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2020 16
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137 results

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Dual-Mechanism mRNA Delivery via Fluorinated-Sorbitol Polyplexes: Enhancing Cellular Uptake and Endosomal Escape for COVID-19 Vaccination.
Vasukutty A, Chahal S, Lee KH, Park SH, Kim SM, Shin E, Kim YJ, Kim D, Lee JA, Jeong HS, Park IK. Vasukutty A, et al. Adv Healthc Mater. 2024 Dec 26:e2403374. doi: 10.1002/adhm.202403374. Online ahead of print. Adv Healthc Mater. 2024. PMID: 39723670
Additionally, intramuscular administration of the SARS-CoV-2 spike mRNA vaccine elicited robust immune responses comparable to Moderna's LNP formulation. The vaccine effectively neutralized the Wuhan variant strain of SARS-CoV-2, as shown …
Additionally, intramuscular administration of the SARS-CoV-2 spike mRNA vaccine elicited robust immune responses compar …
F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution.
Zhang Q, Yin W, Chen X, Zhou A, Zhang G, Zhao Z, Li Z, Zhang Y, Bunu SJ, Shen J, Zhu W, Jiang X, Xu Z. Zhang Q, et al. J Med Chem. 2025 Jan 9;68(1):706-718. doi: 10.1021/acs.jmedchem.4c02668. Epub 2024 Dec 20. J Med Chem. 2025. PMID: 39707149
In this study, we constructed a data set with 111,168 pairs of fluorine-substituted and nonfluorine-substituted compounds. We developed a multimodal deep learning model (F-CPI). ...The application of the F-CPI for the structural optimization of hit compounds against SAR …
In this study, we constructed a data set with 111,168 pairs of fluorine-substituted and nonfluorine-substituted compounds. We develop …
2'-Fluorinated nucleoside chemistry for new drug discovery: achievements and prospects.
Meng Y, Sun N, Liang L, Yu B, Chang J. Meng Y, et al. Natl Sci Rev. 2024 Oct 1;11(10):nwae331. doi: 10.1093/nsr/nwae331. eCollection 2024 Oct. Natl Sci Rev. 2024. PMID: 39526027 Free PMC article. Review.
Many fluorinated nucleosides have advanced into clinical trials or have been approved by the FDA for use in patients. Among these fluorinated nucleosides, azvudine, developed by us, has been officially approved by the National Medical Products Administration for the …
Many fluorinated nucleosides have advanced into clinical trials or have been approved by the FDA for use in patients. Among these …
In silico evaluation of favipiravir-associated potential new drugs against polymerase enzyme of SARS-CoV-2.
Saira, Khan K, Khan A, Khan A, Shah T, Ahmad N, Rashid HU, Zahoor M, Ullah R, Bari A, Umar MN. Saira, et al. Heliyon. 2024 Sep 26;10(19):e38479. doi: 10.1016/j.heliyon.2024.e38479. eCollection 2024 Oct 15. Heliyon. 2024. PMID: 39398000 Free PMC article.
Millions of lives have been lost to the deadly SARS-CoV-2 virus. Vaccines and antiviral drugs are essential scientific tools in combating viral infections. ...This theoretical study suggests that ligands L6 and L7 could serve as lead candidates for RdRp inhib …
Millions of lives have been lost to the deadly SARS-CoV-2 virus. Vaccines and antiviral drugs are essential scientific …
Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity.
Sanislav O, Tetaj R, Metali, Ratcliffe J, Phillips W, Klein AR, Sethi A, Zhou J, Mezzenga R, Saxer SS, Charnley M, Annesley SJ, Reynolds NP. Sanislav O, et al. Nanoscale. 2024 Oct 31;16(42):19814-19827. doi: 10.1039/d4nr03030c. Nanoscale. 2024. PMID: 39363846
The neurological symptoms of COVID-19, often referred to as neuro-COVID include neurological pain, memory loss, cognitive and sensory disruption. These neurological symptoms can persist for months and are known as Post-Acute Sequalae of COVID-19 …
The neurological symptoms of COVID-19, often referred to as neuro-COVID include neurological pain, memory loss, cogniti …
Expanding the tool box for native structural biology: 19F dynamic nuclear polarization with fast magic angle spinning.
