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677 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial.
Sesso HD, Manson JE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, Copeland T, Clar A, Mora S, Moorthy MV, Sarkissian A, Carrick WR, Anderson GL; COSMOS Research Group. Sesso HD, et al. Am J Clin Nutr. 2022 Jun 7;115(6):1490-1500. doi: 10.1093/ajcn/nqac055. Am J Clin Nutr. 2022. PMID: 35294962 Free PMC article. Clinical Trial.
OBJECTIVES: We examined whether cocoa extract supplementation decreases total cardiovascular disease (CVD) among older adults. ...The intervention phase was June 2015 through December 2020. This article reports on the cocoa extract intervention. Participants were ra …
OBJECTIVES: We examined whether cocoa extract supplementation decreases total cardiovascular disease (CVD) among older adults. ...The …
Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial.
Baker LD, Manson JE, Rapp SR, Sesso HD, Gaussoin SA, Shumaker SA, Espeland MA. Baker LD, et al. Alzheimers Dement. 2023 Apr;19(4):1308-1319. doi: 10.1002/alz.12767. Epub 2022 Sep 14. Alzheimers Dement. 2023. PMID: 36102337 Free PMC article. Clinical Trial.
COSMOS-Mind tested whether daily administration of cocoa extract (containing 500 mg/day flavanols) versus placebo and a commercial multivitamin-mineral (MVM) versus placebo improved cognition in older women and men. ...Multivitamin-mineral benefits were also observed for m …
COSMOS-Mind tested whether daily administration of cocoa extract (containing 500 mg/day flavanols) versus placebo and a commercial mu …
Consumption of 85% cocoa dark chocolate improves mood in association with gut microbial changes in healthy adults: a randomized controlled trial.
Shin JH, Kim CS, Cha J, Kim S, Lee S, Chae S, Chun WY, Shin DM. Shin JH, et al. J Nutr Biochem. 2022 Jan;99:108854. doi: 10.1016/j.jnutbio.2021.108854. Epub 2021 Sep 14. J Nutr Biochem. 2022. PMID: 34530112 Free article. Clinical Trial.
Dark chocolate has long been recognized for its mood-altering properties; however, the evidence regarding the emotional effects of daily dark chocolate intake is limited. ...Two different dark chocolates (85% and 70% cocoa content) were tested in this study. …
Dark chocolate has long been recognized for its mood-altering properties; however, the evidence regarding the emotional effects of da …
Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS.
Vyas CM, Manson JE, Sesso HD, Cook NR, Rist PM, Weinberg A, Moorthy MV, Baker LD, Espeland MA, Yeung LK, Brickman AM, Okereke OI. Vyas CM, et al. Am J Clin Nutr. 2024 Mar;119(3):692-701. doi: 10.1016/j.ajcnut.2023.12.011. Epub 2024 Jan 18. Am J Clin Nutr. 2024. PMID: 38244989
OBJECTIVES: This study aimed to test MVM effects on cognitive change using in-person, detailed neuropsychological assessments and conduct a meta-analysis within COSMOS (COcoa Supplement and Multivitamin Outcomes Study) cognitive substudies for a robust evaluation of MVM ef …
OBJECTIVES: This study aimed to test MVM effects on cognitive change using in-person, detailed neuropsychological assessments and conduct a …
Effects of Cocoa Consumption on Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials.
Arisi TOP, da Silva DS, Stein E, Weschenfelder C, de Oliveira PC, Marcadenti A, Lehnen AM, Waclawovsky G. Arisi TOP, et al. Nutrients. 2024 Jun 18;16(12):1919. doi: 10.3390/nu16121919. Nutrients. 2024. PMID: 38931273 Free PMC article. Review.
The eligible studies were randomized clinical trials (RCTs) involving adults undergoing cocoa consumption (cocoa extract or 70% cocoa dark chocolate) for 4 weeks that evaluated at least one of the following markers: body weight, body mass index (BMI), …
The eligible studies were randomized clinical trials (RCTs) involving adults undergoing cocoa consumption (cocoa extract or 70 …
Cocoa flavanols, Nrf2 activation, and oxidative stress in peripheral artery disease: mechanistic findings in muscle based on outcomes from a randomized trial.
