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Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS.
Vyas CM, Manson JE, Sesso HD, Cook NR, Rist PM, Weinberg A, Moorthy MV, Baker LD, Espeland MA, Yeung LK, Brickman AM, Okereke OI. Vyas CM, et al. Am J Clin Nutr. 2024 Mar;119(3):692-701. doi: 10.1016/j.ajcnut.2023.12.011. Epub 2024 Jan 18. Am J Clin Nutr. 2024. PMID: 38244989 Free PMC article.
For the meta-analysis, we included nonoverlapping participants across 3 COSMOS cognitive substudies: COSMOS-Clinic (n = 573); COSMOS-Mind (n = 2158); COSMOS-Web (n = 2472). ...The meta-analysis within COSMOS cognitive substudies in …
For the meta-analysis, we included nonoverlapping participants across 3 COSMOS cognitive substudies: COSMOS-Clinic (n = …
Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial.
Baker LD, Manson JE, Rapp SR, Sesso HD, Gaussoin SA, Shumaker SA, Espeland MA. Baker LD, et al. Alzheimers Dement. 2023 Apr;19(4):1308-1319. doi: 10.1002/alz.12767. Epub 2022 Sep 14. Alzheimers Dement. 2023. PMID: 36102337 Free PMC article. Clinical Trial.
INTRODUCTION: Dietary supplements are touted for cognitive protection, but supporting evidence is mixed. COSMOS-Mind tested whether daily administration of cocoa extract (containing 500 mg/day flavanols) versus placebo and a commercial multivitamin-mineral (M …
INTRODUCTION: Dietary supplements are touted for cognitive protection, but supporting evidence is mixed. COSMOS-Mind tested wh …
Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial.
Vyas CM, Manson JE, Sesso HD, Rist PM, Weinberg A, Kim E, Moorthy MV, Cook NR, Okereke OI. Vyas CM, et al. Am J Clin Nutr. 2024 Jan;119(1):39-48. doi: 10.1016/j.ajcnut.2023.10.031. Epub 2023 Dec 7. Am J Clin Nutr. 2024. PMID: 38070683 Free PMC article. Clinical Trial.
BACKGROUND: Some prior randomized clinical trials (RCTs) that tested the effects of cocoa extract (CE), a source of flavanols, on late-life cognition have yielded promising findings. ...There were 573 participants in the clinic subcohort of COSMOS (that is, …
BACKGROUND: Some prior randomized clinical trials (RCTs) that tested the effects of cocoa extract (CE), a source of flavanols, on lat …
Impact of multivitamin-mineral and cocoa extract on incidence of mild cognitive impairment and dementia: Results from the COcoa Supplement and Multivitamin Outcomes Study for the Mind (COSMOS-Mind).
Sachs BC, Williams BJ, Gaussoin SA, Baker LD, Manson JE, Espeland MA, Sesso HD, Shumaker SA, Rapp SR; COSMOS-Mind Research Group. Sachs BC, et al. Alzheimers Dement. 2023 Nov;19(11):4863-4871. doi: 10.1002/alz.13078. Epub 2023 Apr 10. Alzheimers Dement. 2023. PMID: 37035889 Free PMC article. Clinical Trial.
INTRODUCTION: We assessed the effects of multivitamin-mineral and cocoa extract supplementation on incident mild cognitive impairment (MCI) and all-cause probable dementia. ...HIGHLIGHTS: Multivitamin-mineral supplementation did not reduce risks for cognitive …
INTRODUCTION: We assessed the effects of multivitamin-mineral and cocoa extract supplementation on incident mild cognitive imp …
Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption.
Brickman AM, Yeung LK, Alschuler DM, Ottaviani JI, Kuhnle GGC, Sloan RP, Luttmann-Gibson H, Copeland T, Schroeter H, Sesso HD, Manson JE, Wall M, Small SA. Brickman AM, et al. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2216932120. doi: 10.1073/pnas.2216932120. Epub 2023 May 30. Proc Natl Acad Sci U S A. 2023. PMID: 37252983 Free PMC article. Clinical Trial.
Dietary flavanols are food constituents found in certain fruits and vegetables that have been linked to cognitive aging. Previous studies suggested that consumption of dietary flavanols might specifically be associated with the hippocampal-dependent memory component of …
Dietary flavanols are food constituents found in certain fruits and vegetables that have been linked to cognitive aging. Previous stu …
Design and baseline characteristics of the cocoa supplement and multivitamin outcomes study for the Mind: COSMOS-Mind.
Baker LD, Rapp SR, Shumaker SA, Manson JE, Sesso HD, Gaussoin SA, Harris D, Caudle B, Pleasants D, Espeland MA; COSMOS-Mind Research Group. Baker LD, et al. Contemp Clin Trials. 2019 Aug;83:57-63. doi: 10.1016/j.cct.2019.06.019. Epub 2019 Jul 2. Contemp Clin Trials. 2019. PMID: 31271875 Free PMC article.
COSMOS is assessing whether cocoa extract (including 600 mg/d cocoa flavanols) and a multivitamin reduce risks for major cardiovascular events and total invasive cancer. COSMOS-Mind uses telephone-based interviews to assess cognitive function an …
COSMOS is assessing whether cocoa extract (including 600 mg/d cocoa flavanols) and a multivitamin reduce risks for majo …
Effects of pistachio consumption on cognition, cardiometabolic risk factors, and life satisfaction in older adults: Protocol for a remote-based randomized controlled trial.
Park SJ, Gavilan IS, Li S, Clar A, Lau J, Karbowski GC, Sarkissian AA, Cámara M, Sesso HD. Park SJ, et al. Contemp Clin Trials. 2026 Jun;165:108316. doi: 10.1016/j.cct.2026.108316. Epub 2026 Apr 15. Contemp Clin Trials. 2026. PMID: 41991057
BACKGROUND: Pistachios contain key nutrients and bioactive compounds that may be particularly relevant for cognition health. Although short-term pistachio intervention trials have demonstrated improvements in cardiometabolic risk factors implicated in cognitive decl …
BACKGROUND: Pistachios contain key nutrients and bioactive compounds that may be particularly relevant for cognition health. Although …
Multivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial.
Yeung LK, Alschuler DM, Wall M, Luttmann-Gibson H, Copeland T, Hale C, Sloan RP, Sesso HD, Manson JE, Brickman AM. Yeung LK, et al. Am J Clin Nutr. 2023 Jul;118(1):273-282. doi: 10.1016/j.ajcnut.2023.05.011. Epub 2023 May 24. Am J Clin Nutr. 2023. PMID: 37244291 Free PMC article. Clinical Trial.
BACKGROUND: Maintenance of cognitive abilities is of critical importance to older adults, yet few effective strategies to slow cognitive decline currently exist. ...METHODS: The COcoa Supplement and Multivitamin Outcomes Study Web (COSMOS-Web) ancillar …
BACKGROUND: Maintenance of cognitive abilities is of critical importance to older adults, yet few effective strategies to slow cog …