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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
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132 results

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Page 1
Alpha-cobratoxin as a possible therapy for multiple sclerosis: a review of the literature leading to its development for this application.
Reid PF. Reid PF. Crit Rev Immunol. 2007;27(4):291-302. doi: 10.1615/critrevimmunol.v27.i4.10. Crit Rev Immunol. 2007. PMID: 18197810 Review.
The anecdotal reports for snake venom's beneficial effects in this condition may be supportable now by recent scientific evidence. Cobratoxin, a neurotoxin obtained from the venom of the Thailand cobra, has demonstrated several pharmacological activities that strongly supp …
The anecdotal reports for snake venom's beneficial effects in this condition may be supportable now by recent scientific evidence. Cobrat …
Peptide Inhibitors of the alpha-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B. Lynagh T, et al. J Med Chem. 2020 Nov 25;63(22):13709-13718. doi: 10.1021/acs.jmedchem.0c01202. Epub 2020 Nov 3. J Med Chem. 2020. PMID: 33143415 Free PMC article.
Combining high-throughput discovery and subsequent structure-function characterization, we present simple peptides that bind alpha-cobratoxin (alpha-Cbtx) and prevent its inhibition of nicotinic acetylcholine receptors (nAChRs) as a lead for the develo …
Combining high-throughput discovery and subsequent structure-function characterization, we present simple peptides that bind alpha-cobrat …
Virtual screening against alpha-cobratoxin.
Utsintong M, Talley TT, Taylor PW, Olson AJ, Vajragupta O. Utsintong M, et al. J Biomol Screen. 2009 Oct;14(9):1109-18. doi: 10.1177/1087057109344617. Epub 2009 Sep 4. J Biomol Screen. 2009. PMID: 19734437 Free PMC article.
alpha-Cobratoxin (Cbtx), the neurotoxin isolated from the venom of the Thai cobra Naja kaouthia , causes paralysis by preventing acetylcholine (ACh) binding to nicotinic acetylcholine receptors (nAChRs). In the current study, the region of the Cbtx mol …
alpha-Cobratoxin (Cbtx), the neurotoxin isolated from the venom of the Thai cobra Naja kaouthia , causes paralysis by preventing acet …
alpha-Conotoxins and alpha-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells.
Terpinskaya TI, Osipov AV, Kryukova EV, Kudryavtsev DS, Kopylova NV, Yanchanka TL, Palukoshka AF, Gondarenko EA, Zhmak MN, Tsetlin VI, Utkin YN. Terpinskaya TI, et al. Mar Drugs. 2021 Feb 21;19(2):118. doi: 10.3390/md19020118. Mar Drugs. 2021. PMID: 33669933 Free PMC article.
In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the arachidonic acid cascade are involved in oncogenesis. Although the engagement of the latter in survival and proliferation of rat C6 glioma has been show …
In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the arachidonic …
Computational insight into the peptide-based inhibition of alpha-cobratoxin.
Mitra A, Pandijothi V, Paul S. Mitra A, et al. Phys Chem Chem Phys. 2024 Nov 13;26(44):28274-28287. doi: 10.1039/d4cp03408b. Phys Chem Chem Phys. 2024. PMID: 39499553
The toxins released into the bloodstream of the victim bind to the nicotinic acetylcholine receptor and restrict transmission of nerve impulses leading to paralysis and cardiac arrest. ...Our study reveals that the inhibitor migrates close to Loop-II of alpha-cobratoxin …
The toxins released into the bloodstream of the victim bind to the nicotinic acetylcholine receptor and restrict transmission of nerv …
Dimeric alpha-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors.
Osipov AV, Rucktooa P, Kasheverov IE, Filkin SY, Starkov VG, Andreeva TV, Sixma TK, Bertrand D, Utkin YN, Tsetlin VI. Osipov AV, et al. J Biol Chem. 2012 Feb 24;287(9):6725-34. doi: 10.1074/jbc.M111.322313. Epub 2012 Jan 5. J Biol Chem. 2012. PMID: 22223648 Free PMC article.
