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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1950 1
1951 6
1952 3
1953 1
1954 1
1955 3
1956 6
1957 6
1958 5
1959 6
1960 5
1961 4
1962 7
1963 6
1964 14
1965 24
1966 18
1967 18
1968 11
1969 16
1970 22
1971 19
1972 31
1973 23
1974 26
1975 66
1976 80
1977 75
1978 92
1979 80
1980 106
1981 156
1982 117
1983 112
1984 156
1985 124
1986 126
1987 218
1988 129
1989 163
1990 253
1991 179
1992 159
1993 229
1994 161
1995 252
1996 149
1997 167
1998 227
1999 144
2000 151
2001 229
2002 134
2003 637
2004 798
2005 764
2006 752
2007 576
2008 516
2009 463
2010 445
2011 437
2012 482
2013 659
2014 825
2015 907
2016 900
2017 816
2018 793
2019 739
2020 416
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15,375 results
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Page 1
Host Factors in Coronavirus Replication.
de Wilde AH, et al. Curr Top Microbiol Immunol 2018 - Review. PMID 28643204
Despite the economic and societal impact of such coronavirus infections, and the likelihood of future outbreaks of additional pathogenic coronaviruses, our options to prevent or treat coronavirus infections remain very limited. ...Next to a role in basic virus replication or virus assembly, many of the coronavirus proteins expressed in the infected cell contribute to the coronavirus-host interplay. ...
Despite the economic and societal impact of such coronavirus infections, and the likelihood of future outbreaks of additional pathoge …
Coronavirus envelope protein: current knowledge.
Schoeman D and Fielding BC. Virol J 2019 - Review. PMID 31133031 Free PMC article.
BACKGROUND: Coronaviruses (CoVs) primarily cause enzootic infections in birds and mammals but, in the last few decades, have shown to be capable of infecting humans as well. ...
BACKGROUND: Coronaviruses (CoVs) primarily cause enzootic infections in birds and mammals but, in the last few decades, have shown to …
Lysosomal Proteases Are a Determinant of Coronavirus Tropism.
Zheng Y, et al. J Virol 2018. PMID 30258004 Free PMC article.
Despite the importance of lysosomal proteases in both coronavirus entry and cell metabolism, the correlation between lysosomal proteases and cell tropism of coronaviruses has not been established. Here, we examined the roles of lysosomal proteases in activating coronavirus surface spike proteins for membrane fusion, using the spike proteins from severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) as the model system. ...
Despite the importance of lysosomal proteases in both coronavirus entry and cell metabolism, the correlation between lysosomal protea …
The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.
Báez-Santos YM, et al. Antiviral Res 2015 - Review. PMID 25554382 Free PMC article.
The recent emergence of the deadly human coronavirus that causes Middle East respiratory syndrome (MERS-CoV) is a sobering reminder that new and deadly coronaviruses can emerge at any time with the potential to become pandemics. Therefore, the continued development of therapeutic and prophylactic countermeasures to potentially deadly coronaviruses is warranted. ...
The recent emergence of the deadly human coronavirus that causes Middle East respiratory syndrome (MERS-CoV) is a sobering reminder t …
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.
Agostini ML, et al. mBio 2018. PMID 29511076 Free PMC article.
We recently reported that the nucleoside analogue GS-5734 (remdesivir) potently inhibits human and zoonotic CoVs in vitro and in a severe acute respiratory syndrome coronavirus (SARS-CoV) mouse model. ...Here, we show that GS-5734 inhibits murine hepatitis virus (MHV) with similar 50% effective concentration values (EC(50)) as SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). ...
We recently reported that the nucleoside analogue GS-5734 (remdesivir) potently inhibits human and zoonotic CoVs in vitro and in a severe ac …
Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats.
Hu D, et al. Emerg Microbes Infect 2018. PMID 30209269 Free PMC article.
SARS coronavirus (SARS-CoV), the causative agent of the large SARS outbreak in 2003, originated in bats. Many SARS-like coronaviruses (SL-CoVs) have been detected in bats, particularly those that reside in China, Europe, and Africa. ...PCR amplification of the conserved coronaviral protein RdRp detected coronaviruses in 26.65% of bats belonging to this region, and this number was influenced by seasonal changes. ...
SARS coronavirus (SARS-CoV), the causative agent of the large SARS outbreak in 2003, originated in bats. Many SARS-like coronaviru
Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.
Zaki AM, et al. N Engl J Med 2012. PMID 23075143 Free article.
A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. ...The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. ...
A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent …
Human coronavirus circulation in the United States 2014-2017.
Killerby ME, et al. J Clin Virol 2018. PMID 29427907
BACKGROUND: Human coronaviruses (HCoVs) -OC43, -229E, -NL63 and -HKU1 cause upper and lower respiratory tract infections. HCoVs are globally distributed and the predominant species may vary by region or year. ...
BACKGROUND: Human coronaviruses (HCoVs) -OC43, -229E, -NL63 and -HKU1 cause upper and lower respiratory tract infections. HCoVs are g …
Structural insights into coronavirus entry.
Tortorici MA and Veesler D. Adv Virus Res 2019. PMID 31522710
Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). ...Here, we review our understanding of the infection mechanism used by coronaviruses derived from recent structural and biochemical studies....
Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute re
Origin and evolution of pathogenic coronaviruses.
Cui J, et al. Nat Rev Microbiol 2019 - Review. PMID 30531947
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. ...In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses, as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs....
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two h …
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