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11 results

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Page 1
Estrogens and autoimmune diseases.
Cutolo M, Capellino S, Sulli A, Serioli B, Secchi ME, Villaggio B, Straub RH. Cutolo M, et al. Ann N Y Acad Sci. 2006 Nov;1089:538-47. doi: 10.1196/annals.1386.043. Ann N Y Acad Sci. 2006. PMID: 17261796 Review.
Abnormal regulation of aromatase activity (i.e., increased activity) by inflammatory cytokine production (i.e., TNF-alpha, IL-1, and IL-6) may partially explain the abnormalities of peripheral estrogen synthesis in RA (i.e., increased availability of 1 …
Abnormal regulation of aromatase activity (i.e., increased activity) by inflammatory cytokine production (i.e., TNF-alpha, IL- …
Circadian use of glucocorticoids in rheumatoid arthritis.
Cutolo M, Sulli A, Pincus T. Cutolo M, et al. Neuroimmunomodulation. 2015;22(1-2):33-9. doi: 10.1159/000362733. Epub 2014 Sep 12. Neuroimmunomodulation. 2015. PMID: 25227591 Review.
A clear temporal relationship exists in rheumatoid arthritis (RA) patients between increased nocturnal levels of pro-inflammatory cytokines, such as TNF-alpha and interleukin (IL)-6, pro-inflammatory hormones (i.e. melatonin, prolactin) and insufficien …
A clear temporal relationship exists in rheumatoid arthritis (RA) patients between increased nocturnal levels of pro-inflammatory cytokin …
Circadian timekeeping is disturbed in rheumatoid arthritis at molecular level.
Kouri VP, Olkkonen J, Kaivosoja E, Ainola M, Juhila J, Hovatta I, Konttinen YT, Mandelin J. Kouri VP, et al. PLoS One. 2013;8(1):e54049. doi: 10.1371/journal.pone.0054049. Epub 2013 Jan 15. PLoS One. 2013. PMID: 23335987 Free PMC article.
The effect of pro-inflammatory stimulus on clock gene expression in synovial fibroblasts was studied using IL-6 and TNF-alpha. RESULTS: Gene expression analysis disclosed disconcerted circadian timekeeping and immunohistochemistry revealed strong cytop …
The effect of pro-inflammatory stimulus on clock gene expression in synovial fibroblasts was studied using IL-6 and TNF …
The influence of regulatory T cells and diurnal hormone rhythms on T helper cell activity.
Bollinger T, Bollinger A, Naujoks J, Lange T, Solbach W. Bollinger T, et al. Immunology. 2010 Dec;131(4):488-500. doi: 10.1111/j.1365-2567.2010.03320.x. Immunology. 2010. PMID: 20646075 Free PMC article.
Additionally, we observed that nTreg suppressed the secretion of IFN-gamma, IL-2 and TNF-alpha, but not the secretion of IL-4, IL-6, IL-10 and IL-17A. However, the abrogation of IL-2 release was reversed upon inhibiting CD25 on nTreg. Highly purified n …
Additionally, we observed that nTreg suppressed the secretion of IFN-gamma, IL-2 and TNF-alpha, but not the secretion of IL-4, IL …
Role of methotrexate chronotherapy in collagen-induced rheumatoid arthritis in rats.
Wang X, Yan X, Wang F, Ge F, Li Z. Wang X, et al. Z Rheumatol. 2018 Apr;77(3):249-255. doi: 10.1007/s00393-016-0236-6. Z Rheumatol. 2018. PMID: 27900440 Free PMC article.
Arthritis score, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and C reactive protein (CRP) levels in the serum were measured by enzyme-linked immunosorbent assay (ELISA). ...The therapeutic index of rheumatoid arthritis (RA) may be improved with MTX …
Arthritis score, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and C reactive protein (CRP) levels in the seru …
Alterations of the hypothalamic-pituitary-adrenal axis in systemic immune diseases - a role for misguided energy regulation.
Straub RH, Buttgereit F, Cutolo M. Straub RH, et al. Clin Exp Rheumatol. 2011 Sep-Oct;29(5 Suppl 68):S23-31. Epub 2011 Oct 21. Clin Exp Rheumatol. 2011. PMID: 22018180 Review.
The investigation of the hypothalamicpituitary-adrenal (HPA) axis in chronic inflammation has demonstrated: 1) an anti-inflammatory influence of the HPA axis; 2) low serum levels of adrenal androgen; 3) equivocal results with respect to levels of adrenocorticotropic hormone and c …
The investigation of the hypothalamicpituitary-adrenal (HPA) axis in chronic inflammation has demonstrated: 1) an anti-inflammatory influenc …
Circadian variations in clinical symptoms and concentrations of inflammatory cytokines, melatonin, and cortisol in polymyalgia rheumatica before and during prednisolone treatment: a controlled, observational, clinical experimental study.
Galbo H, Kall L. Galbo H, et al. Arthritis Res Ther. 2016 Jul 26;18(1):174. doi: 10.1186/s13075-016-1072-4. Arthritis Res Ther. 2016. PMID: 27455959 Free PMC article.

