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Discovery and characterization of naturally occurring covalent inhibitors of SARS-CoV-2 M(pro) from the antiviral herb Ephedra.
Hu Q, Zhang Y, Chen P, Zhang Y, Zhu G, Liu W, Wang C, Zheng S, Shen N, Wang H, Huang P, Ge G. Hu Q, et al. Chin J Nat Med. 2024 Sep;22(9):797-807. doi: 10.1016/S1875-5364(24)60577-7. Chin J Nat Med. 2024. PMID: 39326974
This study aimed to identify naturally occurring covalent inhibitors of SARS-CoV-2 M(pro) from Ephedra and to investigate their covalent binding sites. The results demonstrated that the non-alkaloid fraction of Ephedra (ENA) exhibited a potent i …
This study aimed to identify naturally occurring covalent inhibitors of SARS-CoV-2 M(pro) from Ephedra and to in …
In vitro anti-severe acute respiratory syndrome coronavirus 2 effect of Ephedra przewalskii Stapf extract.
Kakimoto M, Nomura T, Nazmul T, Yamamoto A, Sasaki H, Higashiura A, Ito M, Ohge H, Mikage M, Ogawa KO, Sakaguchi T. Kakimoto M, et al. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117341. doi: 10.1016/j.jep.2023.117341. Epub 2023 Oct 23. J Ethnopharmacol. 2024. PMID: 37879507 Free article.
AIM OF THE STUDY: We compared the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effects of E. przewalskii and E. sinica extracts in vitro. Additionally, we examined the differences in their antiviral effects against different SARS- …
AIM OF THE STUDY: We compared the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effects of E. przew …
Herbal combinations against COVID-19: A network pharmacology, molecular docking and dynamics study.
Song JB, Zhao LQ, Wen HP, Li YP. Song JB, et al. J Integr Med. 2023 Nov;21(6):593-604. doi: 10.1016/j.joim.2023.09.001. Epub 2023 Sep 26. J Integr Med. 2023. PMID: 37805293
OBJECTIVE: The aim of this study is to identify molecules from traditional Chinese medicine (TCM) with potential activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. METHODS: We applied the Apriori algorithm to ident …
OBJECTIVE: The aim of this study is to identify molecules from traditional Chinese medicine (TCM) with potential activity against severe acu …
The use of Ephedra herbs in the treatment of COVID-19.
Sadeghi Dousari A, Karimian Amroabadi M, Soofi Neyestani Z, Taati Moghadam M, Satarzadeh N. Sadeghi Dousari A, et al. Avicenna J Phytomed. 2023 May-Jun;13(3):231-239. doi: 10.22038/AJP.2022.21607. Avicenna J Phytomed. 2023. PMID: 37654998 Free PMC article. Review.
On the other hand, because the coronavirus disease 2019 (COVID-19) causes respiratory problems and COVID-19 pandemic is the most widespread outbreak that has affected humanity in the last century, the current review aims using literature search to inve …
On the other hand, because the coronavirus disease 2019 (COVID-19) causes respiratory problems and COVID-19 pand …
Antiviral Effect of Ephedrine Alkaloids-Free Ephedra Herb Extract against SARS-CoV-2 In Vitro.
Uema M, Hyuga M, Yonemitsu K, Hyuga S, Amakura Y, Uchiyama N, Mizoguchi K, Odaguchi H, Goda Y. Uema M, et al. Microorganisms. 2023 Feb 20;11(2):534. doi: 10.3390/microorganisms11020534. Microorganisms. 2023. PMID: 36838499 Free PMC article.
We report for the first time that ephedrine alkaloids-free Ephedra Herb extract (EFE) directly inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and that the addition of EFE to the culture medium before v …
We report for the first time that ephedrine alkaloids-free Ephedra Herb extract (EFE) directly inhibits the replication of severe acu …
Ephedrae Herba: A Review of Its Phytochemistry, Pharmacology, Clinical Application, and Alkaloid Toxicity.
