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Comprehensive In Silico Analysis of Uncaria Tomentosa Extract: Chemical Profiling, Antioxidant Assessment, and CLASP Protein Interaction for Drug Design in Neurodegenerative Diseases.
Kumar S, Panda SP. Kumar S, et al. Curr Comput Aided Drug Des. 2024 Jan 2. doi: 10.2174/0115734099284849231212095407. Online ahead of print. Curr Comput Aided Drug Des. 2024. PMID: 38310572
Interactions between conventional quinovic acid, chlorogenic acid, epicatechin, corynoxeine, rhynchophylline and syringic acid and CLASP were studied through in silico molecular docking using Auto Dock 4.2. ...
Interactions between conventional quinovic acid, chlorogenic acid, epicatechin, corynoxeine, rhynchophylline and syringic acid and CL …
Anti-Shigella and antioxidant-based screening of some Cameroonian medicinal plants, UHPLC-LIT-MS/MS fingerprints, and prediction of pharmacokinetic and drug-likeness properties of identified chemicals.
Melogmo Dongmo YK, Tchatat Tali MB, Dize D, Jiatsa Mbouna CD, Kache Fotsing S, Ngouana V, Pinlap BR, Zeuko'o Menkem E, Yamthe Tchokouaha LR, Fotso Wabo G, Lenta Ndjakou B, Lunga PK, Fekam Boyom F. Melogmo Dongmo YK, et al. J Ethnopharmacol. 2024 Apr 24;324:117788. doi: 10.1016/j.jep.2024.117788. Epub 2024 Jan 29. J Ethnopharmacol. 2024. PMID: 38296176
Pharmacokinetic prediction of these chemicals showed that compound 6 (4,6a-bis(Hydroxymethyl)-9a-methyl-3-oxo-1a,1b,3,5,6,6a,7a,9a-octahydrobis (oxireno)[2',3':5,6; 2",3'':9,10]cyclodeca[1,2-b]furan-5-yl methacrylate), compound 8 (Corynoxeine), and compounds 35 (Stachybotr …
Pharmacokinetic prediction of these chemicals showed that compound 6 (4,6a-bis(Hydroxymethyl)-9a-methyl-3-oxo-1a,1b,3,5,6,6a,7a,9a-octahydro …
Development of a novel UHPLC-MS/MS method for the quantification of corynoxeine: Application to pharmacokinetics and tissue distribution studies in normal and chronic unpredictable mild stress-induced depression rats.
Sun Q, Zhao N, Zhang TJ, Wang SY, Wang L, Meng FH. Sun Q, et al. J Pharm Biomed Anal. 2024 Jan 20;238:115850. doi: 10.1016/j.jpba.2023.115850. Epub 2023 Nov 7. J Pharm Biomed Anal. 2024. PMID: 37948778
Corynoxeine, a natural active alkaloid found in Genus Uncaria, has been reported to have anti-depressant effects. ...The pharmacokinetics and tissue distribution profiles of corynoxeine were altered in CUMS-induced depression rats compared to normal rats and these e …
Corynoxeine, a natural active alkaloid found in Genus Uncaria, has been reported to have anti-depressant effects. ...The pharmacokine …
Supercritical fluid chromatography based on reversed-phase/ ion chromatography mixed-mode stationary phase for separation of spirooxindole alkaloids.
Fu Q, Dong W, Ge D, Ke Y, Jin Y. Fu Q, et al. J Chromatogr A. 2023 Aug 30;1705:464163. doi: 10.1016/j.chroma.2023.464163. Epub 2023 Jun 16. J Chromatogr A. 2023. PMID: 37348226
., C8SAX with EtOH+ 10 mM acidic ammonium formate in CO(2), or C8SCX with EtOH+0.1% diethylamine in CO(2), the baseline separation of corynoxeine and isocorynoxeine, rhynchophylline and isorhynchophylline was achieved within 5 min....
., C8SAX with EtOH+ 10 mM acidic ammonium formate in CO(2), or C8SCX with EtOH+0.1% diethylamine in CO(2), the baseline separation of cor …
Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla.
Zhou HF, Li WY, Wu Q, Ren J, Peng LY, Li XN, Zhao QS. Zhou HF, et al. Org Lett. 2023 Jun 23;25(24):4434-4438. doi: 10.1021/acs.orglett.3c01342. Epub 2023 Jun 8. Org Lett. 2023. PMID: 37288843
Based on the biomimetic semisynthesis strategy, compounds 1-8 were synthesized in three steps via the key reactions of 1,3-dipolar cycloaddition and Krapcho decarboxylation from corynoxeine. Interestingly, compound 3 showed moderate inhibitory activity against the K(v)1.5 …
Based on the biomimetic semisynthesis strategy, compounds 1-8 were synthesized in three steps via the key reactions of 1,3-dipolar cycloaddi …
Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold.
