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Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator.
Colman MA, Perez Alday EA, Holden AV, Benson AP. Colman MA, et al. Front Physiol. 2017 Oct 4;8:757. doi: 10.3389/fphys.2017.00757. eCollection 2017. Front Physiol. 2017. PMID: 29046643 Free PMC article.
We used these models to examine the efficacy of the hERG activator MC-II-157c in restoring APD to control ranges, examined its effects on arrhythmia triggers and substrates, and the interaction of these arrhythmia triggers and substrates. ...Conclusion …
We used these models to examine the efficacy of the hERG activator MC-II-157c in restoring APD to control ranges, examined its effects on ar …
Patchy fibrosis promotes trigger-substrate interactions that both generate and maintain atrial fibrillation.
Colman MA, Sharma R, Aslanidi OV, Zhao J. Colman MA, et al. Interface Focus. 2023 Dec 15;13(6):20230041. doi: 10.1098/rsfs.2023.0041. eCollection 2023 Dec 6. Interface Focus. 2023. PMID: 38106913 Free PMC article.
However, few studies have investigated the role of fibrosis in the generation of AF triggers in detail. We apply our in-house computational framework to study the impact of fibrosis on the generation of AF triggers and trigger-substrate interactions in …
However, few studies have investigated the role of fibrosis in the generation of AF triggers in detail. We apply our in-house computa …
Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation.
Colman MA. Colman MA. PLoS Comput Biol. 2019 Aug 8;15(8):e1007260. doi: 10.1371/journal.pcbi.1007260. eCollection 2019 Aug. PLoS Comput Biol. 2019. PMID: 31393876 Free PMC article.
Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid arrhythmias associated with conditions such as heart failure and atrial fibrillation: they can underlie the emergence of spontaneous action potentials in single cells which can l
Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid arrhythmias associated with conditions such a
Interactions between calcium-induced arrhythmia triggers and the electrophysiological-anatomical substrate underlying the induction of atrial fibrillation.
Colman MA, Varela M, MacLeod RS, Hancox JC, Aslanidi OV. Colman MA, et al. J Physiol. 2024 Feb 19. doi: 10.1113/JP285740. Online ahead of print. J Physiol. 2024. PMID: 38372694
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is sustained by spontaneous focal excitations and re-entry. Spontaneous electrical firing in the pulmonary vein (PV) sleeves is implicated in AF generation. ...Thus, a reduced I(K1) , less negative r …
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is sustained by spontaneous focal excitations and re-entry. Spo