Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator.
Front Physiol. 2017 Oct 4;8:757. doi: 10.3389/fphys.2017.00757. eCollection 2017.
Front Physiol. 2017.
PMID: 29046643
Free PMC article.
We used these models to examine the efficacy of the hERG activator MC-II-157c in restoring APD to control ranges, examined its effects on arrhythmia triggers and substrates, and the interaction of these arrhythmia triggers and substrates. ...Conclusion …
We used these models to examine the efficacy of the hERG activator MC-II-157c in restoring APD to control ranges, examined its effects on ar …