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Unique Changes in the Incidence of Acute Chest Syndrome in Children With Sickle Cell Disease Unravel the Role of Respiratory Pathogens: A Time Series Analysis.
Assad Z, Valtuille Z, Rybak A, Kaguelidou F, Lazzati A, Varon E, Pham LL, Lenglart L, Faye A, Caseris M, Cohen R, Levy C, Vabret A, Gravey F, Angoulvant F, Koehl B, Ouldali N. Assad Z, et al. Chest. 2024 Jan;165(1):150-160. doi: 10.1016/j.chest.2023.07.4219. Epub 2023 Aug 5. Chest. 2024. PMID: 37544426
We hypothesized that the incidence of ACS followed the unprecedented population-level changes in respiratory pathogen dynamics after COVID-19-related nonpharmaceutical interventions (NPIs). RESEARCH QUESTION: What is the respective role of respiratory pathogens in A …
We hypothesized that the incidence of ACS followed the unprecedented population-level changes in respiratory pathogen dynamics after COVI
Impact of COVID-19 on the management of hepatocellular carcinoma in a high-prevalence area: What's new 12 months later?
Brustia R, Bouattour M, Allaire M, Lequoy M, Hollande C, Regnault H, Blaise L, Ganne-Carrié N, Vilgrain V, Larrey E, Lim C, Scatton O, Mouhadi SE, Ozenne V, Paye F, Balladur P, Dohan A, Massault PP, Pol S, Dioguardi Burgio M, Sepulveda A, Cauchy F, Luciani A, Sommacale D, Leroy V, Calderaro J, Roudot-Thoraval F, Nault JC, Amaddeo G; “Paris Liver Cancer Group”. Brustia R, et al. Ann Hepatol. 2023 Nov-Dec;28(6):101141. doi: 10.1016/j.aohep.2023.101141. Epub 2023 Jul 17. Ann Hepatol. 2023. PMID: 37468096 Free article.
INTRODUCTION AND OBJECTIVES: The lockdown policy introduced in 2020 to minimize the spread of the COVID-19 pandemic, significantly affected the management and care of patients affected by hepatocellular carcinoma (HCC). The aim of this follow-up study was to determi …
INTRODUCTION AND OBJECTIVES: The lockdown policy introduced in 2020 to minimize the spread of the COVID-19 pandemic, significa …
Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines.
Chauvin C, Retnakumar SV, Bayry J. Chauvin C, et al. Cell Rep Med. 2023 Jul 18;4(7):101117. doi: 10.1016/j.xcrm.2023.101117. Cell Rep Med. 2023. PMID: 37467723 Free PMC article.
Severe obesity accelerates the decline of neutralizing antibodies to COVID-19 vaccines contributing to increased risk of hospitalization from breakthrough SARS-CoV-2 infections.(1) These findings have repercussion on the vaccination policy for …
Severe obesity accelerates the decline of neutralizing antibodies to COVID-19 vaccines contributing to increased risk of hospi …
Antiviral activities of sotrovimab against BQ.1.1 and XBB.1.5 in sera of treated patients.
Bruel T, Vrignaud LL, Porrot F, Staropoli I, Planas D, Guivel-Benhassine F, Puech J, Prot M, Munier S, Henry-Bolland W, Soulié C, Zafilaza K, Lusivika-Nzinga C, Meledge ML, Dorival C, Molino D, Péré H, Yordanov Y, Simon-Lorière E, Veyer D, Carrat F, Schwartz O, Marcelin AG, Martin-Blondel G; ANRS 0003S CoCoPrev Study Group. Bruel T, et al. medRxiv [Preprint]. 2023 May 30:2023.05.25.23290512. doi: 10.1101/2023.05.25.23290512. medRxiv. 2023. PMID: 37398037 Free PMC article. Preprint.
BACKGROUND: Monoclonal antibodies (mAbs) targeting the spike of SARS-CoV-2 prevent severe COVID-19. Omicron subvariants BQ.1.1 and XBB.1.5 evade neutralization of therapeutic mAbs, leading to recommendations against their use. ...METHODS: We inv …
BACKGROUND: Monoclonal antibodies (mAbs) targeting the spike of SARS-CoV-2 prevent severe COVID-19. Omicr …
The FLURESP European commission project: cost-effectiveness assessment of ten public health measures against influenza in Italy: is there an interest in COVID-19 pandemic?
