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Page 1
Impact of Single Halogen Atom Substitutions on Antiviral Profile of Inhibitors Targeting SARS-CoV-2 Main Protease.
Bulut H, Higashi-Kuwata N, Ogata-Aoki H, Hayashi H, Takamune N, Kishimoto N, Das D, Li M, Wlodawer A, Misumi S, Tamamura H, Mitsuya H. Bulut H, et al. ACS Omega. 2026 Jan 14;11(3):4541-4550. doi: 10.1021/acsomega.5c10895. eCollection 2026 Jan 27. ACS Omega. 2026. PMID: 41626465 Free PMC article.
The SARS-CoV-2 main protease (M(pro)) remains a prime antiviral target because its inhibition halts viral replication. ...High-resolution X-ray structures (1.6-1.8 A) explain the dichotomy: small halogens fit snugly in the S1' sigma-hole pocket, maximizing hy …
The SARS-CoV-2 main protease (M(pro)) remains a prime antiviral target because its inhibition halts viral replication. …
Absorption, distribution, metabolism, and excretion tactics toward the expedited discovery and development of the severe acute respiratory syndrome coronavirus-2 main protease inhibitor nirmatrelvir.
Kalgutkar AS, Eng H, Dantonio AL, Kadar EP, Di L, Walker GS, Boras B, Obach RS. Kalgutkar AS, et al. Drug Metab Dispos. 2025 Dec 23;54(2):100226. doi: 10.1016/j.dmd.2025.100226. Online ahead of print. Drug Metab Dispos. 2025. PMID: 41558303 Review.
The review also delves into a discussion around the successful use of quantitative fluorine-19 nuclear magnetic resonance spectroscopy in the characterization of the human mass balance and excretion pathways of nirmatrelvir. ...SIGNIFICANCE STATEMENT: This perspective disc …
The review also delves into a discussion around the successful use of quantitative fluorine-19 nuclear magnetic resonance spectroscop …
Design and synthesis of dual-activity biphenyl inhibitors against SARS-CoV-2 and bladder cancer.
Shang LL, Hu TL, Xiong S, Xu S, Cheng LP. Shang LL, et al. Eur J Med Chem. 2026 Mar 15;306:118581. doi: 10.1016/j.ejmech.2026.118581. Epub 2026 Jan 13. Eur J Med Chem. 2026. PMID: 41558060
Targeting the crucial SARS-CoV-2 therapeutic target 3CL(pro), a natural product MOL007703 was identified from Stellariae Radix. ...L3 also exhibits potent antiviral activity against SARS-CoV-2 (EC(50) = 2.82 muM), comparable to remdesivir …
Targeting the crucial SARS-CoV-2 therapeutic target 3CL(pro), a natural product MOL007703 was identified from Stellaria …
Investigation of the functional hot-spot residues of an enzyme by real-time monitoring of the enzymatic reaction using NMR and computational approaches.
Sugiki T, Yoshida T, Tsukamoto M, Miyanishi K, Kagawa A, Miura N, Ura T, Fukazawa J, Hatanaka Y, Murata T, Fujiwara T, Kitagawa M, Morita Y, Sakai-Kato K, Takakusagi Y, Tanaka N, Negoro M. Sugiki T, et al. Sci Rep. 2026 Jan 13;16(1):5896. doi: 10.1038/s41598-026-35354-3. Sci Rep. 2026. PMID: 41530325 Free PMC article.
SARS-CoV-2 Main Protease Inhibitors Containing 5-Substituted Benzothiazole-2-carbonyl Moieties at the P1' Site and Their Derivatives.
Tsuji K, Kobayakawa T, Higashi-Kuwata N, Ishii T, Shinohara K, Yamamoto R, Miura Y, Wada N, Mitsuya H, Tamamura H. Tsuji K, et al. ACS Omega. 2025 Aug 27;10(36):41608-41619. doi: 10.1021/acsomega.5c05168. eCollection 2025 Sep 16. ACS Omega. 2025. PMID: 40978346 Free PMC article.
Development of anti-SARS-CoV-2 agents is still required because of the appearance of drug-resistant strains, and targeting the main protease (M(pro)) of SARS-CoV-2 is a powerful way to develop therapeutics against COVID-19. …
Development of anti-SARS-CoV-2 agents is still required because of the appearance of drug-resistant strains, and target …
Fluorinated Graphene-Coated N95 Respirators for Enhanced Protection Against Viral Accumulation and Transmission.
