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Page 1
Manipulation of Host Cholesterol by SARS-CoV-2.
Doyle A, Goodson BA, Kolaczkowski OM, Liu R, Jia J, Wang H, Han X, Ye C, Bradfute SB, Kell AM, Lemus MR, Pu J. Doyle A, et al. bioRxiv [Preprint]. 2024 Nov 14:2024.11.13.623299. doi: 10.1101/2024.11.13.623299. bioRxiv. 2024. PMID: 39605369 Free PMC article. Preprint.
SARS-CoV-2 infection is associated with alterations in host lipid metabolism, including disruptions in cholesterol homeostasis. ...We further observed a marked reduction in bis(monoacylglycero)phosphate (BMP), a lipid essential for lysosomal cholesterol egres …
SARS-CoV-2 infection is associated with alterations in host lipid metabolism, including disruptions in cholesterol home …
Myelin basic protein antagonizes the SARS-CoV-2 protein ORF3a-induced autophagy inhibition.
Saratov GA, Belogurov AA Jr, Kudriaeva AA. Saratov GA, et al. Biochimie. 2024 Oct;225:1-9. doi: 10.1016/j.biochi.2024.04.011. Epub 2024 May 3. Biochimie. 2024. PMID: 38703943
Inhibition of autophagy is one of the hallmarks of the SARS-CoV-2 infection. Recently it was reported that SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes via interaction with VPS39 thus preventing binding of hom …
Inhibition of autophagy is one of the hallmarks of the SARS-CoV-2 infection. Recently it was reported that SARS- …
Emerging from the shadows: Trends in HIV ambulatory care, viral load testing, and viral suppression in a U.S. HIV cohort, 2019-2022: Impact of COVID-19 pandemic.
Tedaldi E, Hou Q, Armon C, Mahnken JD, Palella F FJ, Simoncini G, Fuhrer J, Mayer C, Ewing A, Chagaris K, Carlson KJ, Li J, Buchacz K. Tedaldi E, et al. J Investig Med. 2024 Oct;72(7):661-673. doi: 10.1177/10815589241252592. Epub 2024 May 27. J Investig Med. 2024. PMID: 38666457

This article aimed at analyzing the acute impact and the longer-term recovery of COVID-19 pandemic effects on clinical encounter types, HIV viral load (VL) testing, and suppression (HIV VL < 200 copies/mL). ...Ongoing recovery from the impact of COVID-1

…
This article aimed at analyzing the acute impact and the longer-term recovery of COVID-19 pandemic effects on clinical encount …
Mutual Aid Praxis Aligns Principles and Practice in Grassroots COVID-19 Responses Across the US.
Kenworthy N, Hops E, Hagopian A. Kenworthy N, et al. Kennedy Inst Ethics J. 2023 Jun;33(2):115-144. doi: 10.1353/ken.2023.a904080. Kennedy Inst Ethics J. 2023. PMID: 38468642 Free PMC article.
COVID-19 elicited a rapid emergence of new mutual aid networks in the US, but the practices of these networks are understudied. ...These findings underscore the importance of mutual aid praxis as an intersection between ethical principles and practices, and the chal …
COVID-19 elicited a rapid emergence of new mutual aid networks in the US, but the practices of these networks are understudied …
SARS-CoV-2 virulence factor ORF3a blocks lysosome function by modulating TBC1D5-dependent Rab7 GTPase cycle.
Walia K, Sharma A, Paul S, Chouhan P, Kumar G, Ringe R, Sharma M, Tuli A. Walia K, et al. Nat Commun. 2024 Mar 6;15(1):2053. doi: 10.1038/s41467-024-46417-2. Nat Commun. 2024. PMID: 38448435 Free PMC article.
SARS-CoV-2, the causative agent of COVID-19, uses the host endolysosomal system for entry, replication, and egress. Previous studies have shown that the SARS-CoV-2 virulence factor ORF3a interacts with the lysosomal tetherin …
SARS-CoV-2, the causative agent of COVID-19, uses the host endolysosomal system for entry, replication, a …
Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication.