Beresniak A, Napoli C, Oxford J, Daruich A, Niddam L, Duru G, Tozzi AE, Atti MCD, Dupont D, Rizzo C, Bremond-Gignac D. Beresniak A, et al. Cost Eff Resour Alloc. 2023 May 15;21(1):30. doi: 10.1186/s12962-023-00432-0. Cost Eff Resour Alloc. 2023. PMID: 37189126 Free PMC article.
As most of interventions against human influenza are relavant against other respiratory diseases pandemics, potential interests in COVID-19 are discussed. METHODS: Ten public health measures against human influenza pandemics pandemic were selected to be also relevan …
As most of interventions against human influenza are relavant against other respiratory diseases pandemics, potential interests in COVID
Defective Immunity Against SARS-CoV-2 Omicron Variants Despite Full Vaccination in Hematologic Malignancies.
Zitvogel L, Derosa L, Kroemer G. Zitvogel L, et al. Blood Cancer Discov. 2023 May 1;4(3):172-175. doi: 10.1158/2643-3230.BCD-22-0213. Blood Cancer Discov. 2023. PMID: 37078891 Free PMC article.
In patients with multiple myeloma, completion of mRNA-based vaccination schemes failed to yield detectable SARS-CoV-2 Omicron-neutralizing antibodies and S1-RBD-specific CD8+ T cells in approximately 60% and 80% of the cases, respectively. ...
In patients with multiple myeloma, completion of mRNA-based vaccination schemes failed to yield detectable SARS-CoV-2 O …
Fibrin monomers evaluation during hospitalization for COVID-19 is a predictive marker of in-hospital mortality.
Smadja DM, Gendron N, Philippe A, Diehl JL, Ochat N, Bory O, Beauvais A, Mareau A, Jannot AS, Chocron R. Smadja DM, et al. Front Cardiovasc Med. 2023 Mar 30;10:1001530. doi: 10.3389/fcvm.2023.1001530. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37063947 Free PMC article.
METHODS: We performed a monocentric study of adult patients with COVID-19, who were admitted either in the medical ward (MW) or in the intensive care unit (ICU) and who had FM measurements performed on them during the first wave of COVID-19 outbreak. . …
METHODS: We performed a monocentric study of adult patients with COVID-19, who were admitted either in the medical ward (MW) o …
The implication of anti-PD-1 therapy in cancer patients for the vaccination against viral and other infectious diseases.
Retnakumar SV, Chauvin C, Bayry J. Retnakumar SV, et al. Pharmacol Ther. 2023 May;245:108399. doi: 10.1016/j.pharmthera.2023.108399. Epub 2023 Mar 30. Pharmacol Ther. 2023. PMID: 37001736 Review.
When it comes to vaccinating anti-PD-1-treated cancer patients against infectious diseases including COVID-19 and influenza, a special focus should be brought on the revived immune cells, which could be dynamically affected by the antigenic stimulation. ...
When it comes to vaccinating anti-PD-1-treated cancer patients against infectious diseases including COVID-19 and influenza, a …
Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics.
Bourgin M, Durand S, Kroemer G. Bourgin M, et al. Metabolites. 2023 Feb 24;13(3):342. doi: 10.3390/metabo13030342. Metabolites. 2023. PMID: 36984782 Free PMC article. Review.
A number of studies have assessed the impact of SARS-CoV-2 infection and COVID-19 severity on the metabolome of exhaled air, saliva, plasma, and urine to identify diagnostic and prognostic biomarkers. ...Several among the metabolites that are un …
A number of studies have assessed the impact of SARS-CoV-2 infection and COVID-19 severity on the metabol …
Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study.
Giabicani M, Le Terrier C, Poncet A, Guidet B, Rigaud JP, Quenot JP, Mamzer MF, Pugin J, Weiss E, Bourcier S; COVID-ICU study investigators. Giabicani M, et al. Crit Care. 2023 Mar 11;27(1):103. doi: 10.1186/s13054-023-04349-1. Crit Care. 2023. PMID: 36906643 Free PMC article.
However, scarce data were available during the COVID-19 pandemic when ICUs were under intense pressure. We aimed to investigate the prevalence, cumulative incidence, timing, modalities, and factors associated with LST decisions in critically ill COVID-19
However, scarce data were available during the COVID-19 pandemic when ICUs were under intense pressure. We aimed to investigat …
General practitioners' perceptions of using virtual primary care during the COVID-19 pandemic: An international cross-sectional survey study.
