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Mechanisms underlying the anti-aging activity of bergamot (Citrus bergamia) extract in human red blood cells.
Remigante A, Spinelli S, Straface E, Gambardella L, Russo M, Cafeo G, Caruso D, Falliti G, Dugo P, Dossena S, Marino A, Morabito R. Remigante A, et al. Front Physiol. 2023 Jun 30;14:1225552. doi: 10.3389/fphys.2023.1225552. eCollection 2023. Front Physiol. 2023. PMID: 37457030 Free PMC article.
Aim: This investigation aims to verify the potential protective role of bergamot (Citrus bergamia, Femminello cultivar) peel and juice extract in a model of aging represented by human red blood cells (RBCs) exposed to D-Galactose (DGal). ...In addition, the a …
Aim: This investigation aims to verify the potential protective role of bergamot (Citrus bergamia, Femminello cultivar) peel a …
Chemical, Nutritional and Biological Evaluation of a Sustainable and Scalable Complex of Phytochemicals from Bergamot By-Products.
Della Vedova L, Gado F, Vieira TA, Grandini NA, Palácio TLN, Siqueira JS, Carini M, Bombardelli E, Correa CR, Aldini G, Baron G. Della Vedova L, et al. Molecules. 2023 Mar 26;28(7):2964. doi: 10.3390/molecules28072964. Molecules. 2023. PMID: 37049725 Free PMC article.
The present paper reports a sustainable raw material obtained from the by-products derived from the industrial production of bergamot (Citrus Bergamia Risso & Poiteau) essential oils. The procedure to obtain the raw material is designed to maintain as much of …
The present paper reports a sustainable raw material obtained from the by-products derived from the industrial production of bergamot …
Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
Riillo C, Parafati M, Crupi F, Fotschki B, Ragusa M, Di Vito A, Mignogna C, Mollace V, Janda E. Riillo C, et al. Nutrients. 2025 Nov 25;17(23):3684. doi: 10.3390/nu17233684. Nutrients. 2025. PMID: 41373976 Free PMC article.
This was associated with a significant increase in blood glucose, triglycerides, and total cholesterol levels, and a decrease in caecal short-chain fatty acids (SCFAs). Importantly, mice co-treated with BPF showed strongly reduced steatosis compared to CAF mice, low …
This was associated with a significant increase in blood glucose, triglycerides, and total cholesterol levels, and a decrease …
Metabolic outcomes of bergamot polyphenolic fraction administration in patients treated with second-generation antipsychotics: a pilot study.
Bruno A, Pandolfo G, Crucitti M, Maisano A, Zoccali RA, Muscatello MRA. Bruno A, et al. J Nutr Biochem. 2017 Feb;40:32-35. doi: 10.1016/j.jnutbio.2016.10.008. Epub 2016 Oct 22. J Nutr Biochem. 2017. PMID: 27846426 Clinical Trial.
Second-generation antipsychotics (SGAs) are notoriously associated with a marked increase in body weight and with a wide range of metabolic adverse effects, and their chronic use is related with an increased risk for the development of metabolic syndrome (MS). ... …
Second-generation antipsychotics (SGAs) are notoriously associated with a marked increase in body weight and with a wide range of metabol …
Powder bergamot juice attenuates skeletal muscle complications in an experimental model of metabolic syndrome.
Sormani LE, Cruzeiro J, Belin MAF, Dos Santos MPS, Siqueira JS, Vieira TA, Grandini NA, Tanganini MD, Palacio TLN, Romualdo GR, Aldini G, Corrêa CR. Sormani LE, et al. Mol Cell Endocrinol. 2026 Sep;619:112828. doi: 10.1016/j.mce.2026.112828. Epub 2026 May 15. Mol Cell Endocrinol. 2026. PMID: 42142734 Free article.
BACKGROUND: Metabolic syndrome (MetS) promotes skeletal muscle complications, which can impair glucose uptake and contribute to the development of diabetes. ...OBJECTIVE: To evaluate the effects of PBJ on skeletal muscle complications in an experimental model of …
BACKGROUND: Metabolic syndrome (MetS) promotes skeletal muscle complications, which can impair glucose uptake and contribute t …
Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome.
Parafati M, Lascala A, Morittu VM, Trimboli F, Rizzuto A, Brunelli E, Coscarelli F, Costa N, Britti D, Ehrlich J, Isidoro C, Mollace V, Janda E. Parafati M, et al. J Nutr Biochem. 2015 Sep;26(9):938-48. doi: 10.1016/j.jnutbio.2015.03.008. Epub 2015 Apr 28. J Nutr Biochem. 2015. PMID: 26025327
To address this hypothesis and analyze the underlying mechanisms, we supplemented bergamot polyphenol fraction (BPF) to cafeteria (CAF) diet-fed rats, a good model for pediatric metabolic syndrome and NAFLD. BPF treatment (50 mg/kg/day supplemented with drinking wat …
To address this hypothesis and analyze the underlying mechanisms, we supplemented bergamot polyphenol fraction (BPF) to cafeteria (CA …
The effect of bergamot polyphenolic fraction on lipid transfer protein system and vascular oxidative stress in a rat model of hyperlipemia.
Musolino V, Gliozzi M, Nucera S, Carresi C, Maiuolo J, Mollace R, Paone S, Bosco F, Scarano F, Scicchitano M, Ruga S, Zito MC, Colica C, Macrì R, Palma E, Ragusa S, Muscoli C, Mollace V. Musolino V, et al. Lipids Health Dis. 2019 May 17;18(1):115. doi: 10.1186/s12944-019-1061-0. Lipids Health Dis. 2019. PMID: 31101130 Free PMC article.
BACKGROUND: Experimental and epidemiological studies show that bergamot polyphenolic fraction (BPF) ameliorates the serum lipemic profile, normalizes blood pressure and improves non alcoholic fatty liver disease in patients suffering from metabolic syndrome. …
BACKGROUND: Experimental and epidemiological studies show that bergamot polyphenolic fraction (BPF) ameliorates the serum lipemic pro …
A new breakfast brioche containing bergamot fiber prevents insulin and glucose increase in healthy volunteers: a pilot study.
Mare R, Mazza E, Ferro Y, Gliozzi M, Nucera S, Paone S, Aversa I, Pujia R, Marafioti G, Musolino V, Mollace V, Montalcini T, Pujia A. Mare R, et al. Minerva Endocrinol (Torino). 2021 Jun;46(2):214-225. doi: 10.23736/S2724-6507.20.03243-5. Epub 2020 Sep 24. Minerva Endocrinol (Torino). 2021. PMID: 32969628
We aimed to investigate the feasibility of a new dietary approach in controlling glucose and insulin response at breakfast time by testing a brioche enriched with wheat bran and bergamot fiber. ...CONCLUSIONS: The association of wheat bran and bergamot fiber …
We aimed to investigate the feasibility of a new dietary approach in controlling glucose and insulin response at breakfast time by te …
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.
Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S, Muscoli C, Rotiroti D, Romeo F. Mollace V, et al. Fitoterapia. 2011 Apr;82(3):309-16. doi: 10.1016/j.fitote.2010.10.014. Epub 2010 Nov 4. Fitoterapia. 2011. PMID: 21056640 Clinical Trial.
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. ...BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a signif …
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. ...BPF, given orally for 30 days to both r …