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Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial.
Ziegler AG, Achenbach P, Weiß A, Berner R, Casteels K, Elding Larsson H, Haupt F, Hommel A, Jacobs A, Kordonouri O, Lundgren M, Ołtarzewski M, Pfirrmann M, Snape MD, Szypowska A, Todd JA, Vatish M, von dem Berge T, Winkler C, Bonifacio E; GPPAD-POInT Study Group. Ziegler AG, et al. Lancet. 2025 Nov 29;406(10519):2564-2576. doi: 10.1016/S0140-6736(25)01726-X. Epub 2025 Nov 11. Lancet. 2025. PMID: 41237794 Free article. Clinical Trial.
BACKGROUND: Type 1 diabetes begins with autoimmunity against pancreatic islet antigens, including insulin. ...METHODS: In this randomised, controlled, primary prevention trial, genetic screening in seven obstetric and paediatric clinics in Germany, Pol …
BACKGROUND: Type 1 diabetes begins with autoimmunity against pancreatic islet antigens, including insulin. ...METHODS: …
Spatiotemporal associations between incidence of type 1 diabetes and COVID-19 vaccination rates in children in Germany - a population-based ecological study.
Kamrath C, Eckert AJ, Lignitz S, Hillenbrand N, Dost A, Warncke K, Klose D, Grohmann-Held K, Holl RW, Rosenbauer J. Kamrath C, et al. J Pediatr Endocrinol Metab. 2025 Sep 16;38(11):1117-1125. doi: 10.1515/jpem-2025-0189. Print 2025 Nov 25. J Pediatr Endocrinol Metab. 2025. PMID: 40966678 Free article.
OBJECTIVES: The incidence of type 1 diabetes (T1D) in children increased during the first two years of the COVID-19 pandemic and declined thereafter. ...Neither the month-averaged spatial analysis (5-11 years: r=-0.029 [95%CI -0.136; 0.079]; 12- …
OBJECTIVES: The incidence of type 1 diabetes (T1D) in children increased during the first two years of the COVID …
Epigenetic differences at immune and type 1 diabetes susceptibility genes in blood from young children after COVID-19 infection.
Ott R, Singh T, Schütte-Borkovec K, Scholz M, Casteels K, Gemulla G, Kordonouri O, Elding Larsson H, Szypowska A, Todd JA, Ziegler AG, Bonifacio E. Ott R, et al. J Autoimmun. 2025 Sep;156:103468. doi: 10.1016/j.jaut.2025.103468. Epub 2025 Jul 31. J Autoimmun. 2025. PMID: 40749537 Free article.
BACKGROUND: Viral infections, including COVID-19, are associated with an increased risk for type 1 diabetes (T1D), but potential underlying mechanisms remain unexplored. ...In addition to ADAR, six further T1D susceptibility genes, including the …
BACKGROUND: Viral infections, including COVID-19, are associated with an increased risk for type 1 diabetes …
Physiological Activities of Adiponectin Provide Therapeutic Opportunities in Sepsis.
Grewal T, Buechler C. Grewal T, et al. Front Biosci (Landmark Ed). 2025 Jun 17;30(6):26129. doi: 10.31083/FBL26129. Front Biosci (Landmark Ed). 2025. PMID: 40613275 Free article. Review.
In addition, several immunoregulatory activities of adiponectin have been described and circulating adiponectin levels have been positively associated with inflammation in autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. Although an under …
In addition, several immunoregulatory activities of adiponectin have been described and circulating adiponectin levels have been positively …
Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and beta-cell autoimmunity.
Almutawif YA, Al-Kuraishy HM, Al-Gareeb AI, Albuhadily AK, Eid HMA, Alexiou A, Papadakis M, Abo-El Fetoh ME, El-Saber Batiha G. Almutawif YA, et al. Virol J. 2025 Jun 14;22(1):195. doi: 10.1186/s12985-025-02822-7. Virol J. 2025. PMID: 40517247 Free PMC article. Review.
Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 diabetes (T1D). This article analyzes the possible methods for MPXV infection to induce autoimmune responses and damage pancreatic beta-c …
Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 d …
Remission Period in Children With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic-Results From the DPV Registry.
Lahn V, Tittel SR, Ohlenschläger U, Kamrath C, Hammersen J, Gellai R, Mönkemöller K, Dost A, Bartelt H, Holl RW. Lahn V, et al. Pediatr Diabetes. 2025 May 15;2025:9903467. doi: 10.1155/pedi/9903467. eCollection 2025. Pediatr Diabetes. 2025. PMID: 40406224 Free PMC article.
To investigate whether the remission period in type 1 diabetes, as measured by insulin-dose adjusted A1c (IDAA1C), was affected by the COVID-19 pandemic. Data from 7603 children and adolescents with type 1 diabetes from the …
To investigate whether the remission period in type 1 diabetes, as measured by insulin-dose adjusted A1c (IDAA1C), was …
The changes in global burden of autoimmune diseases two years after the COVID-19 pandemic: a trend analysis based on the Global Burden of Disease Study 2021.
Zhang D, Hua W, Sun F, Wen C, Cheong LY, Xie R, Chan KH, Chan SCW, Li X, Ye S, Yap DYH. Zhang D, et al. J Transl Autoimmun. 2025 Apr 24;10:100289. doi: 10.1016/j.jtauto.2025.100289. eCollection 2025 Jun. J Transl Autoimmun. 2025. PMID: 40342869 Free PMC article. Review.
BACKGROUND: Data on the epidemiological changes in the global burden of autoimmune diseases (ADs) after the Coronavirus disease 2019 (COVID-19) pandemic is lacking. This study investigated the impact of the COVID-19 pandemic on the global burden of ADs …
BACKGROUND: Data on the epidemiological changes in the global burden of autoimmune diseases (ADs) after the Coronavirus disease 2019 (COV …
Did smoking behavior change in adolescents and young adults with and without diabetes during the COVID-19 pandemic? A cohort study from the DPV registry.
Warncke K, Hofer SE, von Sengbusch S, Ermer U, Niemeyer M, Lemmer A, Hilgard D, Welters A, Holl RW, Eckert AJ. Warncke K, et al. BMC Pediatr. 2025 Mar 27;25(1):236. doi: 10.1186/s12887-025-05434-w. BMC Pediatr. 2025. PMID: 40140736 Free PMC article.
BACKGROUND: Smoking is a risk factor for cardiovascular complications and can promote a severe course of COVID-19 infection. The aim of this study was to compare smoking habits of young people with diabetes with the general population. ...Smoking behavior between T1 …
BACKGROUND: Smoking is a risk factor for cardiovascular complications and can promote a severe course of COVID-19 infection. T …
Impact of the COVID-19 Pandemic on Psychosocial Distress in Adolescents with Obesity Compared to Those with Type 1 Diabetes: Results from the KICK-COVID Study in Germany.
Weihrauch-Blüher S, Wiegand S, Tittel S, Greber-Platzer S, Lanzinger S, Kamrath C, Minden K, Sengler C, Linke S, Büssenschütt A, Reschke F, Göldel J, Warschburger P, Holl RW. Weihrauch-Blüher S, et al. Obes Facts. 2025;18(3):305-318. doi: 10.1159/000542756. Epub 2025 Feb 17. Obes Facts. 2025. PMID: 39961287 Free PMC article.
INTRODUCTION: The aim of this study was to investigate the impact of the COVID-19 pandemic on psychosocial well-being in adolescents with obesity compared to those with type 1 diabetes. ...CONCLUSIONS: Youth with obesity and diabetes experienced …
INTRODUCTION: The aim of this study was to investigate the impact of the COVID-19 pandemic on psychosocial well-being in adole …
88 results