Combination treatment with T4 and T3: toward personalized replacement therapy in hypothyroidism?
J Clin Endocrinol Metab. 2012.
PMID: 22593590
Review.
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found by citation matching
Combination L-T3 and L-T4 therapy for hypothyroidism.
Curr Opin Endocrinol Diabetes Obes. 2013.
PMID: 23974776
Review.
Do we need still more trials on T4 and T3 combination therapy in hypothyroidism?
Eur J Endocrinol. 2009.
PMID: 19808902
Search results
Page 1
T4 + T3 combination therapy: any progress?
Endocrine. 2019 Oct;66(1):70-78. doi: 10.1007/s12020-019-02052-2. Epub 2019 Oct 15.
Endocrine. 2019.
PMID: 31617166
Free PMC article.
Review.
Guidelines on T4 + T3 combination therapy were published in 2012. This review investigates whether the issue is better understood 7 years later. ...T4 monotherapy is associated with low serum T3 levels, which often require TSH-suppressive …
Guidelines on T4 + T3 combination therapy were published in 2012. This review investigates whether the issue is …
Combination L-T3 and L-T4 therapy for hypothyroidism.
Curr Opin Endocrinol Diabetes Obes. 2013 Oct;20(5):460-6. doi: 10.1097/01.med.0000432611.03732.49.
Curr Opin Endocrinol Diabetes Obes. 2013.
PMID: 23974776
Review.
PURPOSE OF REVIEW: Because of the longstanding controversy regarding whether hypothyroid patients can be optimally replaced by treatment with levothyroxine (L-T4) alone, numerous studies have addressed potential benefits of combined therapy of triiodot …
PURPOSE OF REVIEW: Because of the longstanding controversy regarding whether hypothyroid patients can be optimally replaced by treatm …
Treatment Preferences in Patients With Hypothyroidism.
J Clin Endocrinol Metab. 2025 Feb 18;110(3):887-900. doi: 10.1210/clinem/dgae651.
J Clin Endocrinol Metab. 2025.
PMID: 39290156
Free PMC article.
CONTEXT: Levothyroxine (L-T4) monotherapy is the standard of care for the treatment of hypothyroidism. A minority of L-T4-treated patients remain symptomatic and report better outcomes with combination therapy that contains liothyronine (L-T3 …
CONTEXT: Levothyroxine (L-T4) monotherapy is the standard of care for the treatment of hypothyroidism. A minority of L-T4 …
T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity.
Endocrinol Metab (Seoul). 2021 Oct;36(5):938-951. doi: 10.3803/EnM.2021.501. Epub 2021 Sep 30.
Endocrinol Metab (Seoul). 2021.
PMID: 34587734
Free PMC article.
Thyroxine (T4)+triiodothyronine (T3) combination therapy can be considered in case of persistent symptoms despite normal serum thyroid stimulating hormone in levothyroxine (LT4)-treated hypothyroid patients. ...This might be related to the 'hype …
Thyroxine (T4)+triiodothyronine (T3) combination therapy can be considered in case of persistent symptoms despit …
Combination treatment with T4 and T3: toward personalized replacement therapy in hypothyroidism?
J Clin Endocrinol Metab. 2012 Jul;97(7):2256-71. doi: 10.1210/jc.2011-3399. Epub 2012 May 16.
J Clin Endocrinol Metab. 2012.
PMID: 22593590
Review.
CONTEXT: Levothyroxine therapy is the traditional lifelong replacement therapy for hypothyroid patients. Over the last several years, new evidence has led clinicians to evaluate the option of combined T(3) and T(4) treatment to improve the quality of l …
CONTEXT: Levothyroxine therapy is the traditional lifelong replacement therapy for hypothyroid patients. Over the last …
LT4 and Slow Release T3 Combination: Optimum Therapy for Hypothyroidism?
Int J Endocrinol Metab. 2020 Apr 7;18(2):e100870. doi: 10.5812/ijem.100870. eCollection 2020 Apr.
Int J Endocrinol Metab. 2020.
PMID: 32636887
Free PMC article.
Review.
This article aimed to review current knowledge regarding LT4 monotherapy versus LT4+LT3 combination therapy and propose future directions regarding LT4+slow release T3 combination treatment for hypothyroidism. ...The LT4+LT3 combination …
This article aimed to review current knowledge regarding LT4 monotherapy versus LT4+LT3 combination therapy and propose future …
Combined T4 + T3 therapy versus T4 monotherapy effect on psychological health in hypothyroidism: A systematic review and meta-analysis.
Clin Endocrinol (Oxf). 2022 Jul;97(1):13-25. doi: 10.1111/cen.14742. Epub 2022 Apr 27.
Clin Endocrinol (Oxf). 2022.
PMID: 35445422
PURPOSE: To evaluate whether T4 + T3 combination therapy had advantages in improving psychological health compared with T4 monotherapy. ...Methodological heterogeneity had no influence on the results. The patients preferred combination …
PURPOSE: To evaluate whether T4 + T3 combination therapy had advantages in improving psychological health compar …
Evaluating the effectiveness of combined T4 and T3 therapy or desiccated thyroid versus T4 monotherapy in hypothyroidism: a systematic review and meta-analysis.
BMC Endocr Disord. 2024 Jun 14;24(1):90. doi: 10.1186/s12902-024-01612-6.
BMC Endocr Disord. 2024.
PMID: 38877429
Free PMC article.
We included two studies on desiccated thyroid and 15 studies on combined therapy. In this meta-analysis, combination therapy with T4 + T3 revealed significantly lower Free T4 levels (mean difference (MD): -0.34; 95% CI: -0.47, -0.2 …
We included two studies on desiccated thyroid and 15 studies on combined therapy. In this meta-analysis, combination …
THERAPY OF ENDOCRINE DISEASE: T4 + T3 combination therapy: is there a true effect?
Eur J Endocrinol. 2017 Dec;177(6):R287-R296. doi: 10.1530/EJE-17-0645. Epub 2017 Aug 30.
Eur J Endocrinol. 2017.
PMID: 28855267
Review.
It was hoped that T4 + T3 combination therapy might provide better outcomes, but that was not observed according to a meta-analysis of 11 randomized clinical trials comparing T4 monotherapy with T4 + T3 combination therap …
It was hoped that T4 + T3 combination therapy might provide better outcomes, but that was not observed according …
Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?
J Clin Endocrinol Metab. 2020 Sep 1;105(9):e3090-104. doi: 10.1210/clinem/dgaa430.
J Clin Endocrinol Metab. 2020.
PMID: 32614450
Free PMC article.
Review.
CONTEXT: It is well recognized that some hypothyroid patients on levothyroxine (LT4) remain symptomatic, but why patients are susceptible to this condition, why symptoms persist, and what is the role of combination therapy with LT4 and liothyronine (LT3), are …
CONTEXT: It is well recognized that some hypothyroid patients on levothyroxine (LT4) remain symptomatic, but why patients are suscept …
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