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Year Number of Results
1945 393
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1947 410
1948 386
1949 536
1950 634
1951 658
1952 733
1953 618
1954 517
1955 513
1956 485
1957 461
1958 342
1959 394
1960 266
1961 306
1962 251
1963 343
1964 545
1965 356
1966 154
1967 121
1968 109
1969 100
1970 98
1971 60
1972 48
1973 47
1974 50
1975 33
1976 8
1977 42
1978 52
1979 60
1980 79
1981 77
1982 37
1983 27
1984 53
1985 26
1986 28
1987 36
1988 93
1989 92
1990 88
1991 73
1992 88
1993 63
1994 76
1995 69
1996 71
1997 60
1998 68
1999 58
2000 74
2001 96
2002 76
2003 229
2004 244
2005 637
2006 688
2007 784
2008 825
2009 1013
2010 1007
2011 1129
2012 1335
2013 1282
2014 1371
2015 1358
2016 1233
2017 1229
2018 1163
2019 1256
2020 1577
2021 1541
2022 1596
2023 1616
2024 1550
2025 825

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35,041 results

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Page 1
CiR-EIS alleviates metabolic dysfunction-associated steatohepatitis by modulating macrophage polarization involving the miR-548m/IGF1 axis.
Chen X, Wan Z, Wu L, Cai X, Si H, Liu X, Zhao Q, Xu F, Deng H. Chen X, et al. Clin Nutr. 2025 Jul;50:104-116. doi: 10.1016/j.clnu.2025.05.009. Epub 2025 May 14. Clin Nutr. 2025. PMID: 40409233
Retrospective clinical records were analyzed to examine the association between cir-EIS, IGF1, and MASH. RESULTS: CiR-EIS was downregulated in patients with MASH and colocalized with the macrophage marker CD68. ...CiR-EIS regulated macrophage polarization in …
Retrospective clinical records were analyzed to examine the association between cir-EIS, IGF1, and MASH. RESULTS: CiR-EIS was …
Cir-ITCH inhibits gastric cancer migration, invasion and proliferation by regulating the Wnt/beta-catenin pathway.
Peng Y, Wang HH. Peng Y, et al. Sci Rep. 2020 Oct 15;10(1):17443. doi: 10.1038/s41598-020-74452-8. Sci Rep. 2020. PMID: 33060778 Free PMC article.
Circular RNAs (circRNAs) are differentially expressed in various tumours, but the expression and regulatory mechanisms of circular RNA ITCH (cir-ITCH) in gastric cancer remain unclear. For this reason, in the present study, we assessed the expression of cir-ITCH and …
Circular RNAs (circRNAs) are differentially expressed in various tumours, but the expression and regulatory mechanisms of circular RNA ITCH …
lncRNA-CIR regulates cell apoptosis of chondrocytes in osteoarthritis.
Lu Z, Luo M, Huang Y. Lu Z, et al. J Cell Biochem. 2019 May;120(5):7229-7237. doi: 10.1002/jcb.27997. Epub 2018 Nov 2. J Cell Biochem. 2019. PMID: 30390341
RESULTS: lncRNA-CIR is significantly upregulated in OA patients, accompanied by downregulation of miR-130a and upregulation of Bim. Bio-informatics analysis predicted miR-130a as a target of both lncRNA-CIR and Bim. While lncRNA-CIR knockdown significantly in …
RESULTS: lncRNA-CIR is significantly upregulated in OA patients, accompanied by downregulation of miR-130a and upregulation of Bim. B …
LncRNA-CIR promotes articular cartilage degeneration in osteoarthritis by regulating autophagy.
Wang CL, Peng JP, Chen XD. Wang CL, et al. Biochem Biophys Res Commun. 2018 Nov 2;505(3):692-698. doi: 10.1016/j.bbrc.2018.09.163. Epub 2018 Oct 3. Biochem Biophys Res Commun. 2018. PMID: 30292414
The use of si-lncRNA-CIR reversed the trend compared with that in the OA group. The negative effect of lncRNA-CIR was assessed in vivo by establishing a model of surgically induced OA. ...Overall, lncRNA-CIR played a negative role in the OA process by activat …
The use of si-lncRNA-CIR reversed the trend compared with that in the OA group. The negative effect of lncRNA-CIR was assessed …
Long non-coding RNA CIR inhibits chondrogenic differentiation of mesenchymal stem cells by epigenetically suppressing ATOH8 via methyltransferase EZH2.