Ismaeel A, McDermott MM, Joshi JK, Sturgis JC, Zhang D, Ho KJ, Sufit R, Ferrucci L, Peterson CA, Kosmac K. Ismaeel A, et al. Am J Physiol Cell Physiol. 2024 Feb 1;326(2):C589-C605. doi: 10.1152/ajpcell.00573.2023. Epub 2024 Jan 8. Am J Physiol Cell Physiol. 2024. PMID: 38189132 Clinical Trial.
Epicatechin (EPI), a naturally occurring flavanol, has antioxidant properties that may mediate the beneficial effects of natural products such as cocoa. In a phase II randomized trial, a cocoa-flavanol-rich beverage significantly improved walking performance compare …
Epicatechin (EPI), a naturally occurring flavanol, has antioxidant properties that may mediate the beneficial effects of natural products su …
The effect of cocoa/dark chocolate consumption on lipid profile, glycemia, and blood pressure in diabetic patients: A meta-analysis of observational studies.
Darand M, Hajizadeh Oghaz M, Hadi A, Atefi M, Amani R. Darand M, et al. Phytother Res. 2021 Oct;35(10):5487-5501. doi: 10.1002/ptr.7183. Epub 2021 Jun 5. Phytother Res. 2021. PMID: 34089280 Review.
All randomized controlled trials (RCTs) using cocoa/dark chocolate in diabetic patients were included in the study. The search results were limited to English-language publications. ...However, further high quality trials are essential for confirming the clinical ef …
All randomized controlled trials (RCTs) using cocoa/dark chocolate in diabetic patients were included in the study. The search …
Cocoa flavanols protect cognitive function, cerebral oxygenation, and mental fatigue during severe hypoxia.
Bloomfield PM, Fisher JP, Shaw DM, Gant N. Bloomfield PM, et al. J Appl Physiol (1985). 2023 Aug 1;135(2):475-484. doi: 10.1152/japplphysiol.00219.2023. Epub 2023 Jul 20. J Appl Physiol (1985). 2023. PMID: 37471213 Free article. Clinical Trial.
We tested the hypothesis that ingestion of cocoa flavanols would improve cognition during acute hypoxia equivalent to 5,500 m altitude (partial pressure of end-tidal oxygen = 45 mmHg). ...Cocoa flavanols did not improve cognition during severe isocapnic hypoxia, sug …
We tested the hypothesis that ingestion of cocoa flavanols would improve cognition during acute hypoxia equivalent to 5,500 m altitud …
Cocoa Extract Supplementation and Risk of Type 2 Diabetes: The Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) Randomized Clinical Trial.
Li J, Sesso HD, Kim E, Manson JE, Friedenberg G, Clar A, Copeland T, Shadyab AH, Wactawski-Wende J, Tinker L, Liu S. Li J, et al. Diabetes Care. 2023 Dec 1;46(12):2278-2284. doi: 10.2337/dc23-1012. Diabetes Care. 2023. PMID: 37816167 Free PMC article. Clinical Trial.
OBJECTIVE: Observational studies have indicated that cocoa flavanol supplementation may be a promising strategy for type 2 diabetes (T2D) prevention. ...A total of 21,442 U.S. adults free of CVD and recent cancer, including 12,666 women aged 65 years and 8,776 men aged 60 …
OBJECTIVE: Observational studies have indicated that cocoa flavanol supplementation may be a promising strategy for type 2 diabetes ( …
Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Lin X, Zhang I, Li A, Manson JE, Sesso HD, Wang L, Liu S. Lin X, et al. J Nutr. 2016 Nov;146(11):2325-2333. doi: 10.3945/jn.116.237644. Epub 2016 Sep 28. J Nutr. 2016. PMID: 27683874 Free PMC article. Review.
BACKGROUND: Cocoa flavanols may improve cardiometabolic health. Evidence from small short-term randomized clinical trials (RCTs) remains inconsistent, and large long-term RCTs testing the efficacy of cocoa flavanols are still lacking. ...None of the modifiers seemed …
BACKGROUND: Cocoa flavanols may improve cardiometabolic health. Evidence from small short-term randomized clinical trials (RCTs) rema …
677 results

Searches related to "cocoa"