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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1981 2
1982 2
1983 2
1985 1
1986 2
1987 3
1990 4
1991 4
1992 1
1993 3
1994 7
1995 1
1996 3
1997 5
1998 4
1999 5
2000 7
2001 7
2002 5
2003 10
2004 9
2005 11
2006 17
2007 24
2008 23
2009 28
2010 34
2011 37
2012 45
2013 44
2014 43
2015 47
2016 44
2017 43
2018 50
2019 44
2020 47
2021 38
2022 40
2023 27
2024 2

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658 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial.
Baker LD, Manson JE, Rapp SR, Sesso HD, Gaussoin SA, Shumaker SA, Espeland MA. Baker LD, et al. Alzheimers Dement. 2023 Apr;19(4):1308-1319. doi: 10.1002/alz.12767. Epub 2022 Sep 14. Alzheimers Dement. 2023. PMID: 36102337 Free PMC article. Clinical Trial.
Using intention-to-treat, the primary endpoint was change in this composite with 3 years of cocoa extract use. The pre-specified secondary endpoint was change in the composite with 3 years of MVM supplementation. ...Multivitamin-mineral benefits were also observed for memo …
Using intention-to-treat, the primary endpoint was change in this composite with 3 years of cocoa extract use. The pre-specified seco …
Consumption of 85% cocoa dark chocolate improves mood in association with gut microbial changes in healthy adults: a randomized controlled trial.
Shin JH, Kim CS, Cha L, Kim S, Lee S, Chae S, Chun WY, Shin DM. Shin JH, et al. J Nutr Biochem. 2022 Jan;99:108854. doi: 10.1016/j.jnutbio.2021.108854. Epub 2021 Sep 14. J Nutr Biochem. 2022. PMID: 34530112 Free article. Clinical Trial.
Dark chocolate has long been recognized for its mood-altering properties; however, the evidence regarding the emotional effects of daily dark chocolate intake is limited. ...Two different dark chocolates (85% and 70% cocoa content) were tested in this study. …
Dark chocolate has long been recognized for its mood-altering properties; however, the evidence regarding the emotional effects of da …
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial.
Sesso HD, Manson JE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, Copeland T, Clar A, Mora S, Moorthy MV, Sarkissian A, Carrick WR, Anderson GL; COSMOS Research Group. Sesso HD, et al. Am J Clin Nutr. 2022 Jun 7;115(6):1490-1500. doi: 10.1093/ajcn/nqac055. Am J Clin Nutr. 2022. PMID: 35294962 Free PMC article. Clinical Trial.
OBJECTIVES: We examined whether cocoa extract supplementation decreases total cardiovascular disease (CVD) among older adults. ...The intervention phase was June 2015 through December 2020. This article reports on the cocoa extract intervention. Participants were ra …
OBJECTIVES: We examined whether cocoa extract supplementation decreases total cardiovascular disease (CVD) among older adults. ...The …
Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS.
Vyas CM, Manson JE, Sesso HD, Cook NR, Rist PM, Weinberg A, Moorthy MV, Baker LD, Espeland MA, Yeung LK, Brickman AM, Okereke OI. Vyas CM, et al. Am J Clin Nutr. 2024 Mar;119(3):692-701. doi: 10.1016/j.ajcnut.2023.12.011. Epub 2024 Jan 18. Am J Clin Nutr. 2024. PMID: 38244989
OBJECTIVES: This study aimed to test MVM effects on cognitive change using in-person, detailed neuropsychological assessments and conduct a meta-analysis within COSMOS (COcoa Supplement and Multivitamin Outcomes Study) cognitive substudies for a robust evaluation of MVM ef …
OBJECTIVES: This study aimed to test MVM effects on cognitive change using in-person, detailed neuropsychological assessments and conduct a …
Effect of cocoa on blood pressure.
Ried K, Fakler P, Stocks NP. Ried K, et al. Cochrane Database Syst Rev. 2017 Apr 25;4(4):CD008893. doi: 10.1002/14651858.CD008893.pub3. Cochrane Database Syst Rev. 2017. PMID: 28439881 Free PMC article. Review.
