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HLA-DRalpha1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis.
Meza-Romero R, Benedek G, Yu X, Mooney JL, Dahan R, Duvshani N, Bucala R, Offner H, Reiter Y, Burrows GG, Vandenbark AA. Meza-Romero R, et al. J Immunol. 2014 May 1;192(9):4164-73. doi: 10.4049/jimmunol.1303118. Epub 2014 Mar 28. J Immunol. 2014. PMID: 24683185 Free PMC article.
CD74, the cell-surface form of the MHC class II invariant chain, is a key inflammatory factor that is involved in various immune-mediated diseases as part of the macrophage migration inhibitory factor (MIF) binding complex. ...We found that DRalpha1 directly inhibit …
CD74, the cell-surface form of the MHC class II invariant chain, is a key inflammatory factor that is involved in various immune-medi …
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects.
Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows GG, Bourdette D, Offner H, Bucala R, Vandenbark AA. Benedek G, et al. Eur J Immunol. 2013 May;43(5):1309-21. doi: 10.1002/eji.201243162. Epub 2013 Apr 10. Eur J Immunol. 2013. PMID: 23576302 Free PMC article.
MIF and its receptor, CD74, are pivotal regulators of the immune system. Here, we demonstrate for the first time that partial MHC class II constructs comprised of linked beta1alpha1 domains with covalently attached antigenic peptides (also referred to as r …
MIF and its receptor, CD74, are pivotal regulators of the immune system. Here, we demonstrate for the first time that partial …
A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance.
Vandenbark AA, Meza-Romero R, Benedek G, Andrew S, Huan J, Chou YK, Buenafe AC, Dahan R, Reiter Y, Mooney JL, Offner H, Burrows GG. Vandenbark AA, et al. J Autoimmun. 2013 Feb;40:96-110. doi: 10.1016/j.jaut.2012.08.004. Epub 2012 Sep 29. J Autoimmun. 2013. PMID: 23026773 Free PMC article.
Binding of RTL constructs with CD74 involved a previously unrecognized MHC class II-alpha1/CD74 interaction that inhibited CD74 expression, blocked activity of its ligand, macrophage migration inhibitory factor, and reduced EAE severity. …
Binding of RTL constructs with CD74 involved a previously unrecognized MHC class II-alpha1/CD74 interaction that inhibi …
Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine.
Loftis JM, Ramani S, Firsick EJ, Hudson R, Le-Cook A, Murnane KS, Vandenbark A, Shirley RL. Loftis JM, et al. Front Psychiatry. 2023 Nov 9;14:1259041. doi: 10.3389/fpsyt.2023.1259041. eCollection 2023. Front Psychiatry. 2023. PMID: 38025429 Free PMC article.
We have shown that partial (p)MHC class II constructs (i.e., Recombinant T-cell receptor Ligand - RTL1000), comprised of the extracellular alpha1 and beta1 domains of MHC class II molecules linked covalently to myelin oligodendrocyte glycoprotein (MOG)-35-55 peptide …
We have shown that partial (p)MHC class II constructs (i.e., Recombinant T-cell receptor Ligand - RTL1000), comprised of the e …
DRα1-MOG-35-55 Reduces Permanent Ischemic Brain Injury.
Wang J, Ye Q, Xu J, Benedek G, Zhang H, Yang Y, Liu H, Meza-Romero R, Vandenbark AA, Offner H, Gao Y. Wang J, et al. Transl Stroke Res. 2017 Jun;8(3):284-293. doi: 10.1007/s12975-016-0514-2. Epub 2016 Dec 17. Transl Stroke Res. 2017. PMID: 27988839 Free PMC article.
The human leukocyte antigen-DRalpha1 domain linked to MOG-35-55 peptide (DRalpha1-MOG-35-55) is a partial major histocompatibility complex (MHC) class II construct which can inhibit neuroantigen-specific T cells and block binding of the cytokine/chemokine macrophage …
The human leukocyte antigen-DRalpha1 domain linked to MOG-35-55 peptide (DRalpha1-MOG-35-55) is a partial major histocompatibility complex ( …
A novel HLA-DRalpha1-MOG-35-55 construct treats experimental stroke.
Benedek G, Zhu W, Libal N, Casper A, Yu X, Meza-Romero R, Vandenbark AA, Alkayed NJ, Offner H. Benedek G, et al. Metab Brain Dis. 2014 Mar;29(1):37-45. doi: 10.1007/s11011-013-9440-0. Metab Brain Dis. 2014. PMID: 24122483 Free PMC article.
Furthermore, DRalpha1-MOG-35-55 bound to CD74 on monocytes and blocked both binding and downstream signaling of macrophage migration inhibition factor (MIF) that may play a key role in infarct development. The novel DRalpha1-MOG-35-55 construct is high …
Furthermore, DRalpha1-MOG-35-55 bound to CD74 on monocytes and blocked both binding and downstream signaling of macrophage mig …
The CD74 inhibitor DRhQ improves short-term memory and mitochondrial function in 5xFAD mouse model of Abeta accumulation.
Gladen-Kolarsky N, Neff CJ, Hack W, Brandes MS, Wiedrick J, Meza-Romero R, Lockwood DR, Quinn JF, Offner H, Vandenbark AA, Gray NE. Gladen-Kolarsky N, et al. Metab Brain Dis. 2025 Jan 14;40(1):95. doi: 10.1007/s11011-024-01433-5. Metab Brain Dis. 2025. PMID: 39808341
Evidence suggests that the inflammatory axis mediated by macrophage migration inhibitory factor (MIF) binding to its receptor, CD74, plays an important role in many central nervous system (CNS) disorders such as AD. Our group has developed DRhQ, a novel CD74 …
Evidence suggests that the inflammatory axis mediated by macrophage migration inhibitory factor (MIF) binding to its receptor, CD7 …