Selective reduction of Cys(26)-Cys(30) in one protomer does not affect the activity against the alpha7 nicotinic acetylcholine receptor (nAChR), whereas its reduction in both protomers almost prevents alpha7 nAChR recognition. On the contrary, reduction of on …
Selective reduction of Cys(26)-Cys(30) in one protomer does not affect the activity against the alpha7 nicotinic acetylcholine recept …
A comparative study of the performance of E. coli and K. phaffii for expressing alpha-cobratoxin.
Damsbo A, Rimbault C, Burlet NJ, Vlamynck A, Bisbo I, Belfakir SB, Laustsen AH, Rivera-de-Torre E. Damsbo A, et al. Toxicon. 2024 Feb 23;239:107613. doi: 10.1016/j.toxicon.2024.107613. Epub 2024 Jan 11. Toxicon. 2024. PMID: 38218383 Free article.
In this study, we investigated the expression of alpha-cobratoxin, a well-characterized 3FTx from the monocled cobra (Naja kaouthia), in three different expression systems, namely Escherichia coli BL21 (DE3) cells with the csCyDisCo plasmid, Escherichia coli SHuffle cells, …
In this study, we investigated the expression of alpha-cobratoxin, a well-characterized 3FTx from the monocled cobra (Naja kaouthia), …
Three-finger proteins from snakes and humans acting on nicotinic receptors: Old and new.
Tsetlin VI, Kasheverov IE, Utkin YN. Tsetlin VI, et al. J Neurochem. 2021 Sep;158(6):1223-1235. doi: 10.1111/jnc.15123. Epub 2020 Jul 26. J Neurochem. 2021. PMID: 32648941 Review.
The first toxin to give rise to the three-finger protein (TFP) family was alpha-bungarotoxin (alpha-Bgt) from Bungarus multicinctus krait venom. alpha-Bgt was crucial for research on nicotinic acetylcholine receptors (nAChRs), and in this Review article we fo …
The first toxin to give rise to the three-finger protein (TFP) family was alpha-bungarotoxin (alpha-Bgt) from Bungarus multicinctus krait ve …
Protective immunity against alpha-cobratoxin following a single administration of a genetic vaccine encoding a non-toxic cobratoxin variant.
Pergolizzi RG, Dragos R, Ropper AE, Menez A, Crystal RG. Pergolizzi RG, et al. Hum Gene Ther. 2005 Mar;16(3):292-8. doi: 10.1089/hum.2005.16.292. Hum Gene Ther. 2005. PMID: 15812224
As a model for this approach, we developed a genetic vaccine to protect against alpha-cobratoxin (CTX), a potent, post-synaptic neurotoxin that is the major toxic component of the venom of Naja kaouthia, the monocellate cobra. ...Animals receiving AdmCTX but no alpha-co …
As a model for this approach, we developed a genetic vaccine to protect against alpha-cobratoxin (CTX), a potent, post-synaptic neuro …
Atypical Acetylcholine Receptors on the Neurons of the Turkish Snail.
Pivovarov AS, Palikhova TA, Nikolaev GM, Velikanov AN, Vasilieva NA, Kasheverov IE, Utkin YN, Tsetlin VI. Pivovarov AS, et al. Dokl Biochem Biophys. 2020 Mar;491(1):81-84. doi: 10.1134/S1607672920020118. Epub 2020 Jun 1. Dokl Biochem Biophys. 2020. PMID: 32483757
It was found that the alpha-conotoxin PnIA [R9, L10], a selective antagonist of alpha7 nAChR, and alpha-cobratoxin (antagonist of alpha7 and muscle-type nAChR) suppressed neuronal depolarization. ...In contrast to Lymnaea stagnalis nAChR, which are wea …
It was found that the alpha-conotoxin PnIA [R9, L10], a selective antagonist of alpha7 nAChR, and alpha-cobratoxin (antagonist …
132 results