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12,619 results

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Page 1
Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G.
Merleev A, Ji-Xu A, Toussi A, Tsoi LC, Le ST, Luxardi G, Xing X, Wasikowski R, Liakos W, Brüggen MC, Elder JT, Adamopoulos IE, Izumiya Y, Leal AR, Li Q, Kuzminykh NY, Kirane A, Marusina AI, Gudjonsson JE, Maverakis E. Merleev A, et al. JCI Insight. 2022 Aug 22;7(16):e141193. doi: 10.1172/jci.insight.141193. JCI Insight. 2022. PMID: 35862195 Free PMC article.
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the LDL receptor (LDLR). ...
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the LDL receptor (LDLR). ...
Mouse Models of Human Proprotein Convertase Insufficiency.
Shakya M, Lindberg I. Shakya M, et al. Endocr Rev. 2021 May 25;42(3):259-294. doi: 10.1210/endrev/bnaa033. Endocr Rev. 2021. PMID: 33382413 Free PMC article. Review.
In this review, we present a general introduction to proprotein convertase structure and biochemistry, followed by a comprehensive discussion of each member of the kexin-like subfamily of proprotein convertases. ...The creation of more sophisticated mouse models wit …
In this review, we present a general introduction to proprotein convertase structure and biochemistry, followed by a comprehensive di …
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.
Abifadel M, Varret M, Rabès JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, Derré A, Villéger L, Farnier M, Beucler I, Bruckert E, Chambaz J, Chanu B, Lecerf JM, Luc G, Moulin P, Weissenbach J, Prat A, Krempf M, Junien C, Seidah NG, Boileau C. Abifadel M, et al. Nat Genet. 2003 Jun;34(2):154-6. doi: 10.1038/ng1161. Nat Genet. 2003. PMID: 12730697
We mapped a third locus associated with ADH, HCHOLA3 at 1p32, and now report two mutations in the gene PCSK9 (encoding proprotein convertase subtilisin/kexin type 9) that cause ADH. PCSK9 encodes NARC-1 (neural apoptosis regulated convertase), a newly identified hum …
We mapped a third locus associated with ADH, HCHOLA3 at 1p32, and now report two mutations in the gene PCSK9 (encoding proprotein convert …
The proprotein convertase furin in tumour progression.
Jaaks P, Bernasconi M. Jaaks P, et al. Int J Cancer. 2017 Aug 15;141(4):654-663. doi: 10.1002/ijc.30714. Epub 2017 May 15. Int J Cancer. 2017. PMID: 28369813 Review.
Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. ...Hence, this review will focus on the proprotein convertase furin and its role in cancer. The expression of furin has been confirmed in a large spectrum …
Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. ...Hence, this review …
Proprotein convertase subtilisin/kexin 9 inhibitors: an emerging lipid-lowering therapy?
Dragan S, Serban MC, Banach M. Dragan S, et al. J Cardiovasc Pharmacol Ther. 2015 Mar;20(2):157-68. doi: 10.1177/1074248414539562. Epub 2014 Jun 17. J Cardiovasc Pharmacol Ther. 2015. PMID: 24938457 Review.
Proprotein convertase subtilisin/kexin 9 (PCSK9) is part of the proteinase K subfamily of subtilases and plays a key role in lipid metabolism. ...
Proprotein convertase subtilisin/kexin 9 (PCSK9) is part of the proteinase K subfamily of subtilases and plays a key role in lipid me …
Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors.
Klaushofer R, Bloch K, Eder LS, Marzaro S, Schubert M, Böttcher-Friebertshäuser E, Brandstetter H, Dahms SO. Klaushofer R, et al. Nat Commun. 2025 Sep 2;16(1):8206. doi: 10.1038/s41467-025-63479-y. Nat Commun. 2025. PMID: 40897699 Free PMC article.
Proprotein convertases (PCs), including furin and PC1/3 among nine mammalian homologues, mediate the maturation of numerous secreted substrates by proteolytic cleavage. ...
Proprotein convertases (PCs), including furin and PC1/3 among nine mammalian homologues, mediate the maturation of numerous secreted …
PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future.
Shimada YJ, Cannon CP. Shimada YJ, et al. Eur Heart J. 2015 Sep 21;36(36):2415-24. doi: 10.1093/eurheartj/ehv174. Epub 2015 May 12. Eur Heart J. 2015. PMID: 25971287 Review.
However, there are several patient populations that warrant further decrease in LDL-C by additional cholesterol-lowering therapy other than statins. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are a new class of drugs that have been shown to further de …
However, there are several patient populations that warrant further decrease in LDL-C by additional cholesterol-lowering therapy other than …
Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.
Gyamera-Acheampong C, Mbikay M. Gyamera-Acheampong C, et al. Hum Reprod Update. 2009 Mar-Apr;15(2):237-47. doi: 10.1093/humupd/dmn060. Epub 2008 Dec 24. Hum Reprod Update. 2009. PMID: 19109312 Review.
BACKGROUND: Proprotein convertase subtilisin/kexin type 4 (PCSK4), also known as proprotein convertase 4, belongs to a family of endoproteinases involved in the proteolytic conversion of secretory precursor proteins to their active forms. ...
BACKGROUND: Proprotein convertase subtilisin/kexin type 4 (PCSK4), also known as proprotein convertase 4, belongs to a family …
Proprotein convertase subtilisin kexin9 (PCSK9): a novel target for cholesterol regulation.
Basak A, Palmer-Smith H, Mishra P. Basak A, et al. Protein Pept Lett. 2012 Jun 1;19(6):575-85. doi: 10.2174/092986612800494020. Protein Pept Lett. 2012. PMID: 22519528 Review.
Proprotein Convertase Subtilisin Kexin9 (PCSK9), originally called Neural Apoptosis-Regulated Convertase1 (NARC1), is the latest member of mammalian subtilase super-family. ...
Proprotein Convertase Subtilisin Kexin9 (PCSK9), originally called Neural Apoptosis-Regulated Convertase1 (NARC1), is the latest memb …
Terminal complement without C5 convertase?
Roumenina LT. Roumenina LT. Blood. 2021 Jan 28;137(4):431-432. doi: 10.1182/blood.2020010133. Blood. 2021. PMID: 33507301 Free article. No abstract available.
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