Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2.
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Møhlenberg M, et al.
Proc Natl Acad Sci U S A. 2026 Mar 24;123(12):e2522111123. doi: 10.1073/pnas.2522111123. Epub 2026 Mar 16.
Proc Natl Acad Sci U S A. 2026.
PMID: 41838921
The clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection ranges from asymptomatic cases to critical COVID-19 pneumonia. ...We demonstrate that human pulmonary A549- …
The clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV- …