Liu F, Song DY, Huang J, Yang HQ, You D, Ni JD. Liu F, et al. Mol Med. 2021 Feb 5;27(1):12. doi: 10.1186/s10020-021-00272-9. Mol Med. 2021. PMID: 33546582 Free PMC article.
Although the incidence of OA is increasing globally, the treatment of OA is very limited. LncRNA CIR has been implicated in OA through unclear mechanisms. Here, we investigated the role of lncRNA CIR in chondrogenic differentiation. ...Inhibition of ATOH8 reversed t …
Although the incidence of OA is increasing globally, the treatment of OA is very limited. LncRNA CIR has been implicated in OA throug …
Puerarin mitigates cerebral ischemia/reperfusion (CIR)-induced ferroptosis by suppressing Ser15 phosphorylation-mediated p53 activation.
Xu G, Zhang J, Shao C, Wu H, Shen J, Wang Y, Li Y, Li C, Yu L, Zhou H, Wan H, Yang J. Xu G, et al. Free Radic Biol Med. 2025 Jun 10;237:383-396. doi: 10.1016/j.freeradbiomed.2025.06.013. Online ahead of print. Free Radic Biol Med. 2025. PMID: 40505745
Puerarin, an antioxidant compound extracted from the Pueraria lobata root, has been widely used as an effective therapeutic agent for CIR injury. However, the underlying mechanisms remain unclear. Here, we comprehensively investigated the protective effects of puerarin aga …
Puerarin, an antioxidant compound extracted from the Pueraria lobata root, has been widely used as an effective therapeutic agent for CIR …
Circular RNA cir-ITCH Is a Potential Therapeutic Target for the Treatment of Castration-Resistant Prostate Cancer.
Li S, Yu C, Zhang Y, Liu J, Jia Y, Sun F, Zhang P, Li J, Guo L, Xiao H, Gao F, Deng X, Cai Z, Cai J. Li S, et al. Biomed Res Int. 2020 Aug 20;2020:7586521. doi: 10.1155/2020/7586521. eCollection 2020. Biomed Res Int. 2020. PMID: 32904490 Free PMC article.
cir-ITCH, a well-known tumor-suppressive circular RNA, plays a critical role in different cancers. ...The results showed that cir-ITCH overexpression significantly inhibits the proliferation, migration, and invasion of human PCa cells and that reciprocal inhibition …
cir-ITCH, a well-known tumor-suppressive circular RNA, plays a critical role in different cancers. ...The results showed that cir …
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD. Hsieh JJ, et al. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):23-8. doi: 10.1073/pnas.96.1.23. Proc Natl Acad Sci U S A. 1999. PMID: 9874765 Free PMC article.
We have examined the mechanism of CBF1-mediated repression and show that CBF1 binds to a unique corepressor, CBF1 interacting corepressor (CIR). A CIR homolog is encoded by Caenorhabditis elegans, indicating that CIR is evolutionarily conserved. Two CBF1 muta …
We have examined the mechanism of CBF1-mediated repression and show that CBF1 binds to a unique corepressor, CBF1 interacting corepressor ( …
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing.
Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM. Maita H, et al. Exp Cell Res. 2005 Feb 15;303(2):375-87. doi: 10.1016/j.yexcr.2004.10.012. Epub 2004 Nov 18. Exp Cell Res. 2005. PMID: 15652350
CIR was found to be colocalized with SC35 and PAP-1 in nuclear speckles. Then the effect of CIR on splicing was investigated using the E1a minigene as a reporter in HeLa cells. ...These results indicate that CIR is a member of the family of SR-related protein …
CIR was found to be colocalized with SC35 and PAP-1 in nuclear speckles. Then the effect of CIR on splicing was investigated u …
cir, a gene conferring resistance to colicin I maps between mgl and fpk on the Escherichia coli chromosome.
Boos W, Bantlow C, Benner D, Roller E. Boos W, et al. Mol Gen Genet. 1983;191(3):401-6. doi: 10.1007/BF00425754. Mol Gen Genet. 1983. PMID: 6314091
With the help of the tetracycline resistance transposon Tn10 in and around the mgl genes the gene cir was mapped. cir is 80% cotransducible with mgl by P1 transduction. The sequence of the surrounding markers in clockwise order was established as: cdd fpk cir …
With the help of the tetracycline resistance transposon Tn10 in and around the mgl genes the gene cir was mapped. cir is 80% c …
35,041 results
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