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Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis.
Zewail MB, El-Gizawy SA, Asaad GF, Shabana ME, El-Dakroury WA. Zewail MB, et al. Int J Pharm. 2023 Aug 25;643:123224. doi: 10.1016/j.ijpharm.2023.123224. Epub 2023 Jul 12. Int J Pharm. 2023. PMID: 37451327
The appealing antirheumatic properties of both clove oil and chitosan (CS) were exploited to design oral leflunomide (LEF)-loaded nanoemulsion (NE) system to augment the therapeutic action of LEF and decrease its systemic side effects as well. Different LEF-NEs were …
The appealing antirheumatic properties of both clove oil and chitosan (CS) were exploited to design oral leflunomide (LEF)-loa …
Dual anti-inflammatory and immunomodulatory effects of clove essential oil and eugenol: targeting neutrophil functions and experimental arthritis.
El Faqer O, Ouadghiri Z, Wahnou H, Elkoraichi I, El Faqer A, Mazti A, Rais S, Mtairag EM. El Faqer O, et al. Inflammopharmacology. 2025 Dec 5. doi: 10.1007/s10787-025-02061-w. Online ahead of print. Inflammopharmacology. 2025. PMID: 41348260
This study aimed to evaluate the immunomodulatory and anti-arthritic effects of clove essential oil (CEO) and its main constituent, eugenol, through in vitro, in vivo, and in silico approaches. ...CEO and eugenol exert potent anti-inflammatory and immunomodulatory e …
This study aimed to evaluate the immunomodulatory and anti-arthritic effects of clove essential oil (CEO) and its main constit …
Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies.
Shakeel F, Alam P, Ali A, Alqarni MH, Alshetaili A, Ghoneim MM, Alshehri S, Ali A. Shakeel F, et al. Molecules. 2021 Dec 2;26(23):7327. doi: 10.3390/molecules26237327. Molecules. 2021. PMID: 34885909 Free PMC article.
The combined application of clove oil in a lipid nanocarrier opens a promising avenue for bone and joints therapy. In this study, we successfully developed a tunable controlled-release lipid platform for the efficient delivery of clove oil (CO) for the …
The combined application of clove oil in a lipid nanocarrier opens a promising avenue for bone and joints therapy. In this stu …
An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery.
Lal DK, Kumar B, Saeedan AS, Ansari MN. Lal DK, et al. Pharmaceutics. 2023 Apr 7;15(4):1187. doi: 10.3390/pharmaceutics15041187. Pharmaceutics. 2023. PMID: 37111672 Free PMC article. Review.
Moreover, oils that have anti-inflammatory properties, such as eucalyptus oil, emu oil and clove oil, are used as oil phases in the preparation of the nanoemulsion, which shows a synergistic effect with active moiety and enhances its overall the …
Moreover, oils that have anti-inflammatory properties, such as eucalyptus oil, emu oil and clove oil, are used a …
Targeting cardiovascular risk factors with eugenol: an anti-inflammatory perspective.
Devi S, Chauhan S, Mannan A, Singh TG. Devi S, et al. Inflammopharmacology. 2024 Feb;32(1):307-317. doi: 10.1007/s10787-023-01392-w. Epub 2023 Dec 12. Inflammopharmacology. 2024. PMID: 38085446 Review.
Eugenol is a natural phenolic compound found in clove oil, nutmeg oil, cinnamon oil, and bay leaf oil, as well as other essential oils. ...Various studies also suggest that eugenol can limit the production of inflammatory mediators such as prost …
Eugenol is a natural phenolic compound found in clove oil, nutmeg oil, cinnamon oil, and bay leaf oil, as …
Exploration of molecular interactions responsible for anti-inflammatory attributes of GI friendly micro-sized formulation of flurbiprofen and clove oil.
Zubair HM, Elsadek MF, Asghar S, Al-Numair KS, Saadullah M, Chaudhry SR, Efferth T, Asif M. Zubair HM, et al. Inflammopharmacology. 2025 Jan;33(1):241-256. doi: 10.1007/s10787-024-01611-y. Epub 2025 Jan 3. Inflammopharmacology. 2025. PMID: 39752039
Clove oil obtained from Syzygium aromaticum (L.) is traditionally employed to treat inflammation associated with rheumatism, gastric disorders, and as an analgesic. ...GC-MS of clove oil was performed to explore its chemical composition. FCM 25 mg/kg t …
Clove oil obtained from Syzygium aromaticum (L.) is traditionally employed to treat inflammation associated with rheumatism, g …
Design, Formulation, and Evaluation of Aloe vera Gel-Based Capsaicin Transemulgel for Osteoarthritis.
Rompicherla NC, Joshi P, Shetty A, Sudhakar K, Amin HIM, Mishra Y, Mishra V, Albutti A, Alhumeed N. Rompicherla NC, et al. Pharmaceutics. 2022 Aug 29;14(9):1812. doi: 10.3390/pharmaceutics14091812. Pharmaceutics. 2022. PMID: 36145560 Free PMC article.
The transemulgel was prepared from aqueous Aloe vera gel and Carbopol 934 with capsaicin in clove oil emulsion. The optimized transemulgel of capsaicin showed a pH of 6.1 0.1 and viscosity of 15263-998 cps. ...
The transemulgel was prepared from aqueous Aloe vera gel and Carbopol 934 with capsaicin in clove oil emulsion. The optimized …
Preparing a novel baicalin-loaded microemulsion-based gel for transdermal delivery and testing its anti-gout effect.
Wang Y, Liu M, Li J, Jiang P, Han D, Zhang H, Xu L, Qiu Y. Wang Y, et al. Saudi Pharm J. 2024 Jun;32(6):102100. doi: 10.1016/j.jsps.2024.102100. Epub 2024 May 14. Saudi Pharm J. 2024. PMID: 38812945 Free PMC article.
We previously demonstrated that baicalin had efficacy against gouty arthritis (GA) by oral administration. In this paper, a novel baicalin-loaded microemulsion-based gel (B-MEG) was prepared and assessed for the transdermal delivery of baicalin against GA. ...The optimized …
We previously demonstrated that baicalin had efficacy against gouty arthritis (GA) by oral administration. In this paper, a novel bai …
Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model.
Ferland CE, Beaudry F, Vachon P. Ferland CE, et al. Phytother Res. 2012 Sep;26(9):1278-85. doi: 10.1002/ptr.3725. Epub 2012 Jan 16. Phytother Res. 2012. PMID: 23015356
The aim of the present study was to evaluate whether eugenol, the main constituent of clove oil, has the capacity to provide analgesia in the monoiodoacetate-induced rat model of osteoarthritis. ...
The aim of the present study was to evaluate whether eugenol, the main constituent of clove oil, has the capacity to provide a …
Influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis rats.
Adefegha SA, Oyeleye SI, Okeke BM, Oboh G. Adefegha SA, et al. J Basic Clin Physiol Pharmacol. 2018 Nov 13;30(2):185-193. doi: 10.1515/jbcpp-2018-0060. J Basic Clin Physiol Pharmacol. 2018. PMID: 30422801
Background Eugenol is the foremost constituent of clove oil and widely distributed in many plants. It possesses many pharmaceutical applications, including antioxidant, anti-inflammatory, and anti-tumorigenic properties, among others. This study evaluates the influe …
Background Eugenol is the foremost constituent of clove oil and widely distributed in many plants. It possesses many pharmaceu …
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