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Page 1
Connexin 36, a key element in pancreatic beta cell function.
Pérez-Armendariz EM. Pérez-Armendariz EM. Neuropharmacology. 2013 Dec;75:557-66. doi: 10.1016/j.neuropharm.2013.08.015. Epub 2013 Aug 23. Neuropharmacology. 2013. PMID: 23973309 Review.
They are excitable cells and most of them are electrically coupled through gap junction channels. Connexin 36 (Cx36) has been identified at junctional membranes of islet beta cells in both rodents and humans. ...This article is part of the Special Issu …
They are excitable cells and most of them are electrically coupled through gap junction channels. Connexin 36 (C …
Expression of connexin 36 in central nervous system and its role in epileptic seizure.
Peng YF, Wu JX, Yang H, Dong XQ, Zheng W, Song Z. Peng YF, et al. Chin Med J (Engl). 2012 Jul;125(13):2365-70. Chin Med J (Engl). 2012. PMID: 22882863 Review.
OBJECTIVE: This review discusses the experimental and clinical studies those show the expression of connexin 36 in the central nervous system and the possible role of connexin 36 in epileptic seizure. ...Connexin 36 is involved in some ne …
OBJECTIVE: This review discusses the experimental and clinical studies those show the expression of connexin 36 in the central …
Structural basis of connexin-36 gap junction channel inhibition.
Ding X, Aureli S, Vaithia A, Lavriha P, Schuster D, Khanppnavar B, Li X, Blum TB, Picotti P, Gervasio FL, Korkhov VM. Ding X, et al. Cell Discov. 2024 Jun 18;10(1):68. doi: 10.1038/s41421-024-00691-y. Cell Discov. 2024. PMID: 38890333 Free PMC article. No abstract available.
Connexin-36-positive gap junctions in ventral tegmental area GABA neurons sustain opiate dependence.
Maal-Bared G, Yee M, Harding EK, Ghebreselassie M, Bergamini M, Choy R, Kim E, Di Vito S, Patel M, Amirzadeh M, Grieder TE, Coles BL, Nagy JI, Bonin RP, Steenland HW, van der Kooy D. Maal-Bared G, et al. Eur J Neurosci. 2024 Jun;59(12):3422-3444. doi: 10.1111/ejn.16366. Epub 2024 Apr 28. Eur J Neurosci. 2024. PMID: 38679044
Here, we show that this switch in functional anatomy is contingent upon the gap junction-forming protein, connexin-36 (Cx36), in VTA GABA neurons. Intra-VTA infusions of the Cx36 blocker, mefloquine, in ODW rats resulted in a reversion to a drug …
Here, we show that this switch in functional anatomy is contingent upon the gap junction-forming protein, connexin …
Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1.
Li Q, Ma TL, Qiu YQ, Cui WQ, Chen T, Zhang WW, Wang J, Mao-Ying QL, Mi WL, Wang YQ, Chu YX. Li Q, et al. Neurosci Bull. 2020 Dec;36(12):1484-1499. doi: 10.1007/s12264-020-00594-4. Epub 2020 Oct 16. Neurosci Bull. 2020. PMID: 33067780 Free PMC article.
Here, we established a mouse model of partial transection of the infraorbital nerve (pT-ION) and found that the Connexin 36 (Cx36) inhibitor mefloquine caused greater alleviation of pT-ION-induced cold allodynia compared to the reduction of mechanical allodynia. ...
Here, we established a mouse model of partial transection of the infraorbital nerve (pT-ION) and found that the Connexin 36 (C …
Intralumenal docking of connexin 36 channels in the ER isolates mistrafficked protein.
Tetenborg S, Liss V, Breitsprecher L, Timonina K, Kotova A, Acevedo Harnecker AJ, Yuan C, Shihabeddin E, Ariakia F, Qin G, Chengzhi C, Dedek K, Zoidl G, Hensel M, O'Brien J. Tetenborg S, et al. J Biol Chem. 2023 Nov;299(11):105282. doi: 10.1016/j.jbc.2023.105282. Epub 2023 Sep 22. J Biol Chem. 2023. PMID: 37742923 Free PMC article.
The intracellular domains of connexins are essential for the assembly of gap junctions. For connexin 36 (Cx36), the major neuronal connexin, it has been shown that a dysfunctional PDZ-binding motif interferes with electrical synapse formation. ...Removing the …
The intracellular domains of connexins are essential for the assembly of gap junctions. For connexin 36 (Cx36), the maj …
Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction.
St Clair JR, Westacott MJ, Miranda J, Farnsworth NL, Kravets V, Schleicher WE, Dwulet JM, Levitt CH, Heintz A, Ludin NWF, Benninger RKP. St Clair JR, et al. J Physiol. 2023 Sep;601(18):4053-4072. doi: 10.1113/JP282114. Epub 2023 Aug 14. J Physiol. 2023. PMID: 37578890 Free PMC article.
Factors such as pro-inflammatory cytokines and free fatty acids disrupt gap junction coupling under in vitro conditions. Here we test whether gap junction coupling and coordinated [Ca(2+) ] dynamics are disrupted in T2D, and whether recovery of gap …
Factors such as pro-inflammatory cytokines and free fatty acids disrupt gap junction coupling under in vitro conditions. Here …
Connexin-36 distribution and layer-specific topography in the cat retina.
Telkes I, Kóbor P, Orbán J, Kovács-Öller T, Völgyi B, Buzás P. Telkes I, et al. Brain Struct Funct. 2019 Jul;224(6):2183-2197. doi: 10.1007/s00429-019-01876-y. Epub 2019 Jun 6. Brain Struct Funct. 2019. PMID: 31172263 Free PMC article.
Connexin-36 (Cx36) is the major constituent of mammalian retinal gap junctions positioned in key signal pathways. ...However, the high number of plaques per AII cell suggests that a considerable fraction of Cx36 gap junctions in the ON sublamina is for …
Connexin-36 (Cx36) is the major constituent of mammalian retinal gap junctions positioned in key signal pathways. ...Ho …
Connexin 36 Mediated Intercellular Endoplasmic Reticulum Stress Transmission Induces SSTA Resistance in Growth Hormone Pituitary Adenoma.
Wang Z, Lei Z, Wang Q, Jiang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T. Wang Z, et al. Int J Biol Sci. 2024 Jan 1;20(2):801-817. doi: 10.7150/ijbs.86736. eCollection 2024. Int J Biol Sci. 2024. PMID: 38169563 Free PMC article.
Moreover, SSTA stimulates inositol triphosphate (IP(3)) elevation, mediating ERS intercellular transfer. In addition, connexin 36 tunnels ERS transmission, and its blocker, Quinine, exhibits a synergistic effect with SSTA treating GH adenoma. ...
Moreover, SSTA stimulates inositol triphosphate (IP(3)) elevation, mediating ERS intercellular transfer. In addition, connexin 36 …
Endocytosis of Connexin 36 is Mediated by Interaction with Caveolin-1.
Kotova A, Timonina K, Zoidl GR. Kotova A, et al. Int J Mol Sci. 2020 Jul 29;21(15):5401. doi: 10.3390/ijms21155401. Int J Mol Sci. 2020. PMID: 32751343 Free PMC article.
The gap junctional protein connexin 36 (Cx36) has been co-purified with the lipid raft protein caveolin-1 (Cav-1). ...
The gap junctional protein connexin 36 (Cx36) has been co-purified with the lipid raft protein caveolin-1 …
547 results