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234,753 results

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Page 1
Plasma clearance.
Toutain PL, Bousquet-Mélou A. Toutain PL, et al. J Vet Pharmacol Ther. 2004 Dec;27(6):415-25. doi: 10.1111/j.1365-2885.2004.00605.x. J Vet Pharmacol Ther. 2004. PMID: 15601437 Review.
Plasma (total, systemic...) clearance is determined by all the individual metabolizing/eliminating organ clearances and involves mainly liver and kidney clearances. ...The interpretation of plasma clearance and inter-species comparisons are made easier …
Plasma (total, systemic...) clearance is determined by all the individual metabolizing/eliminating organ clearances and involv …
Enhancing dialyser clearance-from target to development.
Tangvoraphonkchai K, Davenport A. Tangvoraphonkchai K, et al. Pediatr Nephrol. 2017 Dec;32(12):2225-2233. doi: 10.1007/s00467-017-3647-y. Epub 2017 Apr 12. Pediatr Nephrol. 2017. PMID: 28401301 Review.
Therefore, newer approaches to standard dialysis practice are required to look beyond urea clearance. Current dialysers have been developed to effectively clear small solutes and secondly to increase middle-sized toxin clearances. ...The introduction of haemodiafilt …
Therefore, newer approaches to standard dialysis practice are required to look beyond urea clearance. Current dialysers have been dev …
Process and System Clearances in Pharmacokinetic Models: Our Basic Clearance Concepts Are Correct.
Korzekwa K, Nagar S. Korzekwa K, et al. Drug Metab Dispos. 2023 Apr;51(4):532-542. doi: 10.1124/dmd.122.001060. Epub 2023 Jan 9. Drug Metab Dispos. 2023. PMID: 36623886 Free PMC article. Review.
Clearances are important parameters in pharmacokinetic (PK) models. All clearances in PK models are either process clearances that include diffusion, transport, and metabolism clearances or system clearances that include organ and systemic cl …
Clearances are important parameters in pharmacokinetic (PK) models. All clearances in PK models are either process clearanc …
Increasing the Clearance of Protein-Bound Solutes by Recirculating Dialysate through Activated Carbon.
Meyer TW, Lee S, Whitmer LC, Blanco IJ, Suba JK, Sirich TL. Meyer TW, et al. Kidney360. 2023 Jun 1;4(6):e744-e750. doi: 10.34067/KID.0000000000000155. Epub 2023 May 22. Kidney360. 2023. PMID: 37211642 Free PMC article.
Chemical measurements tested the ability of the recirculating system to increase the clearance of selected solutes. Mathematical modeling predicted the dependence of solute clearances on the extent to which solutes were taken up by the carbon block and were bound to …
Chemical measurements tested the ability of the recirculating system to increase the clearance of selected solutes. Mathematical mode …
Augmenting solute clearance in peritoneal dialysis.
Krediet RT, Douma CE, van Olden RW, Ho-dac-Pannekeet MM, Struijk DG. Krediet RT, et al. Kidney Int. 1998 Dec;54(6):2218-25. doi: 10.1046/j.1523-1755.1998.00181.x. Kidney Int. 1998. PMID: 9853288 Free article. Review.
High dosages of furosemide increase the urinary volume and the fractional Na+ excretion, but have no effect on the magnitude of residual GFR, renal creatinine clearance, renal urea clearance, and peritoneal transport characteristics. The drained dialysate volume per …
High dosages of furosemide increase the urinary volume and the fractional Na+ excretion, but have no effect on the magnitude of residual GFR …
Residual Renal Phosphate Clearance in Patients Receiving Hemodialysis or Hemodiafiltration.
Hegbrant J, Bernat A, Del Castillo D, Pizarro JL, Caparros S, Gaspar M, Jarava C, Strippoli GFM, Daugirdas JT. Hegbrant J, et al. J Ren Nutr. 2023 Mar;33(2):326-331. doi: 10.1053/j.jrn.2022.06.006. Epub 2022 Jul 2. J Ren Nutr. 2023. PMID: 35792258
However, the relationships among residual renal urea, creatinine, and phosphate clearances, respectively, and between clearances and urine volume have not been well described. ...CONCLUSIONS: In maintenance hemodialysis and hemodiafiltration patients, residual renal …
However, the relationships among residual renal urea, creatinine, and phosphate clearances, respectively, and between clearances …
Metabolomic Profiling Identifies New Endogenous Markers of Tubular Secretory Clearance.
Granda ML, Prince DK, Fiehn O, Chen Y, Rajabi T, Yeung CK, Hoofnagle AN, Kestenbaum B. Granda ML, et al. Kidney360. 2023 Jan 1;4(1):23-31. doi: 10.34067/KID.0004172022. Kidney360. 2023. PMID: 36700901 Free PMC article.
We found seven highly (>50%) protein-bound and 49 poorly bound solutes with clearances significantly associated with furosemide clearance and 18 solute clearances favoring an association with furosemide clearance by the 90th percentile compared with …
We found seven highly (>50%) protein-bound and 49 poorly bound solutes with clearances significantly associated with furosemide …
Net Influx Rather Than Directional Rates: Re-evaluating Transporter Characterization In Vivo and In Vitro for Renal and Hepatic Clearance.
Benet LZ, Sodhi JK. Benet LZ, et al. AAPS J. 2025 Oct 23;28(1):3. doi: 10.1208/s12248-025-01161-3. AAPS J. 2025. PMID: 41131222 Free article. Review.
Here we challenge the assumption that hepatic uptake can be rate-limited solely by transporter-mediated influx clearance, as commonly concluded in interpretations based on the Extended Clearance Concept (ECC). ...This approach is analogous to the treatment of secret …
Here we challenge the assumption that hepatic uptake can be rate-limited solely by transporter-mediated influx clearance, as commonly …
Acetaminophen clearance during ex vivo continuous renal replacement therapies.
Scoville BA, Vulaj V, Mueller BA, Annich GM, Wagner DS. Scoville BA, et al. J Artif Organs. 2018 Jun;21(2):215-219. doi: 10.1007/s10047-017-1001-6. Epub 2017 Oct 23. J Artif Organs. 2018. PMID: 29063343
Transmembrane clearance was assessed using a validated ex vivo bovine blood model for CRRT using an F8 or HF1400 hemodiafilter. ...Acetaminophen clearance rates were 92-98% of ultrafiltrate production rates. Similarly, dialytic acetaminophen clearances approx …
Transmembrane clearance was assessed using a validated ex vivo bovine blood model for CRRT using an F8 or HF1400 hemodiafilter. ...Ac …
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