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2009 1
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39 results

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Page 1
Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer.
Liu M, Zhang Y, Yang J, Zhan H, Zhou Z, Jiang Y, Shi X, Fan X, Zhang J, Luo W, Fung KA, Xu C, Bronze MS, Houchen CW, Li M. Liu M, et al. Among authors: houchen cw. Gastroenterology. 2021 Apr;160(5):1771-1783.e1. doi: 10.1053/j.gastro.2020.12.077. Epub 2021 Jan 6. Gastroenterology. 2021. PMID: 33421513 Free PMC article.
Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota.
Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. Bergstrom K, et al. Among authors: houchen cw. Science. 2020 Oct 23;370(6515):467-472. doi: 10.1126/science.aay7367. Science. 2020. PMID: 33093110 Free PMC article.
ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism.
Liu M, Yang J, Zhang Y, Zhou Z, Cui X, Zhang L, Fung KM, Zheng W, Allard FD, Yee EU, Ding K, Wu H, Liang Z, Zheng L, Fernandez-Zapico ME, Li YP, Bronze MS, Morris KT, Postier RG, Houchen CW, Yang J, Li M. Liu M, et al. Among authors: houchen cw. Clin Cancer Res. 2018 Jul 1;24(13):3186-3196. doi: 10.1158/1078-0432.CCR-18-0263. Epub 2018 Apr 3. Clin Cancer Res. 2018. PMID: 29615456 Free PMC article.
Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer.
Ge Y, Weygant N, Qu D, May R, Berry WL, Yao J, Chandrakesan P, Zheng W, Zhao L, Zhao KL, Drake M, Vega KJ, Bronze MS, Tomasek JJ, An G, Houchen CW. Ge Y, et al. Among authors: houchen cw. Int J Cancer. 2018 Sep 1;143(5):1162-1175. doi: 10.1002/ijc.31400. Epub 2018 Apr 16. Int J Cancer. 2018. PMID: 29577277 Free PMC article.
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity.
Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ. Yan KS, et al. Among authors: houchen cw. Cell Stem Cell. 2017 Jul 6;21(1):78-90.e6. doi: 10.1016/j.stem.2017.06.014. Cell Stem Cell. 2017. PMID: 28686870 Free PMC article.
(Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression.
Nguyen CB, Kotturi H, Waris G, Mohammed A, Chandrakesan P, May R, Sureban S, Weygant N, Qu D, Rao CV, Dhanasekaran DN, Bronze MS, Houchen CW, Ali N. Nguyen CB, et al. Among authors: houchen cw. Cancer Res. 2016 Aug 15;76(16):4887-96. doi: 10.1158/0008-5472.CAN-15-2722. Epub 2016 Jun 10. Cancer Res. 2016. PMID: 27287718 Free PMC article.
Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase.
Weygant N, Ge Y, Qu D, Kaddis JS, Berry WL, May R, Chandrakesan P, Bannerman-Menson E, Vega KJ, Tomasek JJ, Bronze MS, An G, Houchen CW. Weygant N, et al. Among authors: houchen cw. Cancer Res. 2016 Jul 15;76(14):4090-9. doi: 10.1158/0008-5472.CAN-16-0029. Epub 2016 Jun 10. Cancer Res. 2016. PMID: 27287716 Free PMC article.
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.
Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L. Bergstrom K, et al. Among authors: houchen cw. Gastroenterology. 2016 Jul;151(1):152-164.e11. doi: 10.1053/j.gastro.2016.03.039. Epub 2016 Apr 6. Gastroenterology. 2016. PMID: 27059389 Free PMC article.
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.
Westphalen CB, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz BW, Chen X, Ormanns S, Nagar K, Tailor Y, May R, Cho Y, Asfaha S, Worthley DL, Hayakawa Y, Urbanska AM, Quante M, Reichert M, Broyde J, Subramaniam PS, Remotti H, Su GH, Rustgi AK, Friedman RA, Honig B, Califano A, Houchen CW, Olive KP, Wang TC. Westphalen CB, et al. Among authors: houchen cw. Cell Stem Cell. 2016 Apr 7;18(4):441-55. doi: 10.1016/j.stem.2016.03.016. Cell Stem Cell. 2016. PMID: 27058937 Free PMC article.
ZIP4 silencing improves bone loss in pancreatic cancer.
