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Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator.
Colman MA, Perez Alday EA, Holden AV, Benson AP. Colman MA, et al. Front Physiol. 2017 Oct 4;8:757. doi: 10.3389/fphys.2017.00757. eCollection 2017. Front Physiol. 2017. PMID: 29046643 Free PMC article.
We used these models to examine the efficacy of the hERG activator MC-II-157c in restoring APD to control ranges, examined its effects on arrhythmia triggers and substrates, and the interaction of these arrhythmia triggers and substrates. ...Conclusion …
We used these models to examine the efficacy of the hERG activator MC-II-157c in restoring APD to control ranges, examined its effects on ar …
Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation.
Colman MA. Colman MA. PLoS Comput Biol. 2019 Aug 8;15(8):e1007260. doi: 10.1371/journal.pcbi.1007260. eCollection 2019 Aug. PLoS Comput Biol. 2019. PMID: 31393876 Free PMC article.
Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid arrhythmias associated with conditions such as heart failure and atrial fibrillation: they can underlie the emergence of spontaneous action potentials in single cells which can l
Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid arrhythmias associated with conditions such a