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Systems Genetics of Optic Nerve Axon Necrosis During Glaucoma.
Stiemke AB, Sah E, Simpson RN, Lu L, Williams RW, Jablonski MM. Stiemke AB, et al. Front Genet. 2020 Feb 27;11:31. doi: 10.3389/fgene.2020.00031. eCollection 2020. Front Genet. 2020. PMID: 32174956 Free PMC article.
Axon necrosis is not linked to locations of major known glaucoma genes in this family, including Gpnmb, Tyrp1, Cdh11, Pou6f2, and Cacna2d1. This indicates that although these genes contribute to pigmentary dispersion or elevated IOP, none directly modulates …
Axon necrosis is not linked to locations of major known glaucoma genes in this family, including Gpnmb, Tyrp1, Cdh11, Pou6f2, …
Contribution of nerve-axon reflex-related vasodilation to the total skin vasodilation in diabetic patients with and without neuropathy.
Hamdy O, Abou-Elenin K, LoGerfo FW, Horton ES, Veves A. Hamdy O, et al. Diabetes Care. 2001 Feb;24(2):344-9. doi: 10.2337/diacare.24.2.344. Diabetes Care. 2001. PMID: 11213890
OBJECTIVE: To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced vasodilation in the skin of normal and diabetic subjects. ...A significantly lower nonspecific nerve-axon-related vasod …
OBJECTIVE: To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced …
Exploring Optic Nerve Axon Regeneration.
Li HJ, Sun ZL, Yang XT, Zhu L, Feng DF. Li HJ, et al. Curr Neuropharmacol. 2017;15(6):861-873. doi: 10.2174/1570159X14666161227150250. Curr Neuropharmacol. 2017. PMID: 28029073 Free PMC article. Review.
However, the detailed molecular mechanisms underlying axon regeneration after optic nerve injury remain poorly understood. METHODS: Research content related to the detailed molecular mechanisms underlying axon regeneration after optic nerve inju …
However, the detailed molecular mechanisms underlying axon regeneration after optic nerve injury remain poorly understood. MET …
TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma.
McGrady NR, Risner ML, Vest V, Calkins DJ. McGrady NR, et al. Front Physiol. 2020 Mar 26;11:249. doi: 10.3389/fphys.2020.00249. eCollection 2020. Front Physiol. 2020. PMID: 32273850 Free PMC article.
The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca(2+), which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer's and Hunti …
The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by …
Microvascular changes in the diabetic foot.
Schramm JC, Dinh T, Veves A. Schramm JC, et al. Int J Low Extrem Wounds. 2006 Sep;5(3):149-59. doi: 10.1177/1534734606292281. Int J Low Extrem Wounds. 2006. PMID: 16928671 Review.
Impairment of the microcirculation of diabetic patients may contribute to secondary complications in the lower extremity, such as foot infections and ulcerations. ...Nerve-axon reflex related microvascular vasodilation is also impaired in the diabetic …
Impairment of the microcirculation of diabetic patients may contribute to secondary complications in the lower extremity, such as foo …
The Effects of Glaucoma on the Pressure-Induced Strain Response of the Human Lamina Cribrosa.
Midgett D, Liu B, Ling YTT, Jefferys JL, Quigley HA, Nguyen TD. Midgett D, et al. Invest Ophthalmol Vis Sci. 2020 Apr 9;61(4):41. doi: 10.1167/iovs.61.4.41. Invest Ophthalmol Vis Sci. 2020. PMID: 32343781 Free PMC article.
PURPOSE: To measure the ex vivo pressure-induced strain response of the human optic nerve head and analyze for variations with glaucoma diagnosis and optic nerve axon damage. ...CONCLUSIONS: The stiffness of the LC pressure-strain response was greater in diag …
PURPOSE: To measure the ex vivo pressure-induced strain response of the human optic nerve head and analyze for variations with glauco …
Overexpression of Foxc1 regenerates crushed rat facial nerves by promoting Schwann cells migration via the Wnt/β-catenin signaling pathway.
Xia W, Zhu J, Wang X, Tang Y, Zhou P, Wei X, Chang B, Zheng X, Zhu W, Hou M, Li S. Xia W, et al. J Cell Physiol. 2020 Dec;235(12):9609-9622. doi: 10.1002/jcp.29772. Epub 2020 May 11. J Cell Physiol. 2020. PMID: 32391604 Free PMC article.
Forkhead box C1 (Foxc1), a member of the forkhead transcription factor family, is implicated in cell migration. However, the role of Foxc1 in the progression after facial nerve crush remains unknown. ...After the transfection of Foxc1, the migration of SC was increa …
Forkhead box C1 (Foxc1), a member of the forkhead transcription factor family, is implicated in cell migration. However, the role of …
The anatomical and electrophysiological basis of peripheral nasal trigeminal chemoreception.
Silver WL, Finger TE. Silver WL, et al. Ann N Y Acad Sci. 2009 Jul;1170:202-5. doi: 10.1111/j.1749-6632.2009.03894.x. Ann N Y Acad Sci. 2009. PMID: 19686138
A subset of trigeminal nerve fibers, particularly those containing the neuropeptides substance P and calcitonin gene-related peptide (CGRP), responds to chemical irritants in the environment. ...A single ethmoid nerve axon may send branches to the nasa …
A subset of trigeminal nerve fibers, particularly those containing the neuropeptides substance P and calcitonin gene-related p …
S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction.
Montagna C, Di Giacomo G, Rizza S, Cardaci S, Ferraro E, Grumati P, De Zio D, Maiani E, Muscoli C, Lauro F, Ilari S, Bernardini S, Cannata S, Gargioli C, Ciriolo MR, Cecconi F, Bonaldo P, Filomeni G. Montagna C, et al. Antioxid Redox Signal. 2014 Aug 1;21(4):570-87. doi: 10.1089/ars.2013.5696. Epub 2014 May 13. Antioxid Redox Signal. 2014. PMID: 24684653 Free PMC article.
RESULTS: We demonstrate that, without any sign of protein nitration, young GSNOR-KO mice show neuromuscular atrophy due to loss of muscle mass, reduced fiber size, and neuropathic behavior. In particular, GSNOR-KO mice show a significant decrease in nerve axon numbe …
RESULTS: We demonstrate that, without any sign of protein nitration, young GSNOR-KO mice show neuromuscular atrophy due to loss of muscle ma …
Effects of substance P and calcitonin gene related peptide (CGRP) on guinea pig nasal mucosal secretion in vivo.
Gawin AZ, Baraniuk JN, Kaliner MA. Gawin AZ, et al. Acta Otolaryngol. 1993 Jul;113(4):533-9. doi: 10.3109/00016489309135859. Acta Otolaryngol. 1993. PMID: 7691022
Trigeminal sensory nerves contain and release the neurotransmitters substance P (SP) and calcitonin gene related peptide (CGRP) in nasal mucosa. The effects of SP and CGRP on nasal secretion were tested in an in vivo model of guinea pig nasal mucosal secretion by topically …
Trigeminal sensory nerves contain and release the neurotransmitters substance P (SP) and calcitonin gene related peptide (CGRP) in na …