Zhang Q, Sun X, Yang J, Ding H, LeBrun D, Ding K, Houchen CW, Postier RG, Ambrose CG, Li Z, Bi X, Li M. Zhang Q, et al. Among authors: houchen cw. Oncotarget. 2015 Sep 22;6(28):26041-51. doi: 10.18632/oncotarget.4667. Oncotarget. 2015. PMID: 26305676 Free PMC article.
Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression.
Mohammed A, Janakiram NB, Madka V, Brewer M, Ritchie RL, Lightfoot S, Kumar G, Sadeghi M, Patlolla JM, Yamada HY, Cruz-Monserrate Z, May R, Houchen CW, Steele VE, Rao CV. Mohammed A, et al. Among authors: houchen cw. Oncotarget. 2015 Jun 20;6(17):15524-39. doi: 10.18632/oncotarget.3499. Oncotarget. 2015. PMID: 25906749 Free PMC article.
Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells.
Qu D, Johnson J, Chandrakesan P, Weygant N, May R, Aiello N, Rhim A, Zhao L, Zheng W, Lightfoot S, Pant S, Irvan J, Postier R, Hocker J, Hanas JS, Ali N, Sureban SM, An G, Schlosser MJ, Stanger B, Houchen CW. Qu D, et al. Among authors: houchen cw. PLoS One. 2015 Feb 27;10(2):e0118933. doi: 10.1371/journal.pone.0118933. eCollection 2015. PLoS One. 2015. PMID: 25723399 Free PMC article.
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma.
Weygant N, Qu D, May R, Tierney RM, Berry WL, Zhao L, Agarwal S, Chandrakesan P, Chinthalapally HR, Murphy NT, Li JD, Sureban SM, Schlosser MJ, Tomasek JJ, Houchen CW. Weygant N, et al. Among authors: houchen cw. Oncotarget. 2015 Feb 10;6(4):2193-205. doi: 10.18632/oncotarget.3059. Oncotarget. 2015. PMID: 25605241 Free PMC article.
Translational research on Barrett's esophagus.
Baruah A, Buttar N, Chandra R, Chen X, Clemons NJ, Compare D, El-Rifai W, Gu J, Houchen CW, Koh SY, Li W, Nardone G, Phillips WA, Sharma A, Singh I, Upton MP, Vega KJ, Wu X. Baruah A, et al. Among authors: houchen cw. Ann N Y Acad Sci. 2014 Sep;1325:170-86. doi: 10.1111/nyas.12531. Ann N Y Acad Sci. 2014. PMID: 25266024
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
Sureban SM, May R, Weygant N, Qu D, Chandrakesan P, Bannerman-Menson E, Ali N, Pantazis P, Westphalen CB, Wang TC, Houchen CW. Sureban SM, et al. Among authors: houchen cw. Cancer Lett. 2014 Aug 28;351(1):151-61. doi: 10.1016/j.canlet.2014.05.011. Epub 2014 May 28. Cancer Lett. 2014. PMID: 24880079
Long-lived intestinal tuft cells serve as colon cancer-initiating cells.
Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC. Westphalen CB, et al. Among authors: houchen cw. J Clin Invest. 2014 Mar;124(3):1283-95. doi: 10.1172/JCI73434. J Clin Invest. 2014. PMID: 24487592 Free PMC article.
Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury.
Qu D, May R, Sureban SM, Weygant N, Chandrakesan P, Ali N, Li L, Barrett T, Houchen CW. Qu D, et al. Among authors: houchen cw. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G404-11. doi: 10.1152/ajpgi.00088.2013. Epub 2013 Dec 24. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 24368703 Free PMC article.
Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism.
Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW. Ali N, et al. Among authors: houchen cw. PLoS One. 2013 Nov 19;8(11):e80304. doi: 10.1371/journal.pone.0080304. eCollection 2013. PLoS One. 2013. PMID: 24260365 Free PMC article.
Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis.
Bishnupuri KS, Luo Q, Sainathan SK, Kikuchi K, Sureban SM, Sabarinathan M, Gross JH, Aden K, May R, Houchen CW, Anant S, Dieckgraefe BK. Bishnupuri KS, et al. Among authors: houchen cw. Gastroenterology. 2010 Feb;138(2):616-26, 626.e1-2. doi: 10.1053/j.gastro.2009.10.050. Epub 2009 Nov 10. Gastroenterology. 2010. PMID: 19900450 Free PMC article.