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Exploring yeast glucans for vaccine enhancement: Sustainable strategies for overcoming adjuvant challenges in a SARS-CoV-2 model.
Azevedo-Silva J, Amorim M, Tavares-Valente D, Sousa P, Mohamath R, Voigt EA, Guderian JA, Kinsey R, Viana S, Reis F, Pintado ME, Paddon CJ, Fox CB, Fernandes JC. Azevedo-Silva J, et al. Eur J Pharm Biopharm. 2024 Dec;205:114538. doi: 10.1016/j.ejpb.2024.114538. Epub 2024 Oct 24. Eur J Pharm Biopharm. 2024. PMID: 39461571 Free article.
These glucans underwent carboxymethylation to enhance solubility. Both water-dispersible and particulate glucans were evaluated as adjuvants, either alone or in combination with Alum or squalene stable emulsion (SE), for a SARS-CoV-2 vaccine. .. …
These glucans underwent carboxymethylation to enhance solubility. Both water-dispersible and particulate glucans were evaluate …
Prognostic model for gastric cancer patients with COVID-19 and network pharmacology study on treatment by lentinan.
Zhou S, Sun H. Zhou S, et al. Sci Rep. 2024 Oct 20;14(1):24645. doi: 10.1038/s41598-024-76783-2. Sci Rep. 2024. PMID: 39428405 Free PMC article.
We hypothesized that lentinan might exert powerful pharmacological effects in patients with GC and COVID-19. In this study, a prognostic model of patients with GC/COVID-19 was constructed and used to apply a network pharmacology approach to reveal biol …
We hypothesized that lentinan might exert powerful pharmacological effects in patients with GC and COVID-19. In this study, a …
Preparation and immunological activity evaluation of an intranasal protein subunit vaccine against ancestral and mutant SARS-CoV-2 with curdlan sulfate/O-linked quaternized chitosan nanoparticles as carrier and adjuvant.
Chen Y, Wang Y, Li Z, Jiang H, Pan W, Liu M, Jiang W, Zhang X, Wang F. Chen Y, et al. Int J Biol Macromol. 2024 Sep;276(Pt 1):133733. doi: 10.1016/j.ijbiomac.2024.133733. Epub 2024 Jul 11. Int J Biol Macromol. 2024. PMID: 39002905
Previously, we successfully used a chitosan derivative, O-(2-Hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (O-HTCC), and a beta-glucan derivative, curdlan sulfate (CS), to prepare a nanoparticle adjuvant CS/O-HTCC which could deliver ovalbumin to antigen presenti …
Previously, we successfully used a chitosan derivative, O-(2-Hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (O-HTCC), and a beta …
Is there an interest in systematic serum screening for aspergillosis in COVID-19 patients in a medical ward?
Gerber V, Boehn L, Sabou M, Studer A, Ursenbach A, Hansmann Y, Herbrecht R, Lefebvre N, Letscher-Bru V, Danion F. Gerber V, et al. Infect Dis Now. 2024 Jun;54(4):104918. doi: 10.1016/j.idnow.2024.104918. Epub 2024 Apr 16. Infect Dis Now. 2024. PMID: 38636842 Free article.
METHODS: We retrospectively analyzed all patients hospitalized in our infectious disease department from October 1st to October 31st, 2020 for COVID-19 without prior ICU admission, and for whom systematic screening of serum fungal markers was performed. ...CONCLUSIO …
METHODS: We retrospectively analyzed all patients hospitalized in our infectious disease department from October 1st to October 31st, 2020 f …
Persistent fever after coronavirus disease 2019 in liver/kidney transplant recipient.
