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9,656 results

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Page 1
Mechanisms of clathrin-mediated endocytosis.
Kaksonen M, Roux A. Kaksonen M, et al. Nat Rev Mol Cell Biol. 2018 May;19(5):313-326. doi: 10.1038/nrm.2017.132. Epub 2018 Feb 7. Nat Rev Mol Cell Biol. 2018. PMID: 29410531 Review.
Since its discovery, over 50 proteins have been shown to be part of the molecular machinery that generates the clathrin-coated endocytic vesicles. These proteins and the different steps of the endocytic process that they mediate have been studied in detail. However, …
Since its discovery, over 50 proteins have been shown to be part of the molecular machinery that generates the clathrin-coated endocy …
Never Walk Alone: Clathrin-Coated Vesicle (CCV) Components in Plant Immunity.
Ekanayake G, LaMontagne ED, Heese A. Ekanayake G, et al. Annu Rev Phytopathol. 2019 Aug 25;57:387-409. doi: 10.1146/annurev-phyto-080417-045841. Epub 2019 Aug 6. Annu Rev Phytopathol. 2019. PMID: 31386597 Review.
These trafficking processes add or remove cargo proteins (such as pattern-recognition receptors, transporters, and other proteins with immune functions) to or from the PM via small, membrane-bound vesicles. Clathrin-coated vesicles (CCVs) that form at the PM …
These trafficking processes add or remove cargo proteins (such as pattern-recognition receptors, transporters, and other proteins with immun …
Mechanistic divergences of endocytic clathrin-coated vesicle formation in mammals, yeasts and plants.
Johnson A. Johnson A. J Cell Sci. 2024 Aug 15;137(16):jcs261847. doi: 10.1242/jcs.261847. Epub 2024 Aug 20. J Cell Sci. 2024. PMID: 39161994 Free PMC article. Review.
Clathrin-coated vesicles (CCVs), generated by clathrin-mediated endocytosis (CME), are essential eukaryotic trafficking organelles that transport extracellular and plasma membrane-bound materials into the cell. ...
Clathrin-coated vesicles (CCVs), generated by clathrin-mediated endocytosis (CME), are essential eukaryotic trafficking organe …
Clathrin-coated vesicle formation and protein sorting: an integrated process.
Schmid SL. Schmid SL. Annu Rev Biochem. 1997;66:511-48. doi: 10.1146/annurev.biochem.66.1.511. Annu Rev Biochem. 1997. PMID: 9242916 Review.
Clathrin-coated vesicles were the first discovered and remain the most extensively characterized transport vesicles. ...The functional interplay between the coated vesicle machinery and its cargo could ensure sorting fidelity and packaging effic …
Clathrin-coated vesicles were the first discovered and remain the most extensively characterized transport vesicles. .. …
COP-coated vesicles.
Gomez-Navarro N, Miller EA. Gomez-Navarro N, et al. Curr Biol. 2016 Jan 25;26(2):R54-R57. doi: 10.1016/j.cub.2015.12.017. Curr Biol. 2016. PMID: 26811885 Free article. Review.
Traffic of proteins within the secretory pathway is directed by cargo-bearing vesicles that transport proteins from one compartment to another. Key steps in vesicle-mediated trafficking include recruitment of specific cargo proteins, which must collect locally where …
Traffic of proteins within the secretory pathway is directed by cargo-bearing vesicles that transport proteins from one compartment t …
A structure-based mechanism for initiation of AP-3 coated vesicle formation.
Begley M, Aragon M, Baker RW. Begley M, et al. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2411974121. doi: 10.1073/pnas.2411974121. Epub 2024 Dec 20. Proc Natl Acad Sci U S A. 2024. PMID: 39705307 Free PMC article.
To reconstitute AP-3 activation by adenosine di-phosphate (ADP)-ribosylation factor 1 (Arf1), a small guanosine tri-phosphate (GTP)ase, we used lipid nanodiscs to build Arf1-AP-3 complexes on membranes and determined three structures showing the stepwise conformational changes re …
To reconstitute AP-3 activation by adenosine di-phosphate (ADP)-ribosylation factor 1 (Arf1), a small guanosine tri-phosphate (GTP)ase, we u …
Multi-modal adaptor-clathrin contacts drive coated vesicle assembly.
Smith SM, Larocque G, Wood KM, Morris KL, Roseman AM, Sessions RB, Royle SJ, Smith CJ. Smith SM, et al. EMBO J. 2021 Oct 1;40(19):e108795. doi: 10.15252/embj.2021108795. Epub 2021 Sep 6. EMBO J. 2021. PMID: 34487371 Free PMC article.
Clathrin-coated pits are formed by the recognition of membrane and cargo by the AP2 complex and the subsequent recruitment of clathrin triskelia. A role for AP2 in coated-pit assembly beyond initial clathrin recruitment has not been explored. Clathrin binds the beta …
Clathrin-coated pits are formed by the recognition of membrane and cargo by the AP2 complex and the subsequent recruitment of clathri …
Conserved functions of membrane active GTPases in coated vesicle formation.
Pucadyil TJ, Schmid SL. Pucadyil TJ, et al. Science. 2009 Sep 4;325(5945):1217-20. doi: 10.1126/science.1171004. Science. 2009. PMID: 19729648 Free PMC article. Review.
Coated vesicles concentrate and package cargo molecules to mediate their efficient transport between intracellular compartments. ...Recent evidence suggests that, although structurally diverse, Arf family GTPases and dynamin may play mechanistically similar roles as …
Coated vesicles concentrate and package cargo molecules to mediate their efficient transport between intracellular compartment …
Clathrin-coated vesicle formation: a paradigm for coated-vesicle formation.
Smythe E. Smythe E. Biochem Soc Trans. 2003 Jun;31(Pt 3):736-9. doi: 10.1042/bst0310736. Biochem Soc Trans. 2003. PMID: 12773195 Review.
Clathrin-coated pits are the major ports of entry into the cell and are responsible for the internalization of a variety of biologically important macromolecules. ...We have used a variety of approaches including permeabilized cell assays and light and electron microscopy …
Clathrin-coated pits are the major ports of entry into the cell and are responsible for the internalization of a variety of biologica …
RAB23 facilitates clathrin-coated nascent vesicle formation at the plasma membrane and modulates cell signaling.
Hasan MR, Takatalo M, Nieminen P, Rice R, Mustonen T, Rice DP. Hasan MR, et al. Cell Mol Life Sci. 2025 Apr 22;82(1):171. doi: 10.1007/s00018-025-05694-w. Cell Mol Life Sci. 2025. PMID: 40261407 Free PMC article.
Our results show that RAB23 might function at multiple steps during clathrin-coated nascent vesicle formation. We find that RAB23 interacts with clathrin assembly protein PICALM, vesicle curvature protein endophilin A2, and a protein linked with vesicle …
Our results show that RAB23 might function at multiple steps during clathrin-coated nascent vesicle formation. We find that RA …
9,656 results