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Targeting SARS-CoV-2 variants with Bromelain: an in-silico study of Spike-ACE2 inhibition using docking, molecular dynamic simulation, and MM-PBSA.
Ahuja P, Rao L, Dsouza N. Ahuja P, et al. In Silico Pharmacol. 2025 Oct 17;13(3):157. doi: 10.1007/s40203-025-00446-x. eCollection 2025. In Silico Pharmacol. 2025. PMID: 41113175
SARS-CoV-2, responsible for COVID-19, continue to pose a significant global health challenge due to its high transmissibility and ability to evolve through mutations. ...These findings align with prior studies demonstrating Bromelain's an …
SARS-CoV-2, responsible for COVID-19, continue to pose a significant global health challenge due to its h …
Antiviral effect of Bromelain combined with acetylcysteine against SARS-CoV-2 Omicron variant.
Reis EVS, Ferreira LL, Clarindo FA, Marques-Ferreira G, de Oliveira LC, Moraes TFS, de Carvalho LD, da Fonseca FG, Sabino AP, Eapen MS, Teixeira MM, Valle SJ, Morris DL, Coelho-Dos-Reis JGA. Reis EVS, et al. Sci Rep. 2025 Apr 7;15(1):11882. doi: 10.1038/s41598-025-92242-y. Sci Rep. 2025. PMID: 40195407 Free PMC article.
The recent pandemic represented one of the biggest challenges of modern civilization. SARS-CoV-2 remains an imminent public health threat and currently, there is no effective and greatly affordable treatment for severe COVID-19. ...BromAc( ) can …
The recent pandemic represented one of the biggest challenges of modern civilization. SARS-CoV-2 remains an imminent pu …
Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective.
Sanduzzi Zamparelli S, Sanduzzi Zamparelli A, Bocchino M. Sanduzzi Zamparelli S, et al. Life (Basel). 2025 Jan 16;15(1):113. doi: 10.3390/life15010113. Life (Basel). 2025. PMID: 39860053 Free PMC article. Review.
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has profoundly impacted global health, with pneumonia emerging as a major complication in severe cases. ...Furthermore, these molecules may mitig …
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has p …
Use of high flow nasal cannula in critical burn patient during deep sedation in enzymatic bromelain debridement (nexobrid( )): a single center brief report.
Coletta F, Mataro I, Sala C, Gentile D, Santoriello E, Petroccione C, Schettino F, De Marco GP, Schettini V, Tomasello A, Villani R. Coletta F, et al. Ann Burns Fire Disasters. 2024 Dec 31;37(4):294-299. eCollection 2024 Dec. Ann Burns Fire Disasters. 2024. PMID: 39741773 Free PMC article.
The use of new oxygen supports associated to non-invasive respiratory strategies is well-established in clinical practice, especially after its extensive application in the management of Covid-19 respiratory failure. The use of high flow nasal cannula (HFNC) in pati …
The use of new oxygen supports associated to non-invasive respiratory strategies is well-established in clinical practice, especially after …
Review on Prevalence, Risk Factors, and Research Advancements on the Use of Medical Gloves Concerning Hand Dermatitis Among Health Care Workers.
Gunasegaran J, Teh YY, Lim CK, Ng SF. Gunasegaran J, et al. Saf Health Work. 2024 Jun;15(2):129-138. doi: 10.1016/j.shaw.2024.02.005. Epub 2024 Feb 27. Saf Health Work. 2024. PMID: 39035803 Free PMC article. Review.
The COVID-19 pandemic has led to a significant surge in glove usage, as recommended by the World Health Organization. ...The average prevalence of hand dermatitis among health care workers increased from 21.08% to 37.24% upon the impact of the COVID-19 …
The COVID-19 pandemic has led to a significant surge in glove usage, as recommended by the World Health Organization. ...The a …
Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms.
Kansakar U, Trimarco V, Manzi MV, Cervi E, Mone P, Santulli G. Kansakar U, et al. Nutrients. 2024 Jun 28;16(13):2060. doi: 10.3390/nu16132060. Nutrients. 2024. PMID: 38999808 Free PMC article.
Bromelain is a mixture of proteolytic enzymes primarily extracted from the fruit and stem of the pineapple plant (Ananas comosus). ...This systematic review will delve into the history, structure, chemical properties, and medical indications of bromelain. Bromela …
Bromelain is a mixture of proteolytic enzymes primarily extracted from the fruit and stem of the pineapple plant (Ananas comosus). .. …
Taming the SARS-CoV-2-mediated proinflammatory response with BromAc( ).
Ferreira GM, Clarindo FA, Ribeiro ÁL, Gomes-de-Pontes L, de Carvalho LD, Martins-Filho OA, da Fonseca FG, Teixeira MM, Sabino AP, Eapen MS, Morris DL, Valle SJ, Coelho-Dos-Reis JGA. Ferreira GM, et al. Front Immunol. 2023 Dec 13;14:1308477. doi: 10.3389/fimmu.2023.1308477. eCollection 2023. Front Immunol. 2023. PMID: 38193087 Free PMC article.
INTRODUCTION: In the present study, the impact of BromAc , a specific combination of bromelain and acetylcysteine, on the SARS-CoV-2-specific inflammatory response was evaluated. ...A combined reduction in vascular endothelial growth factor (VEGF) indu …
INTRODUCTION: In the present study, the impact of BromAc , a specific combination of bromelain and acetylcysteine, on the SARS …
Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination.
Hulscher N, Procter BC, Wynn C, McCullough PA. Hulscher N, et al. Cureus. 2023 Nov 21;15(11):e49204. doi: 10.7759/cureus.49204. eCollection 2023 Nov. Cureus. 2023. PMID: 38024037 Free PMC article. Review.
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 vaccination. ...We propose a base spike detoxificatio …
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and be a possible cause of post-ac …
Therapeutic Application of Pineapple: A Review.
Kumar V, Garg V, Dureja H. Kumar V, et al. Recent Adv Food Nutr Agric. 2023;14(2):107-125. doi: 10.2174/2772574X14666230522114039. Recent Adv Food Nutr Agric. 2023. PMID: 37218195 Review.
The plant parts have traditionally been used to treat various ailments, like cancer, diabetes mellitus, bacterial infection, Covid-19 infection, inflammation, arthritis, asthma, malaria, cardiovascular disease, and burn, as debridement agents. ...
The plant parts have traditionally been used to treat various ailments, like cancer, diabetes mellitus, bacterial infection, Covid- …
Effect of Nebulized BromAc on Rheology of Artificial Sputum: Relevance to Muco-Obstructive Respiratory Diseases.
Pillai K, Mekkawy AH, Akhter J, Morris DL. Pillai K, et al. Adv Respir Med. 2023 Apr 14;91(2):146-163. doi: 10.3390/arm91020013. Adv Respir Med. 2023. PMID: 37102780 Free PMC article.
Respiratory diseases such as cystic fibrosis, COPD, and COVID-19 are difficult to treat owing to viscous secretions in the airways that evade mucocilliary clearance. ...The combination index using viscosity measurements showed synergy only with 250 g/mL bromelai …
Respiratory diseases such as cystic fibrosis, COPD, and COVID-19 are difficult to treat owing to viscous secretions in the air …
26 results