He F, Zhang J, Zhai S, Liu C, Zhao H. He F, et al. Adv Eng Mater. 2025 Jul;27(13):10.1002/adem.202402919. doi: 10.1002/adem.202402919. Adv Eng Mater. 2025. PMID: 40927556 Free PMC article.
Highly contagious respiratory infection diseases such as COVID-19 can be transmitted by inhaling virus laden liquid droplets and short-range aerosols, released by an infected person. ...Furthermore, the ability against virus accumulation on the FG coated respirators …
Highly contagious respiratory infection diseases such as COVID-19 can be transmitted by inhaling virus laden liquid droplets a …
Noninvasive Monitoring of Inflammatory Processes by Myeloid Cell-Directed PET Tracers in an Experimental Severe Acute Respiratory Syndrome Coronavirus 2 Infection Model.
Stammes MA, Koopman G, Wagner TR, Traenkle B, Kaiser PD, Mooij P, van der Werff N, Acar RF, Böszörményi KP, Blaess S, Pezzana S, Reischl G, Maurer A, Langermans JAM, Rothbauer U, Kneilling M, Sonanini D. Stammes MA, et al. J Nucl Med. 2026 Jan 2;67(1):145-151. doi: 10.2967/jnumed.125.269721. J Nucl Med. 2026. PMID: 40876955 Free PMC article.
In this study, this PET tracer was used and validated to monitor the temporal dynamics of inflammatory processes during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in nonhuman primates. For further validation, the signal of [(64)Cu] …
In this study, this PET tracer was used and validated to monitor the temporal dynamics of inflammatory processes during severe acute respira …
Multi-Component Synthesis of New Fluorinated-Pyrrolo[3,4-b]pyridin-5-ones Containing the 4-Amino-7-chloroquinoline Moiety and In Vitro-In Silico Studies Against Human SARS-CoV-2.
Blanco-Carapia RE, Hernández-López R, Alcaraz-Estrada SL, Sarmiento-Silva RE, García-Hernández ME, Estrada-Toledo NV, Padilla-Bernal G, Herrera-Zúñiga LD, Garza J, Vargas R, González-Zamora E, Islas-Jácome A. Blanco-Carapia RE, et al. Int J Mol Sci. 2025 Aug 7;26(15):7651. doi: 10.3390/ijms26157651. Int J Mol Sci. 2025. PMID: 40806777 Free PMC article.
A one-pot synthetic methodology that combines an Ugi-Zhu three-component reaction (UZ-3CR) with a cascade sequence (intermolecular aza Diels-Alder cycloaddition/intramolecular N-acylation/decarboxylation/dehydration) using microwave-heating conditions, ytterbium (III) triflate (Y …
A one-pot synthetic methodology that combines an Ugi-Zhu three-component reaction (UZ-3CR) with a cascade sequence (intermolecular aza Diels …
Synthesis and Inhibitory Assessment of ACE2 Inhibitors for SARS-CoV-2: An In Silico and In Vitro Study.
Wang X, He J, Hosseini-Gerami L, Thomas M, Thompson S, Ford J, Ortalli S, Chen Z, Destro G, Bender A, Aigbirhio F, Gouverneur V. Wang X, et al. J Org Chem. 2025 Aug 1;90(30):10941-10947. doi: 10.1021/acs.joc.5c00918. Epub 2025 Jul 21. J Org Chem. 2025. PMID: 40686086 Free PMC article.
The angiotensin-converting enzyme 2 (ACE2) is pivotal as the cellular receptor for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the virus responsible for COVID-19. ...
The angiotensin-converting enzyme 2 (ACE2) is pivotal as the cellular receptor for SARS-CoV-2 (severe acute respiratory …
Critical aspects of droplet digital reverse transcription loop-mediated isothermal amplification (ddRT-LAMP) for viral pathogens detection.
Chávez-Ramos K, Trejo F, Salas-Navarrete PC, Ramón-Gallegos E, Muñoz-Medina JE, Alvarez-Icaza L, Olguin LF, Pilloni O, Oropeza-Ramos L. Chávez-Ramos K, et al. Microsyst Nanoeng. 2025 Jul 10;11(1):137. doi: 10.1038/s41378-025-00982-8. Microsyst Nanoeng. 2025. PMID: 40640128 Free PMC article.
The COVID-19 pandemic evidenced the urgent need for rapid, accurate, and scalable diagnostic methods for emerging infectious diseases. ...This study evaluates the critical conditions for effective ddRT-LAMP quantification of the SARS-CoV-2 N gen …
The COVID-19 pandemic evidenced the urgent need for rapid, accurate, and scalable diagnostic methods for emerging infectious d …
158 results