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2020 64
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341 results

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Page 1
The impact of Covid-19 on harm reduction policies in Iran: an interrupted time series analysis.
Beiranvand S, Behzadifar M, Aryankhesal A, Ehsanzadeh SJ, Behzadifar M. Beiranvand S, et al. Harm Reduct J. 2025 Jan 7;22(1):3. doi: 10.1186/s12954-024-01137-0. Harm Reduct J. 2025. PMID: 39762842 Free PMC article.
BACKGROUND: The global emergence of the Covid-19 pandemic in 2019 posed unprecedented challenges to healthcare systems, disrupting routine services and necessitating swift adaptations. ...AIM: The study aims to assess the impact of the Covid-19 pandemi …
BACKGROUND: The global emergence of the Covid-19 pandemic in 2019 posed unprecedented challenges to healthcare systems, disrup …
Exploring pyrazolines as potential inhibitors of NSP3-macrodomain of SARS-CoV-2: synthesis and in silico analysis.
Joshi R, Gaikwad H, Soge B, Alshammari A, Albekairi NA, Kabra A, Yashwante U, Kolte B, Lokhande P, Meshram RJ. Joshi R, et al. Sci Rep. 2025 Jan 4;15(1):767. doi: 10.1038/s41598-024-81711-5. Sci Rep. 2025. PMID: 39755743 Free PMC article.
We identified the NSP3-microdomain (Mac-1) of SARS-CoV-2 as a putative target for newly synthesized triaryl-2-pyrazoline compounds. ...The detailed structural inspection of MD simulation trajectories sheds light on the structural and functional dynamics invol …
We identified the NSP3-microdomain (Mac-1) of SARS-CoV-2 as a putative target for newly synthesized triaryl-2-pyrazolin …
Social support status and associated factors among methadone maintenance patients: a multicentre, cross-sectional study in Vietnam during the COVID-19 pandemic.
Nguyen HTT, Tran DQ, Dinh DX. Nguyen HTT, et al. BMJ Open. 2024 Dec 27;14(12):e081519. doi: 10.1136/bmjopen-2023-081519. BMJ Open. 2024. PMID: 39732488 Free PMC article.
OBJECTIVES: To investigate the social support status and associated factors among Vietnamese methadone maintenance patients during the COVID-19 pandemic. DESIGN: Cross-sectional study. SETTING: Three methadone clinics. PARTICIPANTS: 540 patients. ...CONCLUSION: Meth …
OBJECTIVES: To investigate the social support status and associated factors among Vietnamese methadone maintenance patients during the CO …
Diagnosis, Severity, and Prognosis from Potential Biomarkers of COVID-19 in Urine: A Review of Clinical and Omics Results.
Narro-Serrano J, Marhuenda-Egea FC. Narro-Serrano J, et al. Metabolites. 2024 Dec 22;14(12):724. doi: 10.3390/metabo14120724. Metabolites. 2024. PMID: 39728505 Free PMC article. Review.
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has spurred an extraordinary scientific effort to better understand the disease's pathophysiology and develop diagnostic and prognostic tools to guide more precise and effective clinical man …
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has spurred an extraordinary scientific effort to …
Quantitative Assessment of Volatile Profile and Sensory Perception of Artisan Bread Made in the City of Valencia.
Sanmartín G, Sánchez-Adriá IE, Salvador A, Prieto JA, Estruch F, Randez-Gil F. Sanmartín G, et al. Foods. 2024 Nov 29;13(23):3872. doi: 10.3390/foods13233872. Foods. 2024. PMID: 39682944 Free PMC article.
Artisan bread, known for its simple recipes, natural ingredients, and traditional techniques, has seen a surge in demand, especially following the COVID-19 pandemic. Small bakeries emphasize extended fermentation processes and prioritize sensory qualities in their p …
Artisan bread, known for its simple recipes, natural ingredients, and traditional techniques, has seen a surge in demand, especially followi …
Methadone clinic staff perceptions of trauma-informed and patient-centered care: the role of individual staff characteristics.