Mullis CE, Heldman M, Bahr NC, Minamoto GY, Puius YA, Malinis M. Mullis CE, et al. Transpl Infect Dis. 2024 Jun;26(3):e14271. doi: 10.1111/tid.14271. Epub 2024 Apr 11. Transpl Infect Dis. 2024. PMID: 38605533
In this case, a 64-year-old male with a history of simultaneous orthotopic liver transplant and cadaveric renal transplant presented five years prior presented with persistent fevers two days after a positive SARS-CoV-2 nasal PCR. A CT scan of the chest on ho …
In this case, a 64-year-old male with a history of simultaneous orthotopic liver transplant and cadaveric renal transplant presented five ye …
Clinical Evidence on the Potential Beneficial Effects of Diet and Dietary Supplements against COVID-19 Infection Risk and Symptoms' Severity.
Pavlidou E, Poulios E, Papadopoulou SK, Fasoulas A, Dakanalis A, Giaginis C. Pavlidou E, et al. Med Sci (Basel). 2024 Feb 17;12(1):11. doi: 10.3390/medsci12010011. Med Sci (Basel). 2024. PMID: 38390861 Free PMC article. Review.
In the peculiar circumstances of the COVID-19 pandemic, in combination with disease prevention techniques, the strengthening of the immune system is considered particularly important to enable it to effectively respond to and eliminate the SARS-CoV- …
In the peculiar circumstances of the COVID-19 pandemic, in combination with disease prevention techniques, the strengthening o …
Beta 1,3-1,6 Glucans Produced by Two Novel Strains of Aureobasidium Pullulans Exert Immune and Metabolic Beneficial Effects in Healthy Middle-aged Japanese Men: Results of an Exploratory Randomized Control Study.
Ikewaki N, Sonoda T, Kurosawa G, Iwasaki M, Devaprasad Dedeepiya V, Senthilkumar R, Preethy S, Abraham SJK. Ikewaki N, et al. JAR Life. 2023 Jul 28;12:61-71. doi: 10.14283/jarlife.2023.11. eCollection 2023. JAR Life. 2023. PMID: 37637272 Free PMC article.
They were divided into four groups (n = 4 each): Group I consumed AFO-202 beta-glucan (2 sachets of 1 g each per day), IA for 35 days and IB for 21 days; Group II consumed a combination of AFO-202 beta-glucan (2 sachets of 1 g each) and N-163 beta-glucan (1 s …
They were divided into four groups (n = 4 each): Group I consumed AFO-202 beta-glucan (2 sachets of 1 g each per day), IA for 35 days …
Eculizumab suppresses zymosan-induced release of inflammatory cytokines IL-1alpha, IL-1beta, IFN-gamma and IL-2 in autologous serum-substituted PBMC cultures: Relevance to cytokine storm in Covid-19.
Bakos T, Kozma GT, Szebeni J, Szénási G. Bakos T, et al. Biomed Pharmacother. 2023 Oct;166:115294. doi: 10.1016/j.biopha.2023.115294. Epub 2023 Aug 9. Biomed Pharmacother. 2023. PMID: 37567071 Free article.
BACKGROUND AND OBJECTIVE: Cytokine storm (CS) is a major contributor to the fatal outcome of severe infectious diseases, including Covid-19. Treatment with the complement (C) C5 inhibitor eculizumab was beneficial in end-stage Covid-19, however, the me …
BACKGROUND AND OBJECTIVE: Cytokine storm (CS) is a major contributor to the fatal outcome of severe infectious diseases, including Covid …
Chronic Candida albicans meningitis following critical COVID-19 and serial measurements of (1,3)-beta-D-glucan in cerebrospinal fluid.
Andreen N, Brink M, Hammarström H, Yilmaz A. Andreen N, et al. Infect Dis (Lond). 2023 Nov;55(11):794-797. doi: 10.1080/23744235.2023.2232448. Epub 2023 Jul 10. Infect Dis (Lond). 2023. PMID: 37427429
Co-infections with invasive candidiasis have been reported to be overrepresented in severe COVID-19. This report presents an unusual case of chronic Candida meningitis following intensive care for COVID-19....
Co-infections with invasive candidiasis have been reported to be overrepresented in severe COVID-19. This report presents an u …
48 results