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Spectroscopic investigation and structural simulation in human serum albumin with hydroxychloroquine/Silybum marianum and a possible potential COVID-19 drug candidate.
Tekyeh MSH, Shushtarian SMM, Bakhsh AI, Tackallou SH, Lanjanian H. Tekyeh MSH, et al. Arch Pharm (Weinheim). 2024 Jul;357(7):e2300751. doi: 10.1002/ardp.202300751. Epub 2024 Apr 21. Arch Pharm (Weinheim). 2024. PMID: 38644340
In this study, the interaction between human serum albumin (HSA) and the hydroxychloroquine/Silybum marianum (HCQ/SM) mixture was investigated using various techniques. The observed high binding constant (K(b)) and Stern-Volmer quenching constant (K(SV)) indicate a …
In this study, the interaction between human serum albumin (HSA) and the hydroxychloroquine/Silybum marianum (HCQ/SM) mixture …
Anti-Viral Activity of Bioactive Molecules of Silymarin against COVID-19 via In Silico Studies.
Zhang C, Sui Y, Liu S, Yang M. Zhang C, et al. Pharmaceuticals (Basel). 2023 Oct 17;16(10):1479. doi: 10.3390/ph16101479. Pharmaceuticals (Basel). 2023. PMID: 37895950 Free PMC article.
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection drove the global coronavirus disease 2019 (COVID-19) pandemic, causing a huge loss of human life and a negative impact on economic development. It is an urgent necessity …
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection drove the global coronavirus disease 2019 ( …
The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms.
Musazadeh V, Karimi A, Bagheri N, Jafarzadeh J, Sanaie S, Vajdi M, Karimi M, Niazkar HR. Musazadeh V, et al. Biomed Pharmacother. 2022 Oct;154:113593. doi: 10.1016/j.biopha.2022.113593. Epub 2022 Aug 22. Biomed Pharmacother. 2022. PMID: 36027611 Free PMC article. Review.
Like most other infectious diseases, inflammation, oxidative stress, and immune system dysfunctions play a pivotal role in the pathogenesis of COVID-19. Furthermore, the quest of finding a potential pharmaceutical therapy for preventing and treating COVID- …
Like most other infectious diseases, inflammation, oxidative stress, and immune system dysfunctions play a pivotal role in the pathogenesis …
Antiviral Efficacy of Selected Natural Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug Designing.
Aloufi BH, Snoussi M, Sulieman AME. Aloufi BH, et al. Molecules. 2022 Apr 8;27(8):2401. doi: 10.3390/molecules27082401. Molecules. 2022. PMID: 35458599 Free PMC article.
SARS-CoV-2 is a highly virulent coronavirus that first surfaced in late 2019 and has since created a pandemic of the acute respiratory sickness known as "coronavirus disease 2019" (COVID-19), posing a threat to human health and public safety. .. …
SARS-CoV-2 is a highly virulent coronavirus that first surfaced in late 2019 and has since created a pandemic of the ac …
Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions.
Koltai T, Fliegel L. Koltai T, et al. J Evid Based Integr Med. 2022 Jan-Dec;27:2515690X211068826. doi: 10.1177/2515690X211068826. J Evid Based Integr Med. 2022. PMID: 35018864 Free PMC article. Review.
Recently, it has also been proposed for SARS COVID-19 infection therapy. The biochemical and molecular mechanisms of action of these substances in cancer are subjects of ongoing research. ...The ample distribution and easy accessibility to milk thistle …
Recently, it has also been proposed for SARS COVID-19 infection therapy. The biochemical and molecular mechanisms of action of …
Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment.
Hanafy NAN, El-Kemary MA. Hanafy NAN, et al. Int J Biol Macromol. 2022 Feb 15;198:101-110. doi: 10.1016/j.ijbiomac.2021.12.073. Epub 2021 Dec 28. Int J Biol Macromol. 2022. PMID: 34968533 Free PMC article.
Respiratory infected by COVID-19 represents a major global health problem at moment even after recovery from virus corona. ...Additionally, encapsulating silymarin showed anti-viral activity in vitro COVID-19 experiment. It can be summarized that muco- …
Respiratory infected by COVID-19 represents a major global health problem at moment even after recovery from virus corona. ... …
Silibinin as potential tool against SARS-Cov-2: In silico spike receptor-binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects.
Speciale A, Muscarà C, Molonia MS, Cimino F, Saija A, Giofrè SV. Speciale A, et al. Phytother Res. 2021 Aug;35(8):4616-4625. doi: 10.1002/ptr.7107. Epub 2021 Apr 6. Phytother Res. 2021. PMID: 33822421 Free PMC article.
Thus, active molecules targeting multiple steps in SARS-CoV-2 lifecycle are highly wanted. Herein we explored the in silico capability of silibinin from Silybum marianum to interact with the SARS-CoV-2 main target proteins, …
Thus, active molecules targeting multiple steps in SARS-CoV-2 lifecycle are highly wanted. Herein we explored the in si …
SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome.
Sardanelli AM, Isgrò C, Palese LL. Sardanelli AM, et al. Molecules. 2021 Mar 5;26(5):1409. doi: 10.3390/molecules26051409. Molecules. 2021. PMID: 33807773 Free PMC article.
The causative agent was identified as a member of the Coronaviridae family, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, we present an analysis on the substances identified in the human metabolome capable of binding the …
The causative agent was identified as a member of the Coronaviridae family, called severe acute respiratory syndrome coronavirus 2 (SARS …