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Table representation of search results timeline featuring number of search results per year.

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1842 1
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1894 1
1895 1
1898 1
1899 2
1900 1
1901 1
1905 1
1907 2
1908 3
1909 1
1910 4
1911 2
1912 4
1913 5
1914 6
1915 5
1916 7
1917 13
1918 11
1919 11
1920 7
1921 8
1922 5
1923 6
1924 3
1925 8
1926 8
1927 10
1928 5
1929 4
1930 4
1931 3
1932 5
1933 9
1934 3
1935 2
1936 6
1937 6
1938 6
1939 1
1940 5
1941 2
1942 3
1943 5
1944 2
1945 9
1946 11
1947 13
1948 27
1949 35
1950 29
1951 35
1952 29
1953 46
1954 45
1955 59
1956 62
1957 80
1958 71
1959 88
1960 73
1961 70
1962 80
1963 89
1964 97
1965 100
1966 122
1967 119
1968 166
1969 150
1970 180
1971 177
1972 192
1973 211
1974 265
1975 1454
1976 1635
1977 1540
1978 1603
1979 1775
1980 1896
1981 2003
1982 2181
1983 2711
1984 2957
1985 3068
1986 3185
1987 3492
1988 3598
1989 4469
1990 4787
1991 4934
1992 5024
1993 5388
1994 5697
1995 6060
1996 6471
1997 6620
1998 7097
1999 7585
2000 8356
2001 8821
2002 9307
2003 10145
2004 10951
2005 11972
2006 13258
2007 13642
2008 14726
2009 15426
2010 16935
2011 18353
2012 20203
2013 21143
2014 22164
2015 22906
2016 23756
2017 24610
2018 25368
2019 26673
2020 30987
2021 33889
2022 33351
2023 31189
2024 31117
2025 35405
2026 16601
2027 1
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590,465 results

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Page 1
Cellular and Molecular Probing of Intact Human Organs.
Zhao S, Todorov MI, Cai R, -Maskari RA, Steinke H, Kemter E, Mai H, Rong Z, Warmer M, Stanic K, Schoppe O, Paetzold JC, Gesierich B, Wong MN, Huber TB, Duering M, Bruns OT, Menze B, Lipfert J, Puelles VG, Wolf E, Bechmann I, Ertürk A. Zhao S, et al. Cell. 2020 Feb 20;180(4):796-812.e19. doi: 10.1016/j.cell.2020.01.030. Epub 2020 Feb 13. Cell. 2020. PMID: 32059778 Free PMC article.
Optical tissue transparency permits scalable cellular and molecular investigation of complex tissues in 3D. ...Thereby, we revealed structural details of the intact human eye, human thyroid, human kidney, and transgenic pig pancreas at the cellular resolution. ...
Optical tissue transparency permits scalable cellular and molecular investigation of complex tissues in 3D. ...Thereby, we revealed s …
Recent progress in optical clearing of eye tissues.
Lu W, Pei Z, Hu W, Tan C, Tong X, Feng Y, Sun X. Lu W, et al. Exp Eye Res. 2021 Nov;212:108796. doi: 10.1016/j.exer.2021.108796. Epub 2021 Oct 15. Exp Eye Res. 2021. PMID: 34662543 Free article. Review.
In this review, we searched Medline and Embase for studies published between January 2006 and August 2021 using the terms "tissue optical clearing", "ophthalmology", "eye", and "optical clearing agents", and we reviewed the publications on the …
In this review, we searched Medline and Embase for studies published between January 2006 and August 2021 using the terms "tissue optical …
An ocular glymphatic clearance system removes beta-amyloid from the rodent eye.
Wang X, Lou N, Eberhardt A, Yang Y, Kusk P, Xu Q, Förstera B, Peng S, Shi M, Ladrón-de-Guevara A, Delle C, Sigurdsson B, Xavier ALR, Ertürk A, Libby RT, Chen L, Thrane AS, Nedergaard M. Wang X, et al. Sci Transl Med. 2020 Mar 25;12(536):eaaw3210. doi: 10.1126/scitranslmed.aaw3210. Sci Transl Med. 2020. PMID: 32213628 Free PMC article.
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. beta-amyloid (Abeta) was cleared from t …
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular gl …
Optical Clearing of Plant Tissues for Fluorescence Imaging.
Kurihara D, Mizuta Y, Nagahara S, Sato Y, Higashiyama T. Kurihara D, et al. J Vis Exp. 2022 Jan 5;(179). doi: 10.3791/63428. J Vis Exp. 2022. PMID: 35068484
A detailed protocol is provided here for the optical clearing of plant tissues using clearing reagents, ClearSee (CS) or ClearSeeAlpha (CSA). The preparation of cleared plant tissues involves three steps: fixation, washing, and clearing. Fixatio …
A detailed protocol is provided here for the optical clearing of plant tissues using clearing reagents, ClearSee (CS) o …
Optical Clearing Agents for Optical Imaging Through Cartilage Tympanoplasties: A Preclinical Feasibility Study.
