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Year Number of Results
2004 1
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30 results

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Page 1
Basic and Translational Models of Cooperative Oncogenesis.
Richardson HE, Cordero JB, Grifoni D. Richardson HE, et al. Among authors: cordero jb. Int J Mol Sci. 2020 Aug 18;21(16):5919. doi: 10.3390/ijms21165919. Int J Mol Sci. 2020. PMID: 32824656 Free PMC article. No abstract available.
Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila.
Medina AB, Perochon J, Tian Y, Johnson CT, Holcombe J, Ramesh P, Polcowñuk S, Yu Y, Cordero JB. Medina AB, et al. Among authors: cordero jb. Dev Cell. 2025 Nov 17;60(22):3085-3101.e6. doi: 10.1016/j.devcel.2025.06.036. Epub 2025 Jul 21. Dev Cell. 2025. PMID: 40695286 Free article.
Here, we identify signaling between enteroendocrine (EE) cells, vasculature-like trachea, and neurons, which drives regional and global stem cell proliferation during adult intestinal regeneration in Drosophila. Reactive oxygen species (ROS) from midgut cells promote produ …
Here, we identify signaling between enteroendocrine (EE) cells, vasculature-like trachea, and neurons, which drives regional and global stem …
Investigating local and systemic intestinal signalling in health and disease with Drosophila.
Medina A, Bellec K, Polcowñuk S, Cordero JB. Medina A, et al. Among authors: cordero jb. Dis Model Mech. 2022 Mar 1;15(3):dmm049332. doi: 10.1242/dmm.049332. Epub 2022 Mar 28. Dis Model Mech. 2022. PMID: 35344037 Free PMC article. Review.
In this Review, we highlight Drosophila research that has contributed to our understanding of how the adult intestine interacts with its microenvironment and with distant organs. We discuss the implications of these findings for understanding intestinal and whole-body path …
In this Review, we highlight Drosophila research that has contributed to our understanding of how the adult intestine interacts with …
Intestinal Stem Cells: Got Calcium?
Nászai M, Cordero JB. Nászai M, et al. Among authors: cordero jb. Curr Biol. 2016 Feb 8;26(3):R117-9. doi: 10.1016/j.cub.2015.12.012. Curr Biol. 2016. PMID: 26859268 Free article.
A new study identifies local cytoplasmic calcium as a central integrator of metabolic and proliferative signals in Drosophila intestinal stem cells....
A new study identifies local cytoplasmic calcium as a central integrator of metabolic and proliferative signals in Drosophila intesti …
c-Src drives intestinal regeneration and transformation.
Cordero JB, Ridgway RA, Valeri N, Nixon C, Frame MC, Muller WJ, Vidal M, Sansom OJ. Cordero JB, et al. EMBO J. 2014 Jul 1;33(13):1474-91. doi: 10.1002/embj.201387454. Epub 2014 Apr 30. EMBO J. 2014. PMID: 24788409 Free PMC article.
There has been much speculation about the functional role of Src in colorectal cancer (CRC), with Src amplification and potential activating mutations in up to 20% of the human tumours, although this has never been addressed due to multiple redundant family members. Here, we have …
There has been much speculation about the functional role of Src in colorectal cancer (CRC), with Src amplification and potential activating …
Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut.
Nászai M, Carroll LR, Cordero JB. Nászai M, et al. Among authors: cordero jb. Insect Biochem Mol Biol. 2015 Dec;67:9-14. doi: 10.1016/j.ibmb.2015.05.016. Epub 2015 May 27. Insect Biochem Mol Biol. 2015. PMID: 26024801 Free article. Review.
The discovery of the presence of stem cells in the adult midgut of the fruit fly Drosophila melanogaster has significantly impacted our understanding of the role of stem cells in intestinal homeostasis. Here we will review the current knowledge of the main mechanisms invol …
The discovery of the presence of stem cells in the adult midgut of the fruit fly Drosophila melanogaster has significantly impacted o …
Drosophila as a Model System to Study Nonautonomous Mechanisms Affecting Tumour Growth and Cell Death.
Parvy JP, Hodgson JA, Cordero JB. Parvy JP, et al. Among authors: cordero jb. Biomed Res Int. 2018 Mar 13;2018:7152962. doi: 10.1155/2018/7152962. eCollection 2018. Biomed Res Int. 2018. PMID: 29725601 Free PMC article. Review.
This is necessary in order to achieve a comprehensive understanding into the mechanisms driving disease initiation and progression, to aid the development of appropriate therapies. In recent decades, the fruit fly Drosophila melanogaster and its associated powerful genetic …
This is necessary in order to achieve a comprehensive understanding into the mechanisms driving disease initiation and progression, to aid t …
Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies.
Perochon J, Carroll LR, Cordero JB. Perochon J, et al. Among authors: cordero jb. Genes (Basel). 2018 Mar 2;9(3):138. doi: 10.3390/genes9030138. Genes (Basel). 2018. PMID: 29498662 Free PMC article. Review.
Here, we summarize the latest knowledge acquired from mouse and Drosophila research regarding canonical Wnt signalling and its key functions during stem cell driven intestinal homeostasis, regeneration, ageing and cancer....
Here, we summarize the latest knowledge acquired from mouse and Drosophila research regarding canonical Wnt signalling and its key fu …
RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.
Nászai M, Bellec K, Yu Y, Román-Fernández A, Sandilands E, Johansson J, Campbell AD, Norman JC, Sansom OJ, Bryant DM, Cordero JB. Nászai M, et al. Among authors: cordero jb. Elife. 2021 Jun 7;10:e63807. doi: 10.7554/eLife.63807. Elife. 2021. PMID: 34096503 Free PMC article.
Here, we show that RAL GTPases are necessary and sufficient to activate EGFR/MAPK signalling in the intestine, via induction of EGFR internalisation. Knocking down Drosophila RalA from intestinal stem and progenitor cells leads to increased levels of plasma membrane-associ …
Here, we show that RAL GTPases are necessary and sufficient to activate EGFR/MAPK signalling in the intestine, via induction of EGFR interna …
Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia.
Cordero JB, Sansom OJ. Cordero JB, et al. Acta Physiol (Oxf). 2012 Jan;204(1):137-43. doi: 10.1111/j.1748-1716.2011.02288.x. Epub 2011 Apr 22. Acta Physiol (Oxf). 2012. PMID: 21439026 Review.
Since the discovery of stem cell markers in the mammalian intestine - such as Lgr5 - and the presence of Drosophila intestinal stem cells there have been field-changing discoveries that have revolutionized our understanding of intestinal homeostasis, stem cells and transfo …
Since the discovery of stem cell markers in the mammalian intestine - such as Lgr5 - and the presence of Drosophila intestinal stem c …
30 results