Movellan KT, Zhu W, Banks D, Kempf J, Runge B, Gronenborn AM, Polenova T. Movellan KT, et al. Sci Adv. 2024 Oct 4;10(40):eadq3115. doi: 10.1126/sciadv.adq3115. Epub 2024 Oct 2. Sci Adv. 2024. PMID: 39356759 Free PMC article.
High signal-to-noise ratio spectra were acquired on nanomole quantities of a protein in cells in minutes. 2D (19)F-(19)F dipolar correlation spectra with remarkable sensitivity and resolution were obtained, exhibiting (19)F-(19)F cross peaks associated with fluorine atoms …
High signal-to-noise ratio spectra were acquired on nanomole quantities of a protein in cells in minutes. 2D (19)F-(19)F dipolar correlation …
Subcutaneous adipose tissue radiodensity: An emerging risk factor for severe COVID-19.
Padilha DMH, Mendes MCS, Takahashi MES, Lascala F, Silveira MN, Pozzuto L, Carrilho LAO, Guerra LD, Moreira RCL, Branbilla SR, Ramos CD, Carvalheira JBC. Padilha DMH, et al. Nutrition. 2024 Dec;128:112561. doi: 10.1016/j.nut.2024.112561. Epub 2024 Aug 20. Nutrition. 2024. PMID: 39277984
BACKGROUND: Adipose tissue radiodensity and metabolic activity may influence COVID-19 outcomes. This study evaluated the association between adipose tissue characteristics and clinical outcomes in COVID-19 patients. METHODS: Two retrospective cohorts o …
BACKGROUND: Adipose tissue radiodensity and metabolic activity may influence COVID-19 outcomes. This study evaluated the assoc …
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2.
Ong HW, Yang X, Smith JL, Taft-Benz S, Howell S, Dickmander RJ, Havener TM, Sanders MK, Brown JW, Couñago RM, Chang E, Krämer A, Moorman NJ, Heise M, Axtman AD, Drewry DH, Willson TM. Ong HW, et al. Molecules. 2024 Sep 2;29(17):4158. doi: 10.3390/molecules29174158. Molecules. 2024. PMID: 39275006 Free PMC article.
Inhibitors based on the pyrazolo[1,5-a]pyrimidine scaffold possess outstanding potency and selectivity for CSNK2, but bioavailability and metabolic stability are often challenging. By strategically installing a fluorine atom on an electron-rich phenyl ring of a previously …
Inhibitors based on the pyrazolo[1,5-a]pyrimidine scaffold possess outstanding potency and selectivity for CSNK2, but bioavailability and me …
COVID-19 pneumonia incidentally discovered on [18F]F-PSMA-1007 PET/CT scan.
El Moatassim I, Ait Sahel O, Bouzidi K, Oueriagli SN, Benameur Y, El Bakkali J, Doudouh A. El Moatassim I, et al. Nucl Med Rev Cent East Eur. 2024;27(0):28-30. doi: 10.5603/nmr.101021. Nucl Med Rev Cent East Eur. 2024. PMID: 39162351 Free article.
CT images revealed ground-glass opacities and a reticular pattern, suggesting COVID-19 pneumonia, which was confirmed by reverse transcription polymerase chain reaction (RT-PCR). ...In this case, the probable lung angiogenesis linked to COVID-19 infect …
CT images revealed ground-glass opacities and a reticular pattern, suggesting COVID-19 pneumonia, which was confirmed by rever …
Development of radiofluorinated MLN-4760 derivatives for PET imaging of the SARS-CoV-2 entry receptor ACE2.
Wang J, Beyer D, Vaccarin C, He Y, Tanriver M, Benoit R, Deupi X, Mu L, Bode JW, Schibli R, Müller C. Wang J, et al. Eur J Nucl Med Mol Imaging. 2024 Dec;52(1):9-21. doi: 10.1007/s00259-024-06831-6. Epub 2024 Jul 27. Eur J Nucl Med Mol Imaging. 2024. PMID: 39066808 Free PMC article.
PURPOSE: The angiotensin converting enzyme 2 (ACE2) plays a regulatory role in the cardiovascular system and serves SARS-CoV-2 as an entry receptor. The aim of this study was to synthesize and evaluate radiofluorinated derivatives of the ACE2 inhibitor MLN-47 …
PURPOSE: The angiotensin converting enzyme 2 (ACE2) plays a regulatory role in the cardiovascular system and serves SARS-CoV- …
137 results