Li E, Tsopra R, Jimenez G, Serafini A, Gusso G, Lingner H, Fernandez MJ, Irving G, Petek D, Hoffman R, Lazic V, Memarian E, Koskela T, Collins C, Espitia SM, Clavería A, Nessler K, O'Neill BG, Hoedebecke K, Ungan M, Laranjo L, Ghafur S, Fontana G, Majeed A, Car J, Darzi A, Neves AL. Li E, et al. PLOS Digit Health. 2022 May 16;1(5):e0000029. doi: 10.1371/journal.pdig.0000029. eCollection 2022 May. PLOS Digit Health. 2022. PMID: 36812543 Free PMC article.
With the onset of COVID-19, general practitioners (GPs) and patients worldwide swiftly transitioned from face-to-face to digital remote consultations. ...The benefits identified included reducing COVID-19 transmission risks, guaranteeing access and con …
With the onset of COVID-19, general practitioners (GPs) and patients worldwide swiftly transitioned from face-to-face to digit …
Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies.
Planas D, Bruel T, Staropoli I, Guivel-Benhassine F, Porrot F, Maes P, Grzelak L, Prot M, Mougari S, Planchais C, Puech J, Saliba M, Sahraoui R, Fémy F, Morel N, Dufloo J, Sanjuán R, Mouquet H, André E, Hocqueloux L, Simon-Loriere E, Veyer D, Prazuck T, Péré H, Schwartz O. Planas D, et al. Nat Commun. 2023 Feb 14;14(1):824. doi: 10.1038/s41467-023-36561-6. Nat Commun. 2023. PMID: 36788246 Free PMC article.
Convergent evolution of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 lineages has led to the emergence of several new subvariants, including BA.2.75.2, BA.4.6. and BQ.1.1. ...
Convergent evolution of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 lineages has led to the emergence of several new subvar …
Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants.
Chauvin C, Levillayer L, Roumier M, Nielly H, Roth C, Karnam A, Bonam SR, Bourgarit A, Dubost C, Bousquet A, Le Burel S, Mestiri R, Sene D, Galland J, Vasse M, Groh M, Le Marchand M, Vassord-Dang C, Gautier JF, Pham-Thi N, Verny C, Pitard B, Planchais C, Mouquet H, Paul R, Simon-Loriere E, Bayry J, Gilardin L, Sakuntabhai A. Chauvin C, et al. iScience. 2023 Mar 17;26(3):106124. doi: 10.1016/j.isci.2023.106124. Epub 2023 Feb 3. iScience. 2023. PMID: 36776936 Free PMC article.
Although tocilizumab treatment in severe and critical coronavirus disease 2019 (COVID-19) patients has proven its efficacy at the clinical level, there is little evidence supporting the effect of short-term use of interleukin-6 receptor blocking therapy on the B cel …
Although tocilizumab treatment in severe and critical coronavirus disease 2019 (COVID-19) patients has proven its efficacy at …
The dental triage method at Rothschild Hospital during the first lockdown due to the COVID-19 pandemic.
Saade Y, de la Dure Molla M, Fournier BPJ, Kerner S, Colon P, Carra MC, Bouchard P. Saade Y, et al. PLoS One. 2023 Feb 8;18(2):e0281390. doi: 10.1371/journal.pone.0281390. eCollection 2023. PLoS One. 2023. PMID: 36753528 Free PMC article.
OBJECTIVE: This study aims to (1) assess the efficacy of a face-to-face emergency protocol in children and adults and (2) measure the efficacies of prediagnosis at the triage level and clinical diagnosis at the emergency department level during the COVID-19 pandemic …
OBJECTIVE: This study aims to (1) assess the efficacy of a face-to-face emergency protocol in children and adults and (2) measure the effica …
Cardiac adipose tissue volume assessed by computed tomography is a specific and independent predictor of early mortality and critical illness in COVID-19 in type 2-diabetic patients.
Charpentier E, Redheuil A, Bourron O, Boussouar S, Lucidarme O, Zarai M, Kachenoura N, Bouazizi K, Salem JE, Hekimian G, Kerneis M, Amoura Z, Allenbach Y, Hatem S, Jeannin AC, Andreelli F, Phan F; COVID-19 APHP. SU Group. Charpentier E, et al. Cardiovasc Diabetol. 2022 Dec 31;21(1):294. doi: 10.1186/s12933-022-01722-2. Cardiovasc Diabetol. 2022. PMID: 36587209 Free PMC article.
