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Page 1
The potential of GHK as an anti-aging peptide.
Dou Y, Lee A, Zhu L, Morton J, Ladiges W. Dou Y, et al. Aging Pathobiol Ther. 2020 Mar 27;2(1):58-61. doi: 10.31491/apt.2020.03.014. Aging Pathobiol Ther. 2020. PMID: 35083444 Free PMC article.
The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have anti-inflammatory and tissue remodeling properties. GHK-Cu has been shown to promote skin remodeling, wound hea …
The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II …
Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate.
Bossak-Ahmad K, Wiśniewska MD, Bal W, Drew SC, Frączyk T. Bossak-Ahmad K, et al. Int J Mol Sci. 2020 Aug 27;21(17):6190. doi: 10.3390/ijms21176190. Int J Mol Sci. 2020. PMID: 32867146 Free PMC article.
Regarding the natural concentrations of the studied molecules in some human tissues, together with the affinities reported here, we conclude that the ternary complex [GHK][Cu(II)][cis-urocanic acid] may be partly responsible for biological effects of GHK and urocani …
Regarding the natural concentrations of the studied molecules in some human tissues, together with the affinities reported here, we conclude …
Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.
Dymek M, Olechowska K, Hąc-Wydro K, Sikora E. Dymek M, et al. Pharmaceutics. 2023 Oct 18;15(10):2485. doi: 10.3390/pharmaceutics15102485. Pharmaceutics. 2023. PMID: 37896245 Free PMC article.
They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding peptide, GHK-Cu (glycyl-L-histidyl-L-lysine). Anionic (AL) and cationic (CL) hydrogenated lecithin-based liposomes were …
They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding …
Theoretical study of copper binding to GHK peptide.
Alshammari N, Platts JA. Alshammari N, et al. Comput Biol Chem. 2020 Jun;86:107265. doi: 10.1016/j.compbiolchem.2020.107265. Epub 2020 Apr 22. Comput Biol Chem. 2020. PMID: 32371360
Conventional molecular dynamics simulation of Cu-GHK shows the stability of the copper-peptide binding over 100 ps trajectory. Four equatorial bonds in 3N1O coordination remain stable throughout simulation, while a fifth in apical position from C-terminal carboxylat …
Conventional molecular dynamics simulation of Cu-GHK shows the stability of the copper-peptide binding over 100 ps trajectory. …
The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.
Park JR, Lee H, Kim SI, Yang SR. Park JR, et al. Oncotarget. 2016 Sep 6;7(36):58405-58417. doi: 10.18632/oncotarget.11168. Oncotarget. 2016. PMID: 27517151 Free PMC article.
The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remodeling. ...Therefore, we examined the effects of GHK-Cu in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in vitro and …
The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remod …
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
Pickart L, Vasquez-Soltero JM, Margolina A. Pickart L, et al. Biomed Res Int. 2015;2015:648108. doi: 10.1155/2015/648108. Epub 2015 Jul 7. Biomed Res Int. 2015. PMID: 26236730 Free PMC article. Review.
It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity of both metalloproteinases and their inhibitors. ...
It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both sy …
The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.
Pickart L, Vasquez-Soltero JM, Margolina A. Pickart L, et al. Oxid Med Cell Longev. 2012;2012:324832. doi: 10.1155/2012/324832. Epub 2012 May 10. Oxid Med Cell Longev. 2012. PMID: 22666519 Free PMC article. Review.
Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions. ...The human tripeptide GHK was discovered in 19 …
Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are consider …
Ultrasensitive and Label-Free Detection of Copper Ions by GHK-Modified Asymmetric Nanochannels.
An P, Zhang Z, Yang J, Wang T, Wang Z, Sun CL, Qin C, Li J. An P, et al. Anal Chem. 2023 Sep 12;95(36):13456-13462. doi: 10.1021/acs.analchem.3c01174. Epub 2023 Aug 25. Anal Chem. 2023. PMID: 37624577
Due to the robust complexing ability between Cu(2+) and GHK peptide, the GHK-modified asymmetric nanochannels can form GHK-Cu complexes on the inner surface of nanochannels when Cu(2+) passes through the nanochannels. ...The GHK-Cu complexes cou …
Due to the robust complexing ability between Cu(2+) and GHK peptide, the GHK-modified asymmetric nanochannels can form GHK- …
Tripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction.
Fu SC, Cheuk YC, Chiu WY, Yung SH, Rolf CG, Chan KM. Fu SC, et al. J Orthop Res. 2015 Jul;33(7):1024-33. doi: 10.1002/jor.22831. Epub 2015 Apr 10. J Orthop Res. 2015. PMID: 25731775 Free article.
After anterior cruciate ligament reconstruction (ACLR), the biological healing of the graft is a rate-limiting step which can contribute to graft failure. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(II) (GHK-Cu) is a well-known activator of ti …
After anterior cruciate ligament reconstruction (ACLR), the biological healing of the graft is a rate-limiting step which can contribute to …
The human tri-peptide GHK and tissue remodeling.
Pickart L. Pickart L. J Biomater Sci Polym Ed. 2008;19(8):969-88. doi: 10.1163/156856208784909435. J Biomater Sci Polym Ed. 2008. PMID: 18644225 Review.
Tissue remodeling follows the initial phase of wound healing and stops inflammatory and scar-forming processes, then restores the normal tissue morphology. The human peptide Gly-(L-His)-(L-Lys) or GHK, has a copper 2+ (Cu(2+)) affinity similar to the copper t …
Tissue remodeling follows the initial phase of wound healing and stops inflammatory and scar-forming processes, then restores the normal tis …
81 results