Herzog AM, Göbel K, Marongiu L, Ruetalo N, Alonso MC, Leischner C, Busch C, Burkard M, Lauer UM, Geurink PP, Knobeloch KP, Schindler M, Fritz G, Venturelli S. Herzog AM, et al. Phytomedicine. 2024 Jan;123:155176. doi: 10.1016/j.phymed.2023.155176. Epub 2023 Oct 30. Phytomedicine. 2024. PMID: 37976697
Among them, the prenylated chalcone xanthohumol (XN) demonstrated to be a potent inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M(pro)). HYPOTHESIS/PURPOSE: Following the finding that xanthohumol (XN) is a potent …
Among them, the prenylated chalcone xanthohumol (XN) demonstrated to be a potent inhibitor of the severe acute respiratory syndrome coronavi …
Modulation of the replication of positive-sense RNA viruses by the natural plant metabolite xanthohumol and its derivatives.
Marongiu L, Burkard M, Helling T, Biendl M, Venturelli S. Marongiu L, et al. Crit Rev Food Sci Nutr. 2025;65(3):429-443. doi: 10.1080/10408398.2023.2275169. Epub 2023 Nov 9. Crit Rev Food Sci Nutr. 2025. PMID: 37942943 Review.
The COVID-19 pandemic has highlighted the importance of identifying new potent antiviral agents. ...As a result, the purpose of this review is to summarize the most recent research on the antiviral properties of XN and its derivatives, with a particular emphasis on …
The COVID-19 pandemic has highlighted the importance of identifying new potent antiviral agents. ...As a result, the purpose o …
Regulation of autophagy by SARS-CoV-2: The multifunctional contributions of ORF3a.
Shariq M, Malik AA, Sheikh JA, Hasnain SE, Ehtesham NZ. Shariq M, et al. J Med Virol. 2023 Jul;95(7):e28959. doi: 10.1002/jmv.28959. J Med Virol. 2023. PMID: 37485696 Review.
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) regulates autophagic flux by blocking the fusion of autophagosomes with lysosomes, causing the accumulation of membranous vesicles for replication. ...These mechanistic details can provide multiple …
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) regulates autophagic flux by blocking the fusion of autoph …
The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins.
Miller AN, Houlihan PR, Matamala E, Cabezas-Bratesco D, Lee GY, Cristofori-Armstrong B, Dilan TL, Sanchez-Martinez S, Matthies D, Yan R, Yu Z, Ren D, Brauchi SE, Clapham DE. Miller AN, et al. Elife. 2023 Jan 25;12:e84477. doi: 10.7554/eLife.84477. Elife. 2023. PMID: 36695574 Free PMC article.
We observe enrichment of the late endosomal marker Rab7 upon SARS-CoV-2 Orf3a overexpression, and co-immunoprecipitation with VPS39. Interestingly, SARS-CoV-1 Orf3a does not cause the same cellular phenotype as SARS-CoV-2 Orf3a and does n …
We observe enrichment of the late endosomal marker Rab7 upon SARS-CoV-2 Orf3a overexpression, and co-immunoprecipitatio …
Humulus lupus extract rich in xanthohumol improves the clinical course in critically ill COVID-19 patients.
Dabrowski W, Gagos M, Siwicka-Gieroba D, Piechota M, Siwiec J, Bielacz M, Kotfis K, Stepulak A, Grzycka-Kowalczyk L, Jaroszynski A, Malbrain ML. Dabrowski W, et al. Biomed Pharmacother. 2023 Feb;158:114082. doi: 10.1016/j.biopha.2022.114082. Epub 2022 Dec 9. Biomed Pharmacother. 2023. PMID: 36508996 Free PMC article. Clinical Trial.
BACKGROUND: The systemic inflammatory response following severe COVID-19 is associated with poor outcomes. Several anti-inflammatory medications have been studied in COVID-19 patients. ...CONCLUSION: Adjuvant therapy with Xn appears to be a promising a …
BACKGROUND: The systemic inflammatory response following severe COVID-19 is associated with poor outcomes. Several anti-inflam …
28 results