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Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.
Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S. Farooqi IS, et al. N Engl J Med. 2003 Mar 20;348(12):1085-95. doi: 10.1056/NEJMoa022050. N Engl J Med. 2003. PMID: 12646665 Free article.
BACKGROUND: Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form of obesity. ...METHODS: We determined the nucleotide sequence of the MC4R gene in 500 probands with severe childhood obesity. Family studies were undert …
BACKGROUND: Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form of obesity. ...METHODS: We …
Monogenic forms of obesity and diabetes mellitus.
Tsigos C, Kyrou I, Raptis SA. Tsigos C, et al. J Pediatr Endocrinol Metab. 2002 Mar;15(3):241-53. doi: 10.1515/JPEM.2002.15.3.241. J Pediatr Endocrinol Metab. 2002. PMID: 11924926 Review.
In humans, mutations in leptin, leptin receptor, proopiomelanocortin (POMC), melanocortin-4 receptor (MC4R) and prohormone convertase 1 (PC1) have been described in patients with severe obesity. ...At the other end of the spectrum
In humans, mutations in leptin, leptin receptor, proopiomelanocortin (POMC), melanocortin-4 receptor (MC4 …
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