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The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery.
Novotný P, Humpolíčková J, Nováková V, Stanchev S, Stříšovský K, Zgarbová M, Weber J, Kryštůfek R, Starková J, Hradilek M, Moravcová A, Günterová J, Bach K, Majer P, Konvalinka J, Majerová T. Novotný P, et al. J Biol Chem. 2024 Dec 14;301(1):108079. doi: 10.1016/j.jbc.2024.108079. Online ahead of print. J Biol Chem. 2024. PMID: 39675720 Free article.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M(pro)) autocatalytically releases itself out of the viral polyprotein to form a fully active mature dimer in a manner that is not fully understood. ...Our findings help expand unders …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M(pro)) autocatalytically releases itself o …
Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.
Bilev E, Wild N, Momayyezi P, Sala BM, Sun R, Sandalova T, Marquardt N, Ljunggren HG, Achour A, Hammer Q. Bilev E, et al. PLoS Pathog. 2024 Dec 9;20(12):e1012755. doi: 10.1371/journal.ppat.1012755. eCollection 2024 Dec. PLoS Pathog. 2024. PMID: 39652590 Free PMC article.
In addition to adaptive immunity, natural killer (NK) cells of the innate immune system contribute to the control of viral infections. The HLA-E-restricted SARS-CoV-2 Nsp13232-240 epitope VMPLSAPTL renders infected cells susceptible to NK cells by preventing …
In addition to adaptive immunity, natural killer (NK) cells of the innate immune system contribute to the control of viral infections. The H …
Maple syrup urine disease diagnosed in a resource-limited setting in an infant in Nepal: a case report.
Baidya S, Thapa J, Kadel A, Kharal N, Lamichhane M, Dubey RK, Raut M, Bhattarai A, Tuladhar ET, Sharma VK, Niraula A. Baidya S, et al. BMC Pediatr. 2024 Nov 27;24(1):770. doi: 10.1186/s12887-024-05266-0. BMC Pediatr. 2024. PMID: 39604949 Free PMC article.
This case highlights MSUD diagnosed in association with COVID-19 complications from Nepal. CASE PRESENTATION: We present a case of a 4-month-old child with a biochemical diagnosis of flared-up MSUD. Initially presenting with chief complaints of fever, noisy breathin …
This case highlights MSUD diagnosed in association with COVID-19 complications from Nepal. CASE PRESENTATION: We present a cas …
Mutation of a highly conserved isoleucine residue in loop 2 of several beta-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free article.
To determine how the biochemical activities of these residues impact CoV replication, the isoleucine and the phenylalanine residues were mutated to alanine (I-A/F-A) in both recombinant Mac1 proteins and recombinant CoVs, including murine hepatitis virus, Middle East respi …
To determine how the biochemical activities of these residues impact CoV replication, the isoleucine and the phenylalanine residues w …
Metabolomic profiling of COVID-19 using serum and urine samples in intensive care and medical ward cohorts.
Tristán AI, Jiménez-Luna C, Abreu AC, Arrabal-Campos FM, Salmerón ADM, Rodríguez FI, Maresca MÁR, García AB, Melguizo C, Prados J, Fernández I. Tristán AI, et al. Sci Rep. 2024 Oct 10;14(1):23713. doi: 10.1038/s41598-024-74641-9. Sci Rep. 2024. PMID: 39390047 Free PMC article.
This study presents an NMR metabolomics-based approach, analysing 80 serum and urine samples from COVID-19 patients (34 intensive care patients and 46 hospitalized patients) and 32 from healthy controls. ...We propose a three-metabolite diagnostic panel-comprising …
This study presents an NMR metabolomics-based approach, analysing 80 serum and urine samples from COVID-19 patients (34 intens …
Cyclic-di-GMP induces inflammation and acute lung injury through direct binding to MD2.
