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2020 3
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Page 1
Digitally enhanced ketogenic diet versus low-fat diet for cardio-renal-metabolic health in a predominantly Hispanic adult population with overweight or obesity: Pilot randomised clinical trial.
Du Y, Wang J, Li S, Meireles C, Saliba A, Castillo A, Goros M, Gelfond J, Choi BY, Qi L, Li C, Sharma K. Du Y, et al. Diabetes Obes Metab. 2025 Nov;27(11):6154-6166. doi: 10.1111/dom.70000. Epub 2025 Aug 6. Diabetes Obes Metab. 2025. PMID: 40770907 Free PMC article. Clinical Trial.
RESULTS: The study successfully enrolled the planned sample size (N = 60) within 1 year despite COVID-19-related challenges. Retention rates were 73.3% at 3 months and 71.7% at 6 months. ...HbA1c improved only in the ketogenic group (baseline: 6.0 0.9%; 3-month: 5.5 …
RESULTS: The study successfully enrolled the planned sample size (N = 60) within 1 year despite COVID-19-related challenges. R …
Causal Effects of Life-Course Adiposity and Metabolic Mediators on the Immune Response to COVID-19 Vaccination.
Liang P, Li C, Li Y, Xiong J, Mi J, Xiao P. Liang P, et al. J Med Virol. 2025 Aug;97(8):e70540. doi: 10.1002/jmv.70540. J Med Virol. 2025. PMID: 40751707
Despite adiposity's potential role in modulating immune responses, the causal effects of adiposity at different life stages on immune responses to COVID-19 vaccines remain poorly understood. Thus, we aimed to investigate the causal association between life-course ad …
Despite adiposity's potential role in modulating immune responses, the causal effects of adiposity at different life stages on immune respon …
A BSL-2 chimeric system designed to screen SARS-CoV-2 E protein ion channel inhibitors.
Negi V, Kuhn RJ. Negi V, et al. J Virol. 2025 May 20;99(5):e0225224. doi: 10.1128/jvi.02252-24. Epub 2025 Apr 30. J Virol. 2025. PMID: 40304492 Free PMC article.
The E protein is highly conserved among SARS-CoV-2 variants, making it an attractive target for antiviral therapies. Research on SARS-CoV-2 is restricted to BSL-3 laboratories, creating a bottleneck for screening potential antiviral compo …
The E protein is highly conserved among SARS-CoV-2 variants, making it an attractive target for antiviral therapies. Re …
Norovirus molecular trends in Harbin preschoolers Post-NPI easing.
Tian Y, Du X, Gao H, Yuan M, Wang Y, Shang L, Pan Y, Dong T, Zhang Z. Tian Y, et al. J Infect Public Health. 2025 May;18(5):102762. doi: 10.1016/j.jiph.2025.102762. Epub 2025 Mar 18. J Infect Public Health. 2025. PMID: 40154109 Free article.
This study aims to track changes in NoV genotype epidemiology before and after the lifting of COVID-19 non-pharmacological interventions (NPIs) in Harbin. METHODS: In this study, we investigated fecal samples collected by the Harbin Children's Hospital from attended …
This study aims to track changes in NoV genotype epidemiology before and after the lifting of COVID-19 non-pharmacological int …
Gut microbiota is associated with persistence of longer-term BNT162b2 vaccine immunogenicity.
Ng HY, Liao Y, Cheung CL, Zhang R, Chan KH, Seto WK, Leung WK, Hung IFN, Lam TTY, Cheung KS. Ng HY, et al. Front Immunol. 2025 Feb 27;16:1534787. doi: 10.3389/fimmu.2025.1534787. eCollection 2025. Front Immunol. 2025. PMID: 40083550 Free PMC article.
Blood samples were collected at baseline and day 180 after first dose, and tested for neutralizing antibodies (NAb) against receptor-binding domain (RBD) of wild type SARS-CoV-2 virus using chemiluminescence immunoassay. Shotgun DNA metagenomic sequencing was …
Blood samples were collected at baseline and day 180 after first dose, and tested for neutralizing antibodies (NAb) against receptor-binding …
The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery.
