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Comparative effect of a nutraceutical compound based on a flavonoid complex from bergamot on plasma lipids, glucose metabolism, and liver enzymes: a 3-arm, double-blind, placebo-controlled, randomized clinical trial.
Fogacci F, Di Micoli V, Veronesi M, Cicero AFG. Fogacci F, et al. Arch Med Sci. 2022 Sep 9;19(5):1180-1185. doi: 10.5114/aoms/152791. eCollection 2023. Arch Med Sci. 2022. PMID: 37732027 Free PMC article.
Thus, we carried out a randomized, double-blind, placebo-controlled clinical trial on 75 hypercholesterolaemic subjects randomized to take the active compound (2 tablets per day), placebo (2 tablets per day), or both (1 per product per day). ...CONCLUSIONS: the test …
Thus, we carried out a randomized, double-blind, placebo-controlled clinical trial on 75 hypercholesterolaemic subjects randomized
Artichoke and Bergamot Phytosome Alliance: A Randomized Double Blind Clinical Trial in Mild Hypercholesterolemia.
Riva A, Petrangolini G, Allegrini P, Perna S, Giacosa A, Peroni G, Faliva MA, Naso M, Rondanelli M. Riva A, et al. Nutrients. 2021 Dec 27;14(1):108. doi: 10.3390/nu14010108. Nutrients. 2021. PMID: 35010984 Free PMC article. Clinical Trial.
Botanicals are natural alternatives to pharmacological therapies that aim at reducing hypercholesterolemia. In this context, despite bergamot being effective in modulating lipid profile, some subjects failed to achieve a satisfactory response to supplementation. The …
Botanicals are natural alternatives to pharmacological therapies that aim at reducing hypercholesterolemia. In this context, despite berg
Effect of Citrus bergamia extract on lipid profile: A combined in vitro and human study.
Pierdomenico M, Cicero AFG, Veronesi M, Fogacci F, Riccioni C, Benassi B. Pierdomenico M, et al. Phytother Res. 2023 Sep;37(9):4185-4195. doi: 10.1002/ptr.7897. Epub 2023 Jun 13. Phytother Res. 2023. PMID: 37312672 Clinical Trial.
By stimulating the phosphorylation of AMP-activated protein kinase (AMPK) at threonine 172, Brumex significantly reduces both cholesterol and triglyceride (TG) intracellular content of HepG2 cells and impairs the expression levels of lipid synthesis-related genes ( …
By stimulating the phosphorylation of AMP-activated protein kinase (AMPK) at threonine 172, Brumex significantly reduces both cholestero
Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia.
Gliozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi C, Musolino V, Russo V, Janda E, Ragusa S, Aloe A, Palma E, Muscoli C, Romeo F, Mollace V. Gliozzi M, et al. Int J Cardiol. 2013 Dec 10;170(2):140-5. doi: 10.1016/j.ijcard.2013.08.125. Epub 2013 Sep 8. Int J Cardiol. 2013. PMID: 24239156 Clinical Trial.
We hypothesize that the use of natural bergamot-derived polyphenols may allow patients undergoing statin treatment to reduce effective doses while achieving target lipid values. ...RESULTS: Both doses of rosuvastatin and BPF reduced total cholesterol, LDL-C, …
We hypothesize that the use of natural bergamot-derived polyphenols may allow patients undergoing statin treatment to reduce effectiv …
Hypoglycemic and Hypolipemic Effects of a New Lecithin Formulation of Bergamot Polyphenolic Fraction: A Double Blind, Randomized, Placebo- Controlled Study.
Mollace V, Scicchitano M, Paone S, Casale F, Calandruccio C, Gliozzi M, Musolino V, Carresi C, Maiuolo J, Nucera S, Riva A, Allegrini P, Ronchi M, Petrangolini G, Bombardelli E. Mollace V, et al. Endocr Metab Immune Disord Drug Targets. 2019;19(2):136-143. doi: 10.2174/1871530319666181203151513. Endocr Metab Immune Disord Drug Targets. 2019. PMID: 30501605 Clinical Trial.
A randomized, double blind, placebo-controlled study was carried out in 60 patients suffering from type 2 DM and mixed hyperlipemia. ...RESULTS: In the groups receiving BPF and BPF Phyto, a significant reduction of fasting plasma glucose, serum LDL cholesterol and t …
A randomized, double blind, placebo-controlled study was carried out in 60 patients suffering from type 2 DM and mixed hyperlipemia. …
Effects of a novel nutraceutical combination (BruMeChol ) in subjects with mild hypercholesterolemia: study protocol of a randomized, double-blind, controlled trial.
Bonfigli AR, Protic O, Olivieri F, Montesanto A, Malatesta G, Di Pillo R, Antonicelli R. Bonfigli AR, et al. Trials. 2020 Jul 6;21(1):616. doi: 10.1186/s13063-020-04551-4. Trials. 2020. PMID: 32631422 Free PMC article.
Here, we describe the study protocol of a clinical trial aimed to evaluate the cholesterol and inflammatory lowering effect of an innovative dietary supplement (BruMeChol , Mivell S.r.l., Italy), composed of a mixture of extracts of bergamot and olive fruits in asso …
Here, we describe the study protocol of a clinical trial aimed to evaluate the cholesterol and inflammatory lowering effect of an inn …
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.
Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S, Muscoli C, Rotiroti D, Romeo F. Mollace V, et al. Fitoterapia. 2011 Apr;82(3):309-16. doi: 10.1016/j.fitote.2010.10.014. Epub 2010 Nov 4. Fitoterapia. 2011. PMID: 21056640 Clinical Trial.
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or n
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of b