Qian C, Zhu W, Wang J, Wang Z, Tang W, Liu X, Jin B, Xu Y, Zhang Y, Liang G, Wang Y. Qian C, et al. Clin Transl Med. 2024 Aug;14(8):e1744. doi: 10.1002/ctm2.1744. Clin Transl Med. 2024. PMID: 39166890 Free PMC article.
BACKGROUND: Severe bacterial infections can trigger acute lung injury (ALI) and acute respiratory distress syndrome, with bacterial pathogen-associated molecular patterns (PAMPs) exacerbating the inflammatory response, particularly in COVID-19 patients. Cyclic-di-GM …
BACKGROUND: Severe bacterial infections can trigger acute lung injury (ALI) and acute respiratory distress syndrome, with bacterial pathogen …
Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy.
Chao AS, Lin CY, Chiang MH, Lu KY, Tsai CK, Chen KJ, Chien CW, Wu TS, Chang YL, Chao A, Lin G, Chiu CY. Chao AS, et al. J Mol Med (Berl). 2024 Jun;102(6):819-830. doi: 10.1007/s00109-024-02438-4. Epub 2024 Apr 3. J Mol Med (Berl). 2024. PMID: 38568327
KEY MESSAGES : Anti-SARS-CoV-2 antibody titers decline as the number of days since COVID-19 vaccination increases. ...Amino acid metabolism is significantly associated with SARS-CoV-2 antibody titers....
KEY MESSAGES : Anti-SARS-CoV-2 antibody titers decline as the number of days since COVID-19 vaccination i …
Bio-Chemoinformatics-Driven Analysis of nsp7 and nsp8 Mutations and Their Effects on Viral Replication Protein Complex Stability.
Subong BJJ, Ozawa T. Subong BJJ, et al. Curr Issues Mol Biol. 2024 Mar 18;46(3):2598-2619. doi: 10.3390/cimb46030165. Curr Issues Mol Biol. 2024. PMID: 38534781 Free PMC article.
The nonstructural proteins 7 and 8 (nsp7 and nsp8) of SARS-CoV-2 are highly important proteins involved in the RNA-dependent polymerase (RdRp) protein replication complex. ...The most frequently occurring mutations for nsp7 which include L56F, L71F, S25L, M3I …
The nonstructural proteins 7 and 8 (nsp7 and nsp8) of SARS-CoV-2 are highly important proteins involved in the RNA-depe …
Mutation of a highly conserved isoleucine residue in loop 2 of several beta-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. bioRxiv [Preprint]. 2024 Jul 12:2024.01.03.574082. doi: 10.1101/2024.01.03.574082. bioRxiv. 2024. Update in: J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24 PMID: 38260573 Free PMC article. Updated. Preprint.
Within Mac1, there are several regions that are highly conserved across CoVs, including the GIF (glycine-isoleucine-phenylalanine) motif. To determine how the biochemical activities of these residues impact CoV replication, the isoleucine and the phenylalanine resid …
Within Mac1, there are several regions that are highly conserved across CoVs, including the GIF (glycine-isoleucine-phenylalanine) mo …
Metabolic alterations unravel the maternofetal immune responses with disease severity in pregnant women infected with SARS-CoV-2.
Hora S, Pahwa P, Siddiqui H, Saxena A, Kashyap M, Sevak JK, Singh R, Javed M, Yadav P, Kale P, Ramakrishna G, Bajpai M, Rathore A, Maras JS, Tyagi S, Sarin SK, Trehanpati N. Hora S, et al. J Med Virol. 2023 Dec;95(12):e29257. doi: 10.1002/jmv.29257. J Med Virol. 2023. PMID: 38054548
Pregnancy being an immune compromised state, coronavirus disease of 2019 (COVID-19) disease poses high risk of premature delivery and threat to fetus. Plasma metabolome regulates immune cellular responses, therefore we aimed to analyze the change in plasma secretome …
Pregnancy being an immune compromised state, coronavirus disease of 2019 (COVID-19) disease poses high risk of premature deliv …
35 results