Novotný P, Humpolíčková J, Nováková V, Stanchev S, Stříšovský K, Zgarbová M, Weber J, Kryštůfek R, Starková J, Hradilek M, Moravcová A, Günterová J, Bach K, Majer P, Konvalinka J, Majerová T. Novotný P, et al. J Biol Chem. 2025 Jan;301(1):108079. doi: 10.1016/j.jbc.2024.108079. Epub 2024 Dec 14. J Biol Chem. 2025. PMID: 39675720 Free PMC article.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M(pro)) autocatalytically releases itself out of the viral polyprotein to form a fully active mature dimer in a manner that is not fully understood. ...Our findings help expand unders …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M(pro)) autocatalytically releases itself o …
Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.
Bilev E, Wild N, Momayyezi P, Sala BM, Sun R, Sandalova T, Marquardt N, Ljunggren HG, Achour A, Hammer Q. Bilev E, et al. PLoS Pathog. 2024 Dec 9;20(12):e1012755. doi: 10.1371/journal.ppat.1012755. eCollection 2024 Dec. PLoS Pathog. 2024. PMID: 39652590 Free PMC article.
In addition to adaptive immunity, natural killer (NK) cells of the innate immune system contribute to the control of viral infections. The HLA-E-restricted SARS-CoV-2 Nsp13232-240 epitope VMPLSAPTL renders infected cells susceptible to NK cells by preventing …
In addition to adaptive immunity, natural killer (NK) cells of the innate immune system contribute to the control of viral infections. The H …
Maple syrup urine disease diagnosed in a resource-limited setting in an infant in Nepal: a case report.
Baidya S, Thapa J, Kadel A, Kharal N, Lamichhane M, Dubey RK, Raut M, Bhattarai A, Tuladhar ET, Sharma VK, Niraula A. Baidya S, et al. BMC Pediatr. 2024 Nov 27;24(1):770. doi: 10.1186/s12887-024-05266-0. BMC Pediatr. 2024. PMID: 39604949 Free PMC article.
This case highlights MSUD diagnosed in association with COVID-19 complications from Nepal. CASE PRESENTATION: We present a case of a 4-month-old child with a biochemical diagnosis of flared-up MSUD. Initially presenting with chief complaints of fever, noisy breathin …
This case highlights MSUD diagnosed in association with COVID-19 complications from Nepal. CASE PRESENTATION: We present a cas …
Mutation of a highly conserved isoleucine residue in loop 2 of several beta-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free PMC article.
To determine how the biochemical activities of these residues impact CoV replication, the isoleucine and the phenylalanine residues were mutated to alanine (I-A/F-A) in both recombinant Mac1 proteins and recombinant CoVs, including murine hepatitis virus, Middle East respi …
To determine how the biochemical activities of these residues impact CoV replication, the isoleucine and the phenylalanine residues w …
Metabolomic profiling of COVID-19 using serum and urine samples in intensive care and medical ward cohorts.
Tristán AI, Jiménez-Luna C, Abreu AC, Arrabal-Campos FM, Salmerón ADM, Rodríguez FI, Maresca MÁR, García AB, Melguizo C, Prados J, Fernández I. Tristán AI, et al. Sci Rep. 2024 Oct 10;14(1):23713. doi: 10.1038/s41598-024-74641-9. Sci Rep. 2024. PMID: 39390047 Free PMC article.
This study presents an NMR metabolomics-based approach, analysing 80 serum and urine samples from COVID-19 patients (34 intensive care patients and 46 hospitalized patients) and 32 from healthy controls. ...We propose a three-metabolite diagnostic panel-comprising …
This study presents an NMR metabolomics-based approach, analysing 80 serum and urine samples from COVID-19 patients (34 intens …
40 results