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Novel microbiome-based therapeutics for chronic rhinosinusitis.
Cope EK, Lynch SV. Cope EK, et al. Curr Allergy Asthma Rep. 2015 Mar;15(3):504. doi: 10.1007/s11882-014-0504-y. Curr Allergy Asthma Rep. 2015. PMID: 25777787
Resident microbiota interact extensively with immune cells and epithelia at mucosal surfaces including the airways, and chronic inflammatory and allergic respiratory disorders are associated with dysbiosis of the airway microbiome. Chronic rhinosinusitis (CRS …
Resident microbiota interact extensively with immune cells and epithelia at mucosal surfaces including the airways, and chronic infla …
A chronic rhinosinusitis-derived isolate of Pseudomonas aeruginosa induces acute and pervasive effects on the murine upper airway microbiome and host immune response.
Cope EK, Goldberg AN, Pletcher SD, Lynch SV. Cope EK, et al. Int Forum Allergy Rhinol. 2016 Dec;6(12):1229-1237. doi: 10.1002/alr.21819. Epub 2016 Sep 6. Int Forum Allergy Rhinol. 2016. PMID: 27598436
However, little is known of the dynamics of upper airway infection and the role of the sinus mucosal microbiome in short- and longer-term outcomes using clinical isolates from patients with chronic rhinosinusitis. METHODS: We examine microbiome and immune dynamics a …
However, little is known of the dynamics of upper airway infection and the role of the sinus mucosal microbiome in short- and longer-term ou …
Heterogeneity of Microbiota Dysbiosis in Chronic Rhinosinusitis: Potential Clinical Implications and Microbial Community Mechanisms Contributing to Sinonasal Inflammation.
Lee K, Pletcher SD, Lynch SV, Goldberg AN, Cope EK. Lee K, et al. Front Cell Infect Microbiol. 2018 May 23;8:168. doi: 10.3389/fcimb.2018.00168. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 29876323 Free PMC article.
These microbes contribute to the development and function of physiologic and immunological features that are key to host health status. Not surprisingly, several chronic inflammatory diseases have been attributed to dysbiosis of microbiota composition or function, includin …
These microbes contribute to the development and function of physiologic and immunological features that are key to host health status. Not …
Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences.
Cope EK, Goldberg AN, Pletcher SD, Lynch SV. Cope EK, et al. Microbiome. 2017 May 12;5(1):53. doi: 10.1186/s40168-017-0266-6. Microbiome. 2017. PMID: 28494786 Free PMC article.
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by persistent sinonasal inflammation and sinus microbiome dysbiosis. ...
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by persistent sinonasal inflammation and sin …