Physiologically Based Modelling of Darunavir/Ritonavir Pharmacokinetics During Pregnancy.
Clin Pharmacokinet. 2016 Mar;55(3):381-96. doi: 10.1007/s40262-015-0325-8.
Clin Pharmacokinet. 2016.
PMID: 26369773
Free PMC article.
Here, we used mechanistic modelling to delineate the potential impact of drug transporters on darunavir pharmacokinetics and to identify current knowledge gaps that limit accurate PBPK modelling of darunavir/ritonavir (darunavir/r) exposure in pregnancy. ...I …
Here, we used mechanistic modelling to delineate the potential impact of drug transporters on darunavir pharmacokinetics and to ident …