As visceral adiposity is associated with severe COVID-19 irrespective of obesity, we aimed to evaluate and compare the predictive value for early intensive care or death of three fat depots (cardiac, visceral and subcutaneous) using computed tomography (CT) at admis …
As visceral adiposity is associated with severe COVID-19 irrespective of obesity, we aimed to evaluate and compare the predict …
Impact of the COVID-19 pandemic on the care of rare and undiagnosed diseases patients in France: a longitudinal population-based study.
Soussand L, Kuchenbuch M, Messiaen C, Sandrin A, Jannot AS, Nabbout R. Soussand L, et al. Orphanet J Rare Dis. 2022 Dec 9;17(1):430. doi: 10.1186/s13023-022-02580-7. Orphanet J Rare Dis. 2022. PMID: 36494730 Free PMC article.
BACKGROUND: Preliminary data suggest that COVID-19 pandemic has generated a switch from face-to-face to remote care for individuals with chronic diseases. However, few data are available for rare and undiagnosed diseases (RUDs). We aimed to assess the impact of the …
BACKGROUND: Preliminary data suggest that COVID-19 pandemic has generated a switch from face-to-face to remote care for indivi …
Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies.
Planas D, Bruel T, Staropoli I, Guivel-Benhassine F, Porrot F, Maes P, Grzelak L, Prot M, Mougari S, Planchais C, Puech J, Saliba M, Sahraoui R, Fémy F, Morel N, Dufloo J, Sanjuán R, Mouquet H, André E, Hocqueloux L, Simon-Loriere E, Veyer D, Prazuck T, Péré H, Schwartz O. Planas D, et al. bioRxiv [Preprint]. 2022 Nov 21:2022.11.17.516888. doi: 10.1101/2022.11.17.516888. bioRxiv. 2022. Update in: Nat Commun. 2023 Feb 14;14(1):824. doi: 10.1038/s41467-023-36561-6. PMID: 36415455 Free PMC article. Updated. Preprint.
Convergent evolution of SARS-CoV-2 Omicron BA.2, BA.4 and BA.5 lineages has led to the emergence of several new subvariants, including BA.2.75.2, BA.4.6. and BQ.1.1. ...
Convergent evolution of SARS-CoV-2 Omicron BA.2, BA.4 and BA.5 lineages has led to the emergence of several new subvari …
Analysis of COVID-19 Vaccination Status Among Parents of Hospitalized Children Younger Than 5 Years With SARS-CoV-2 Infection During the Delta and Omicron Waves.
Solignac F, Ouldali N, Aupiais C, Casha P, Cohen R, Levy C, Angoulvant F. Solignac F, et al. JAMA Netw Open. 2022 Nov 1;5(11):e2242295. doi: 10.1001/jamanetworkopen.2022.42295. JAMA Netw Open. 2022. PMID: 36383384 Free PMC article.
This cohort study uses COVID-19 Pediatric Observatory study data to analyze the vaccination status of parents with young children hospitalized for SARS-CoV-2 variants Delta and Omicron....
This cohort study uses COVID-19 Pediatric Observatory study data to analyze the vaccination status of parents with young child …
Prevalence of Contraindications to Nirmatrelvir-Ritonavir Among Hospitalized Patients With COVID-19 at Risk for Progression to Severe Disease.
Hoertel N, Boulware DR, Sánchez-Rico M, Burgun A, Limosin F. Hoertel N, et al. JAMA Netw Open. 2022 Nov 1;5(11):e2242140. doi: 10.1001/jamanetworkopen.2022.42140. JAMA Netw Open. 2022. PMID: 36378313 Free PMC article.
This cohort study examines the prevalence of contraindications to nirmatrelvir-ritonavir in patients hospitalized with COVID-19....
This cohort study examines the prevalence of contraindications to nirmatrelvir-ritonavir in patients hospitalized with COVID-19
Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2.
Planchais C, Reyes-Ruiz A, Lacombe R, Zarantonello A, Lecerf M, Revel M, Roumenina LT, Atanasov BP, Mouquet H, Dimitrov JD. Planchais C, et al. Protein Sci. 2022 Nov;31(11):e4447. doi: 10.1002/pro.4447. Protein Sci. 2022. PMID: 36305765 Free PMC article.
SARS-CoV-2 infects cells by attachment to its receptor-the angiotensin converting enzyme 2 (ACE2). ...Data from various binding assays revealed that SARS-CoV-2 Wuhan and Omicron RBDs manifest capacity for promiscuous recognition of unrela
SARS-CoV-2 infects cells by attachment to its receptor-the angiotensin converting enzyme 2 (ACE2). ...Data from various
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