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Page 1
CD74 is a functional MIF receptor on activated CD4+ T cells.
Zhang L, Woltering I, Holzner M, Brandhofer M, Schaefer CC, Bushati G, Ebert S, Yang B, Muenchhoff M, Hellmuth JC, Scherer C, Wichmann C, Effinger D, Hübner M, El Bounkari O, Scheiermann P, Bernhagen J, Hoffmann A. Zhang L, et al. Cell Mol Life Sci. 2024 Jul 11;81(1):296. doi: 10.1007/s00018-024-05338-5. Cell Mol Life Sci. 2024. PMID: 38992165 Free PMC article.
Here, we characterized the regulation of CD74 expression and that of the MIF chemokine receptors during activation of human CD4(+) T cells and studied links to MIF-induced T-cell migration, function, and COVID-19 disease stage. MIF receptor profiling of resting prim …
Here, we characterized the regulation of CD74 expression and that of the MIF chemokine receptors during activation of human CD4(+) T cells a …
Marine sulfated glycans inhibit the interaction of heparin with S-protein of SARS-CoV-2 Omicron XBB variant.
He P, Song Y, Jin W, Li Y, Xia K, Kim SB, Dwivedi R, Farrag M, Bates J, Pomin VH, Wang C, Linhardt RJ, Dordick JS, Zhang F. He P, et al. Glycoconj J. 2024 Apr;41(2):163-174. doi: 10.1007/s10719-024-10150-1. Epub 2024 Apr 20. Glycoconj J. 2024. PMID: 38642280
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide COVID-19 pandemic, leading to 6.8 million deaths. Numerous variants have emerged since its outbreak, resulting in its significantly enhanced ability to sprea …
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide COVID-19 pandemic …
Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease.
Smith MM, Melrose J. Smith MM, et al. Int J Mol Sci. 2024 Feb 29;25(5):2825. doi: 10.3390/ijms25052825. Int J Mol Sci. 2024. PMID: 38474072 Free PMC article. Review.
Recent findings show lumican has novel roles as a biomarker of the hypercoagulative state that occurs in SARS CoV-2 infections; thus, it may also prove useful in the delineation of the complex tissue changes that characterize COVID-19 disease. L …
Recent findings show lumican has novel roles as a biomarker of the hypercoagulative state that occurs in SARS CoV-2 inf …
SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK.
Bhattacharyya S, Tobacman JK. Bhattacharyya S, et al. Signal Transduct Target Ther. 2024 Feb 14;9(1):39. doi: 10.1038/s41392-024-01741-3. Signal Transduct Target Ther. 2024. PMID: 38355690 Free PMC article.
Immunostaining in lungs of patients who died with COVID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase (Arylsulfatase B; ARSB). To explain these findings, human small airway ep …
Immunostaining in lungs of patients who died with COVID-19 infection showed increased intensity and distribution of chondro …
The Sea Cucumber Thyonella gemmata Contains a Low Anticoagulant Sulfated Fucan with High Anti-SARS-CoV-2 Actions against Wild-Type and Delta Variants.
Dwivedi R, Farrag M, Sharma P, Shi D, Shami AA, Misra SK, Ray P, Shukla J, Zhang F, Linhardt RJ, Sharp JS, Tandon R, Pomin VH. Dwivedi R, et al. J Nat Prod. 2023 Jun 23;86(6):1463-1475. doi: 10.1021/acs.jnatprod.3c00151. Epub 2023 Jun 12. J Nat Prod. 2023. PMID: 37306476 Free PMC article.
Inhibitory properties of TgFucCS and TgSF were investigated using SARS-CoV-2 pseudovirus coated with S-proteins of the wild-type (Wuhan-Hu-1) or the delta (B.1.617.2) strains and in four different anticoagulant assays, comparatively with unfractionated hepari …
Inhibitory properties of TgFucCS and TgSF were investigated using SARS-CoV-2 pseudovirus coated with S-proteins of the …
Structural requirements of Holothuria floridana fucosylated chondroitin sulfate oligosaccharides in anti-SARS-CoV-2 and anticoagulant activities.
Farrag M, Dwivedi R, Sharma P, Kumar D, Tandon R, Pomin VH. Farrag M, et al. PLoS One. 2023 May 11;18(5):e0285539. doi: 10.1371/journal.pone.0285539. eCollection 2023. PLoS One. 2023. PMID: 37167245 Free PMC article.
Activated partial thromboplastin time and assays using protease (factors Xa and IIa) and serine protease inhibitors (antithrombin, and heparin cofactor II) in the presence of the sulfated carbohydrates were used to monitor anticoagulation. Anti-SARS-CoV-2 eff …
Activated partial thromboplastin time and assays using protease (factors Xa and IIa) and serine protease inhibitors (antithrombin, and hepar …
Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses.
Zoepfl M, Dwivedi R, Kim SB, McVoy MA, Pomin VH. Zoepfl M, et al. Sci Rep. 2023 Mar 23;13(1):4804. doi: 10.1038/s41598-023-31722-5. Sci Rep. 2023. PMID: 36959228 Free PMC article.
In the current work we used pseudotyped lentivirus particles to investigate in a comparative fashion the inhibitory properties of five structurally defined MSGs against SARS-CoV-1, SARS-CoV-2, MERS-CoV, and influenza A virus (IAV). MSGs include the disacchari …
In the current work we used pseudotyped lentivirus particles to investigate in a comparative fashion the inhibitory properties of five struc …
Glucocorticoid Effects on Proteoglycans and Glycosaminoglycans.
Strokotova AV, Grigorieva EV. Strokotova AV, et al. Int J Mol Sci. 2022 Dec 10;23(24):15678. doi: 10.3390/ijms232415678. Int J Mol Sci. 2022. PMID: 36555315 Free PMC article. Review.
They are actively used to treat a wide variety of diseases, including neurodegenerative and inflammatory diseases, cancers, and COVID-19, among others. However, the long-term use of glucocorticoids is associated with numerous side effects. ...
They are actively used to treat a wide variety of diseases, including neurodegenerative and inflammatory diseases, cancers, and COVID …
Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome.
Kiselevskiy MV, Anisimova NY, Bilan MI, Usov AI, Ustyuzhanina NE, Petkevich AA, Shubina IZ, Morozevich GE, Nifantiev NE. Kiselevskiy MV, et al. Russ J Bioorg Chem. 2022;48(6):1109-1122. doi: 10.1134/S1068162022060152. Epub 2022 Oct 29. Russ J Bioorg Chem. 2022. PMID: 36325402 Free PMC article.
Symptoms of the new coronavirus infection that appeared in 2019 (COVID-19) range from low fever and fatigue to acute pneumonia and multiple organ failure. ...The choice of the treatment strategy for post-COVID-19 syndrome is still a challenge to be res …
Symptoms of the new coronavirus infection that appeared in 2019 (COVID-19) range from low fever and fatigue to acute pneumonia …
Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures.
Dwivedi R, Sharma P, Eilts F, Zhang F, Linhardt RJ, Tandon R, Pomin VH. Dwivedi R, et al. Glycobiology. 2023 Jan 8;33(1):75-85. doi: 10.1093/glycob/cwac063. Glycobiology. 2023. PMID: 36136750 Free PMC article.
The PpFucCS-derived oligosaccharide fraction of the highest MW showed great anti-SARS-CoV-2 Delta activity and reduced anticoagulant properties. Results have indicated no cytotoxicity and MW dependency on both anti-SARS-CoV-2 and anticoag …
The PpFucCS-derived oligosaccharide fraction of the highest MW showed great anti-SARS-CoV-2 Delta activity and reduced …
26 results