Wang J, Chawdhary G, Yang X, Morin F, Khalid-Raja M, Farrell J, MacDougall D, Chen F, Morris DP, Adamson RBA. Wang J, et al. Otol Neurotol. 2022 Apr 1;43(4):e467-e474. doi: 10.1097/MAO.0000000000003502. Otol Neurotol. 2022. PMID: 35239620
HYPOTHESIS: Optical clearing agents (OCAs) can render cartilage tympanoplasty grafts sufficiently transparent to permit visualization of middle ear structures in an operated ear using optical coherence tomography (OCT) imaging. ...A reference reflector was im …
HYPOTHESIS: Optical clearing agents (OCAs) can render cartilage tympanoplasty grafts sufficiently transparent to permit visual …
Optical clearing with tartrazine enables deep transscleral imaging with optical coherence tomography.
Narawane A, Trout R, Viehland C, Kuo AN, Vajzovic L, Dhalla AH, Toth CA. Narawane A, et al. J Biomed Opt. 2024 Dec;29(12):120501. doi: 10.1117/1.JBO.29.12.120501. Epub 2024 Dec 9. J Biomed Opt. 2024. PMID: 39669907 Free PMC article.
APPROACH: We developed a custom handheld OCT scanner to image the anterior segment and suprachoroidal space in ex vivo eye models. Tartrazine (Yellow 5) solution, which has been shown to optically clear biological tissue in the visible regime, was tested as a …
APPROACH: We developed a custom handheld OCT scanner to image the anterior segment and suprachoroidal space in ex vivo eye models. Ta …
Optical clearing: impact of optical and dielectric properties of clearing solutions on pulmonary tissue mechanics.
Schwenninger D, Priebe HJ, Schneider M, Runck H, Guttmann J. Schwenninger D, et al. J Appl Physiol (1985). 2017 Jul 1;123(1):27-37. doi: 10.1152/japplphysiol.00234.2016. Epub 2017 Mar 30. J Appl Physiol (1985). 2017. PMID: 28360119 Free article.
A prerequisite, however, is the preservation of the native tissue mechanics of the optically cleared lung tissue. We investigated the impact of optical and dielectric properties of clearing solutions on biomechanics and clearing potency in porci …
A prerequisite, however, is the preservation of the native tissue mechanics of the optically cleared lung tissue. We investiga …
Axonal mitophagy in retinal ganglion cells.
Liang Y, Li Y, Jiao Q, Wei M, Wang Y, Cui A, Li Z, Li G. Liang Y, et al. Cell Commun Signal. 2024 Jul 29;22(1):382. doi: 10.1186/s12964-024-01761-0. Cell Commun Signal. 2024. PMID: 39075570 Free PMC article. Review.
When mitochondria within the axon are critically damaged beyond their compensatory capacity, they are cleared via autophagosomal phagocytosis, and the degradation products are recycled to replenish energy. ...Furthermore, abnormal axonal mitophagy is crucial in the pathoge …
When mitochondria within the axon are critically damaged beyond their compensatory capacity, they are cleared via autophagosomal phag …
TRPA1 exacerbates selective retinal ganglion cell vulnerability under acute ocular hypertension.
Lu W, Wang Y, Hu W, Lin X, Tong X, Tian Y, Chen Y, Wang Y, Xiao Y, Yang H, Feng Y, Sun X. Lu W, et al. Acta Neuropathol Commun. 2025 Apr 5;13(1):70. doi: 10.1186/s40478-025-01974-5. Acta Neuropathol Commun. 2025. PMID: 40186313 Free PMC article.
Further, by applying a modified whole-brain clearing method, the region-specific RGC axonal damage among lateral geniculate nuclei (LGN) subregions were adopted to detect the involvement of TRPA1 on selective RGC vulnerability. ...In virtue of our modified whole-brain c …
Further, by applying a modified whole-brain clearing method, the region-specific RGC axonal damage among lateral geniculate nuclei (L …
Evaluation of seven optical clearing methods in mouse brain.
Wan P, Zhu J, Xu J, Li Y, Yu T, Zhu D. Wan P, et al. Neurophotonics. 2018 Jul;5(3):035007. doi: 10.1117/1.NPh.5.3.035007. Epub 2018 Aug 25. Neurophotonics. 2018. PMID: 30155510 Free PMC article.
Combined with optical imaging techniques and diverse labeling methods, these clearing methods have significantly promoted the development of neuroscience. ...This study is expected to provide important reference for users in choosing the most suitable brain optic …
Combined with optical imaging techniques and diverse labeling methods, these clearing methods have significantly promoted the …
590,465 results
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