Nguyen TM, Grzech D, Chung K, Xia Z, Nguyen TD, Dang TT. Nguyen TM, et al. Front Plant Sci. 2023 Feb 3;14:1125158. doi: 10.3389/fpls.2023.1125158. eCollection 2023. Front Plant Sci. 2023. PMID: 36818833 Free PMC article.
Herein, we report the discovery and characterization of a cytochrome P450 enzyme from kratom (Mitragyna speciosa) responsible for the formation of the spirooxindole alkaloids 3-epi-corynoxeine (3R, 7R) and isocorynoxeine (3S, 7S) from the corynanthe-type (3R)-secoyohimbane …
Herein, we report the discovery and characterization of a cytochrome P450 enzyme from kratom (Mitragyna speciosa) responsible for the format …
Identification of PXR Activators from Uncaria Rhynchophylla (Gou Teng) and Uncaria Tomentosa (Cat's Claw).
Lei S, Lu J, Cheng A, Hussain Z, Tidgewell K, Zhu J, Ma X. Lei S, et al. Drug Metab Dispos. 2023 May;51(5):629-636. doi: 10.1124/dmd.122.001234. Epub 2023 Feb 16. Drug Metab Dispos. 2023. PMID: 36797057
Four compounds, isocorynoxeine, rhynchophylline, isorhynchophylline, and corynoxeine, were identified as PXR activators from both Gou Teng and cat's claw extracts. ...
Four compounds, isocorynoxeine, rhynchophylline, isorhynchophylline, and corynoxeine, were identified as PXR activators from both Gou …
Gene coexpression networks allow the discovery of two strictosidine synthases underlying monoterpene indole alkaloid biosynthesis in Uncaria rhynchophylla.
Jiang CX, Yu JX, Fei X, Pan XJ, Zhu NN, Lin CL, Zhou D, Zhu HR, Qi Y, Wu ZG. Jiang CX, et al. Int J Biol Macromol. 2023 Jan 31;226:1360-1373. doi: 10.1016/j.ijbiomac.2022.11.249. Epub 2022 Nov 26. Int J Biol Macromol. 2023. PMID: 36442554
Further, overexpression of UrSTR1/5 in UR hairy roots constitutively increased the biosynthesis of bioactive UR-MIAs (rhynchophylline, isorhynchophylline, corynoxeine, etc), whereas RNAi of UrSTR1/5 significantly decreased UR-MIA biosynthesis. ...
Further, overexpression of UrSTR1/5 in UR hairy roots constitutively increased the biosynthesis of bioactive UR-MIAs (rhynchophylline, isorh …
Dual modulators of aggregation and dissociation of amyloid beta and tau: In vitro, in vivo, and in silico studies of Uncaria rhynchophylla and its bioactive components.
Kim S, Nam Y, Shin SJ, Prajapati R, Shin SM, Kim MJ, Soo Kim H, Leem SH, Kim TJ, Park YH, Kim JJ, Choi JS, Moon M. Kim S, et al. Biomed Pharmacother. 2022 Dec;156:113865. doi: 10.1016/j.biopha.2022.113865. Epub 2022 Oct 13. Biomed Pharmacother. 2022. PMID: 36242849 Free article.
In addition, histological study revealed an inhibitory effect of UR on the accumulation of Abeta and tau and AD-related pathologies in 3xTg mice with both Abeta and tau pathology. Furthermore, we found that rhynchophylline and corynoxeine, bioactive components of UR, could …
In addition, histological study revealed an inhibitory effect of UR on the accumulation of Abeta and tau and AD-related pathologies in 3xTg …
Rapid screening of hepatotoxic components in Uncariae Ramulus Cum Uncis based on "component-target-pathway" network.
Zhang X, Wang S, Shu L, Zhao S, Yan X, Jia G, Zhang Y, Zhang W, Qian W, Yang B, Li Y. Zhang X, et al. J Pharm Biomed Anal. 2022 Sep 20;219:114968. doi: 10.1016/j.jpba.2022.114968. Epub 2022 Jul 26. J Pharm Biomed Anal. 2022. PMID: 35926328
As a result, 40 components and 39 ingredients were identified in UR and US, respectively. Cadambine, rhynchophylline, corynoxeine, isocorynoxeine, strictosamide and mitraphylline were screened as the potential hepatotoxic ingredients contained both in UR and US. ...
As a result, 40 components and 39 ingredients were identified in UR and US, respectively. Cadambine, rhynchophylline, corynoxeine, is …
59 results