Tang S, Ren J, Kong L, Yan G, Liu C, Han Y, Sun H, Wang XJ. Tang S, et al. Molecules. 2023 Jan 9;28(2):663. doi: 10.3390/molecules28020663. Molecules. 2023. PMID: 36677722 Free PMC article. Review.
Ephedrae Herba (Ephedra), known as "MaHuang" in China, is the dried straw stem that is associated with the lung and urinary bladder meridians. ...This herb has long been used to treat asthma, liver disease, skin disease, and other diseases, and has shown unique effi …
Ephedrae Herba (Ephedra), known as "MaHuang" in China, is the dried straw stem that is associated with the lung and urinary bl …
Network Pharmacological Analysis on the Herbal Combinations for Mitigating Inflammation in Respiratory Tracts and Experimental Evaluation.
Jang D, Lee MJ, Kim KS, Kim CE, Jung JH, Cho M, Hong BH, Park SJ, Kang KS. Jang D, et al. Healthcare (Basel). 2023 Jan 3;11(1):143. doi: 10.3390/healthcare11010143. Healthcare (Basel). 2023. PMID: 36611603 Free PMC article.
The regulation of inflammatory mediators, such as TNF-alpha, IL-6, IL-1beta, and leukotriene B4, could play a crucial role in suppressing inflammatory diseases such as COVID-19. In this study, we investigated the potential mechanisms of drug combinations comprising …
The regulation of inflammatory mediators, such as TNF-alpha, IL-6, IL-1beta, and leukotriene B4, could play a crucial role in suppressing in …
Herbal medicines exhibit a high affinity for ACE2 in treating COVID-19.
Zhang B, Qi F. Zhang B, et al. Biosci Trends. 2023 Mar 11;17(1):14-20. doi: 10.5582/bst.2022.01534. Epub 2023 Jan 2. Biosci Trends. 2023. PMID: 36596560 Free article.
Coronavirus Disease 2019 (COVID-19) has been an unprecedented disaster for people around the world. A point particularly worth noting is that herbal medicines have made great contributions to the prevention and treatment of COVID-19 in China. ...Theref …
Coronavirus Disease 2019 (COVID-19) has been an unprecedented disaster for people around the world. A point particularly worth …
Application of Jiawei Maxing Shigan Tang in the treatment of COVID-19: An observational study.
Wu J, Tang F, Zhang XQ, Fu ZL, Fu S. Wu J, et al. Front Med (Lausanne). 2022 Oct 20;9:1028171. doi: 10.3389/fmed.2022.1028171. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36341261 Free PMC article.
OBJECTIVE: To explore the clinical efficacy and adverse reactions of Jiawei Maxing Shigan Tang (JMST; a modified decoction of ephedra, apricot kernel, gypsum, and licorice) combined with western medicine in the symptomatic treatment of COVID-19. ...CONCLUSION …
OBJECTIVE: To explore the clinical efficacy and adverse reactions of Jiawei Maxing Shigan Tang (JMST; a modified decoction of ephedra …
[Medication law and mechanism of traditional Chinese medicine in prevention and treatment of epidemic diseases: based on traditional Chinese medicine theory of cold pestilence].
Li ZY, Hao EW, Cao R, Lin S, Chen SY, Huang XT, Xu WR, Hou XT, Deng JG. Li ZY, et al. Zhongguo Zhong Yao Za Zhi. 2022 Sep;47(17):4765-4777. doi: 10.19540/j.cnki.cjcmm.20220528.501. Zhongguo Zhong Yao Za Zhi. 2022. PMID: 36164884 Chinese.
Particularly, the the relationship of coronavirus disease 2019(COVID-19), severe acute respiratory syndrome(SARS), and influenza A(H1 N1) with the cold pestilence was identified and analyzed. ...It was determined that the key targets were tumor necrosis factor(TNF), …
Particularly, the the relationship of coronavirus disease 2019(COVID-19), severe acute respiratory syndrome(SARS), and influen …
39 results