Meyerson BE, Linde-Krieger LB, Carter GA, Huff AJ, Brady BR, Crosby RA, De La Rosa J, Allison A, Barakat M, Pava M, Schaefer M. Meyerson BE, et al. Addict Sci Clin Pract. 2024 Dec 1;19(1):87. doi: 10.1186/s13722-024-00501-6. Addict Sci Clin Pract. 2024. PMID: 39616394 Free PMC article.
BACKGROUND: U.S. policy intervention to increase methadone treatment accommodations during COVID did not result in national adoption of the new patient-centered treatment practices. ...
BACKGROUND: U.S. policy intervention to increase methadone treatment accommodations during COVID did not result in national adoption …
Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities.
Chen X, Li H, Wang M, Sun D, Lu J, Zhu T, Chen H, Chen L, Liu S. Chen X, et al. J Nat Prod. 2024 Dec 27;87(12):2680-2694. doi: 10.1021/acs.jnatprod.4c00657. Epub 2024 Nov 14. J Nat Prod. 2024. PMID: 39541564
Danshensu containing a catechol moiety has a moderate inhibitory effect on SARS-CoV-2 3CL(pro) (IC(50) = 2.2 muM) by a reversible covalent interaction and exhibits good anti-inflammatory activity. ...The resulting chalcone derivatives, A4 and A7, were found t …
Danshensu containing a catechol moiety has a moderate inhibitory effect on SARS-CoV-2 3CL(pro) (IC(50) = 2.2 muM) by a …
Personal care products use during SARS-CoV-2 pandemic: Environmental and public health impact assessment using wastewater-based epidemiology.
Ceolotto N, Jagadeesan K, Xu L, Standerwick R, Robertson M, Barden R, Barnett J, Kasprzyk-Hordern B. Ceolotto N, et al. Water Res. 2025 Jan 1;268(Pt A):122624. doi: 10.1016/j.watres.2024.122624. Epub 2024 Oct 17. Water Res. 2025. PMID: 39490091 Free article.
The recent SARS-CoV-2 pandemic had profound consequences on people's wellbeing, societies and economy worldwide. This manuscript discusses public exposure to chemicals of concern in personal care products (parabens and benzophenones) during SARS-CoV …
The recent SARS-CoV-2 pandemic had profound consequences on people's wellbeing, societies and economy worldwide. This m …
Denifanstat for the treatment of metabolic dysfunction-associated steatohepatitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2b trial.
Loomba R, Bedossa P, Grimmer K, Kemble G, Bruno Martins E, McCulloch W, O'Farrell M, Tsai WW, Cobiella J, Lawitz E, Rudraraju M, Harrison SA. Loomba R, et al. Lancet Gastroenterol Hepatol. 2024 Dec;9(12):1090-1100. doi: 10.1016/S2468-1253(24)00246-2. Epub 2024 Oct 11. Lancet Gastroenterol Hepatol. 2024. PMID: 39396529 Free article. Clinical Trial.
The most common treatment-emergent adverse events were COVID-19 (19 [17%] of 112 in the denifanstat group vs six [11%] of 56) in the placebo group, dry eye symptoms (ten [9%] of 112 vs eight [14%] of 56), and alopecia (21 [19%] of 112 vs two [4%] of 56). ...
The most common treatment-emergent adverse events were COVID-19 (19 [17%] of 112 in the denifanstat group vs six [11%] of 56) …
Design of novel and highly selective SARS-CoV-2 main protease inhibitors.
Poli ANR, Tietjen I, Nandwana NK, Cassel J, Messick TE, Register ET, Keeney F, Rajaiah R, Verma AK, Pandey K, Acharya A, Byrareddy SN, Montaner LJ, Salvino JM. Poli ANR, et al. Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0056224. doi: 10.1128/aac.00562-24. Epub 2024 Sep 3. Antimicrob Agents Chemother. 2024. PMID: 39225484 Free PMC article.
The lead prototype compound 1 (MPro IC(50) = 230 18 nM) also inhibits the replication of multiple SARS-CoV-2 variants in vitro, including SARS-CoV-2 variants of concern, and can synergize at lower concentrations with the viral RNA polymer …
The lead prototype compound 1 (MPro IC(50) = 230 18 nM) also inhibits the replication of multiple SARS-CoV-2 variants i …
341 results