Here we update previous meta-analyses on the effect of cocoa on blood pressure. OBJECTIVES: To assess the effects on blood pressure of chocolate or cocoa products versus low-flavanol products or placebo in adults with or without hypertension when consumed for …
Here we update previous meta-analyses on the effect of cocoa on blood pressure. OBJECTIVES: To assess the effects on blood pressure o …
Cocoa Extract Supplementation and Risk of Type 2 Diabetes: The Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) Randomized Clinical Trial.
Li J, Sesso HD, Kim E, Manson JE, Friedenberg G, Clar A, Copeland T, Shadyab AH, Wactawski-Wende J, Tinker L, Liu S. Li J, et al. Diabetes Care. 2023 Dec 1;46(12):2278-2284. doi: 10.2337/dc23-1012. Diabetes Care. 2023. PMID: 37816167 Clinical Trial.
OBJECTIVE: Observational studies have indicated that cocoa flavanol supplementation may be a promising strategy for type 2 diabetes (T2D) prevention. ...A total of 21,442 U.S. adults free of CVD and recent cancer, including 12,666 women aged 65 years and 8,776 men aged 60 …
OBJECTIVE: Observational studies have indicated that cocoa flavanol supplementation may be a promising strategy for type 2 diabetes ( …
Cocoa flavanols protect cognitive function, cerebral oxygenation, and mental fatigue during severe hypoxia.
Bloomfield PM, Fisher JP, Shaw DM, Gant N. Bloomfield PM, et al. J Appl Physiol (1985). 2023 Aug 1;135(2):475-484. doi: 10.1152/japplphysiol.00219.2023. Epub 2023 Jul 20. J Appl Physiol (1985). 2023. PMID: 37471213 Clinical Trial.
We tested the hypothesis that ingestion of cocoa flavanols would improve cognition during acute hypoxia equivalent to 5,500 m altitude (partial pressure of end-tidal oxygen = 45 mmHg). ...Cocoa flavanols did not improve cognition during severe isocapnic hypoxia, sug …
We tested the hypothesis that ingestion of cocoa flavanols would improve cognition during acute hypoxia equivalent to 5,500 m altitud …
Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial.
Simpson EJ, Mendis B, Dunlop M, Schroeter H, Kwik-Uribe C, Macdonald IA. Simpson EJ, et al. Nutrients. 2023 Jan 21;15(3):565. doi: 10.3390/nu15030565. Nutrients. 2023. PMID: 36771271 Free PMC article. Clinical Trial.
There is interest in the impact that dietary interventions can have on preventing the transition from insulin resistance to type 2 diabetes, including a suggestion that the bioactive components of cocoa may enhance fasting insulin sensitivity. However, a role for cocoa
There is interest in the impact that dietary interventions can have on preventing the transition from insulin resistance to type 2 diabetes, …
Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Lin X, Zhang I, Li A, Manson JE, Sesso HD, Wang L, Liu S. Lin X, et al. J Nutr. 2016 Nov;146(11):2325-2333. doi: 10.3945/jn.116.237644. Epub 2016 Sep 28. J Nutr. 2016. PMID: 27683874 Free PMC article. Review.
BACKGROUND: Cocoa flavanols may improve cardiometabolic health. Evidence from small short-term randomized clinical trials (RCTs) remains inconsistent, and large long-term RCTs testing the efficacy of cocoa flavanols are still lacking. ...Cocoa flavanol intake …
BACKGROUND: Cocoa flavanols may improve cardiometabolic health. Evidence from small short-term randomized clinical trials (RCTs) rema …
The effect of cocoa/dark chocolate consumption on lipid profile, glycemia, and blood pressure in diabetic patients: A meta-analysis of observational studies.
Darand M, Hajizadeh Oghaz M, Hadi A, Atefi M, Amani R. Darand M, et al. Phytother Res. 2021 Oct;35(10):5487-5501. doi: 10.1002/ptr.7183. Epub 2021 Jun 5. Phytother Res. 2021. PMID: 34089280 Review.
Pooled analysis indicated a significant reduction in low-density lipoprotein cholesterol LDL-c levels (WMD: -15.49 mg/dl; 95% CI: -24.56, -6.42, p = .001) and fasting blood sugar (FBS) concentrations (WMD: -6.88 mg/dl; 95% CI: -13.28, -0.48, p = .03) following cocoa/dark …
Pooled analysis indicated a significant reduction in low-density lipoprotein cholesterol LDL-c levels (WMD: -15.49 mg/dl; 95% CI: -24.56, -6 …
658 results