RESULTS: In untreated patients, pain and stiffness peaked in the early morning, showing a plateau between 04:00 and 08:00, and then declined to a nadir at 16:00 (2P < 0.05). Plasma concentrations of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF

…
RESULTS: In untreated patients, pain and stiffness peaked in the early morning, showing a plateau between 04:00 and 08:00, and then declined …
Correlation of IL-6 with the classical humoral disease activity parameters ESR and CRP and with serum cortisol, reflecting the activity of the HPA axis in active rheumatoid arthritis.
Boss B, Neeck G. Boss B, et al. Z Rheumatol. 2000;59 Suppl 2:II/62-4. doi: 10.1007/s003930070020. Z Rheumatol. 2000. PMID: 11155806
Rheumatoid arthritis (RA) is a systemic inflammatory disease with elevated levels of proinflammatory cytokines in peripheral blood, especially IL-6, but also IL-1 alpha and TNF alpha, for example, in different concentrations, depending on disease activ …
Rheumatoid arthritis (RA) is a systemic inflammatory disease with elevated levels of proinflammatory cytokines in peripheral blood, e …
Expressions of circadian clock genes represent disease activities of RA patients treated with biological DMARDs.
Kaneshiro K, Yoshida K, Morii K, Oketani Y, Uchida K, Yaekura A, Okumura I, Hashimoto T, Kawasaki Y, Shibanuma N, Sakai Y, Hashiramoto A. Kaneshiro K, et al. Mod Rheumatol. 2020 Mar;30(2):293-300. doi: 10.1080/14397595.2019.1602242. Epub 2019 May 2. Mod Rheumatol. 2020. PMID: 30942638 Free article.
Objectives: Rheumatoid Arthritis (RA) is the autoimmune disease representing the circadian variations of symptoms such as morning stiffness of joints or increased production of cytokines around midnight. Clock genes have been reported to affect on the pathogenesis o …
Objectives: Rheumatoid Arthritis (RA) is the autoimmune disease representing the circadian variations of symptoms such as morning sti …
Electroacupuncture alleviates acute gouty arthritis by inhibiting NLRP3 inflammasome activation via modulation of the circadian-inflammation axis.
Li J, Xiao B, Liu S, Zhong W, Wu X, Xie L, Huang Y, Chen Z, Xu Z, Lin W, Li M, Zhang K, Cai L. Li J, et al. Int Immunopharmacol. 2026 Jun 15;179:116650. doi: 10.1016/j.intimp.2026.116650. Epub 2026 Apr 11. Int Immunopharmacol. 2026. PMID: 41967209 Free article.
In MSU-induced GA rats, EA significantly alleviated joint swelling, improved gait, reduced serum TNF-alpha, IL-6 and IL-1beta, and suppressed synovial inflammatory infiltration. Mechanistically, EA downregulated NLRP3, caspase-1 and IL-1beta in joint tissue. …
In MSU-induced GA rats, EA significantly alleviated joint swelling, improved gait, reduced serum TNF-alpha, IL-6 and IL …
11 results