: 10.1242/dev.151407. Development. 2018. PMID: 30224385 Free PMC article. Review.
The primary cilium is an antenna-like organelle assembled on most types of quiescent and differentiated mammalian cells. ...Here, we review these exciting new findings, discussing the molecular factors involved in cilium formation and removal, the intrinsic and extr …
The primary cilium is an antenna-like organelle assembled on most types of quiescent and differentiated mammalian cells. ...Here, we …
Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.
Wang L, Paudyal SC, Kang Y, Owa M, Liang FX, Spektor A, Knaut H, Sánchez I, Dynlacht BD. Wang L, et al. Cell Res. 2022 Feb;32(2):190-209. doi: 10.1038/s41422-021-00584-9. Epub 2021 Nov 15. Cell Res. 2022. PMID: 34782749 Free PMC article.
However, the role of microtubule (MT) post-translational modifications in nuclear shape regulation and cilium disassembly has not been explored. Here we identified a novel regulator of the tubulin polyglutamylase complex (TPGC), C11ORF49/CSTPP1, that regulates cytoskeletal …
However, the role of microtubule (MT) post-translational modifications in nuclear shape regulation and cilium disassembly has not bee …
The perennial organelle: assembly and disassembly of the primary cilium.
Seeley ES, Nachury MV. Seeley ES, et al. J Cell Sci. 2010 Feb 15;123(Pt 4):511-8. doi: 10.1242/jcs.061093. J Cell Sci. 2010. PMID: 20144999 Free PMC article. Review.
Although there is clear evidence demonstrating that these organelles are assembled and disassembled dynamically as cells progress through the cell cycle, the mechanisms by which the cell cycle controls the assembly and disassembly of the primary cilium remain poorly …
Although there is clear evidence demonstrating that these organelles are assembled and disassembled dynamically as cells progress through th …
CEP76 impairment at the centrosome-cilium interface contributes to a spectrum of ciliopathies.
Khan K, Tavares E, Bishara K, Ozanturk A, Qebibo L, Frangakis S, Calame DG, Meunier I, Bocquet B, Ploski R, Al Khateeb MA, Marafi D, Mansard L, Damaj L, Lewis RA, Ullah F, Arbogast T, Ogden JP, Harion M, Willems M, Zaki MS, Bartolomaeus T, Roux AF, Lupski JR, Rydzanicz M, Jamra RA, Ramond F, Heon E, Burglen L, Davis EE. Khan K, et al. Sci Adv. 2025 Oct 17;11(42):eadw3717. doi: 10.1126/sciadv.adw3717. Epub 2025 Oct 17. Sci Adv. 2025. PMID: 41105778 Free PMC article.
Proband-derived fibroblasts and CEP76-depleted RPE1 cells display ciliary deficits, including impaired cilium formation and length, disrupted transition zone architecture, and impaired IFT88-mediated anterograde intraflagellar transport. ...Together, these findings expand …
Proband-derived fibroblasts and CEP76-depleted RPE1 cells display ciliary deficits, including impaired cilium formation and length, d …
Movement.
Ferkol T. Ferkol T. Paediatr Respir Rev. 2017 Sep;24:19-20. doi: 10.1016/j.prrv.2017.06.005. Epub 2017 Jun 12. Paediatr Respir Rev. 2017. PMID: 28687245 Review.
Our understanding of the complex genetics and functional phenotypes of primary ciliary dyskinesia has rapidly grown, and over 35 disease-associated genes have been identified, which segregate into genes that encode axonemal motor proteins, regulatory proteins within the cilium …
Our understanding of the complex genetics and functional phenotypes of primary ciliary dyskinesia has rapidly grown, and over 35 disease-ass …
Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner.
Robichaud JH, Zhang Y, Chen C, He K, Huang Y, Zhang X, Sun X, Ma X, Hardiman G, Morrison CG, Dong Z, LeBrasseur NK, Ling K, Hu J. Robichaud JH, et al. Nat Commun. 2024 Sep 12;15(1):7977. doi: 10.1038/s41467-024-52363-w. Nat Commun. 2024. PMID: 39266565 Free PMC article.
Here we discover that an early cellular event occurring in stressed cells is the transient assembly of stress-induced nucleus-to-cilium microtubule arrays (sinc-MTs). The sinc-MTs are distinguished by unusual polyglutamylation and unique polarity, with minus-ends nu …
Here we discover that an early cellular event occurring in stressed cells is the transient assembly of stress-induced nucleus-to-c …
Intraflagellar transport.
Rosenbaum JL, Witman GB. Rosenbaum JL, et al. Nat Rev Mol Cell Biol. 2002 Nov;3(11):813-25. doi: 10.1038/nrm952. Nat Rev Mol Cell Biol. 2002. PMID: 12415299 Review.
Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved organelles that project from the surfaces of many cells. The assembly and maintenance of these nearly ubiquitous structures are dependent on a transport syst …
Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved organelles that project …
1,913 results