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The Antimicrobial Effects of Nitric Oxide: A Narrative Review.
Okda M, Spina S, Fakhr BS, Carroll RW. Okda M, et al. Nitric Oxide. 2025 Jan 8:S1089-8603(25)00001-1. doi: 10.1016/j.niox.2025.01.001. Online ahead of print. Nitric Oxide. 2025. PMID: 39793728 Review.
Nitric oxide (NO) is a versatile endogenous molecule with multiple physiological roles, including neurotransmission, vasodilation, and immune regulation. ...
Nitric oxide (NO) is a versatile endogenous molecule with multiple physiological roles, including neurotransmission, vasodilat …
Microvessels-on-chip: Exploring endothelial cells and COVID-19 plasma interaction with nitric oxide metabolites.
Pandian K, Postma R, van Zonneveld AJ, Harms A, Hankemeier T. Pandian K, et al. Nitric Oxide. 2025 Jan 7;155:12-19. doi: 10.1016/j.niox.2025.01.002. Online ahead of print. Nitric Oxide. 2025. PMID: 39788280 Free article.
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily manifests as a flu-like illness with lung injury, often necessitating supplemental oxygen. ...Endothelial dysfunction, characterized by impaired n …
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily manifests …
Effect of Alpinia officinarum Rhizome extract on experimentally induced lung fibrosis: The pertinent role of Sirt1 and Nrf2 antioxidant pathways.
Al-Gholam MAS, Abd-Elhafiz HI, Tayel SG. Al-Gholam MAS, et al. Morphologie. 2024 Dec 17;109(364):100940. doi: 10.1016/j.morpho.2024.100940. Online ahead of print. Morphologie. 2024. PMID: 39694016
BACKGROUND: Pulmonary fibrosis (PF) is a frequently reported COVID-19 sequela. It is a progressive disorder characterized by respiratory failure and death. ...However, AO extract significantly decreased histopathological injuries in hematoxylin & eosin, Masson's …
BACKGROUND: Pulmonary fibrosis (PF) is a frequently reported COVID-19 sequela. It is a progressive disorder characterized by r …
Inhaled Nitric Oxide Treatment of Early Pulmonary Hypertension to Reduce the Risk of Death or Bronchopulmonary Dysplasia in Infants Born Extremely Preterm: A Masked Randomized Controlled Trial.
Mirza H, Garcia J, Zussman M, Wadhawan R, Pepe J, Oh W. Mirza H, et al. J Pediatr. 2024 Dec 4;278:114427. doi: 10.1016/j.jpeds.2024.114427. Online ahead of print. J Pediatr. 2024. PMID: 39643111
OBJECTIVE: To determine whether inhaled nitric oxide (iNO) treatment of early pulmonary hypertension (PH) would decrease the risk of death or bronchopulmonary dysplasia (BPD) among infants born extremely preterm. STUDY DESIGN: This was a single-center, masked, rando …
OBJECTIVE: To determine whether inhaled nitric oxide (iNO) treatment of early pulmonary hypertension (PH) would decrease the r …
Congested heptacyclic meroterpenoids with anti-SARS-CoV-2 and anti-inflammatory activities from mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041.
Li J, Jia H, Chen C, An S, Yu J, Yuan J, Long Y, Li M. Li J, et al. Phytochemistry. 2025 Mar;231:114344. doi: 10.1016/j.phytochem.2024.114344. Epub 2024 Nov 28. Phytochemistry. 2025. PMID: 39613279
Bioassays revealed that amestolknoid C (3) exhibited excellent antiviral activity against SARS-CoV-2 with an EC(50) value of 2.50 muM and strong inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells with a …
Bioassays revealed that amestolknoid C (3) exhibited excellent antiviral activity against SARS-CoV-2 with an EC(50) val …
Potential Beneficial Role of Nitric Oxide in SARS-CoV-2 Infection: Beyond Spike-Binding Inhibition.
Sánchez-García S, Castrillo A, Boscá L, Prieto P. Sánchez-García S, et al. Antioxidants (Basel). 2024 Oct 26;13(11):1301. doi: 10.3390/antiox13111301. Antioxidants (Basel). 2024. PMID: 39594443 Free PMC article.
SARS-CoV-2, the causative virus for the COVID-19 disease, uses its spike glycoprotein to bind to human ACE2 as a first step for viral entry into the cell. ...These results support that it is worth considering NO as a therapeutic agent for COV …
SARS-CoV-2, the causative virus for the COVID-19 disease, uses its spike glycoprotein to bind to human AC …
Inactivation of Pseudovirus Expressing the D614G Spike Protein Mutation using Nitric Oxide-Plasma Activated Water.
Patel P, Kaushik N, Acharya TR, Lenka SS, Ghosh S, Wahab R, Verma SK, Choi EH, Kaushik NK. Patel P, et al. Adv Sci (Weinh). 2024 Dec;11(48):e2411515. doi: 10.1002/advs.202411515. Epub 2024 Nov 13. Adv Sci (Weinh). 2024. PMID: 39535372 Free PMC article.
Activated water neutralizes pathogens by damaging biological molecules; however, its effect on mutated SARS-CoV-2 or VOCs requires further exploration. Here, the efficacy of nitric oxide (NO(x))-plasma activated water (PAW) in inhibiting infecti …
Activated water neutralizes pathogens by damaging biological molecules; however, its effect on mutated SARS-CoV-2 or VO …
Dexamethasone-loaded chitosan-decorated PLGA nanoparticles: A step forward in attenuating the COVID-19 cytokine storm?
Costa MP, Abdu JOC, Machado Resende Guedes MC, Sarcinelli MA, Fabri RL, Pittella F, Macedo GC, Vilela FMP, Rocha HVA, Tavares GD. Costa MP, et al. Colloids Surf B Biointerfaces. 2025 Feb;246:114359. doi: 10.1016/j.colsurfb.2024.114359. Epub 2024 Nov 5. Colloids Surf B Biointerfaces. 2025. PMID: 39522287
This study aims to develop and characterize poly (lactic-co-glycolic acid) (PLGA) nanoparticles decorated with chitosan (CS) for the encapsulation of dexamethasone (DEX) (NP-DEX-CS), targeting improved efficacy in the treatment of severe acute respiratory syndrome (SARS) associat …
This study aims to develop and characterize poly (lactic-co-glycolic acid) (PLGA) nanoparticles decorated with chitosan (CS) for the encapsu …
An investigation into the contributing factors to survival of ARDS patients supported by veno-venous ECMO.
Majithia-Beet G, Naemi R, Issitt R. Majithia-Beet G, et al. Perfusion. 2024 Nov 6:2676591241297048. doi: 10.1177/02676591241297048. Online ahead of print. Perfusion. 2024. PMID: 39504499
INTRODUCTION: This study aimed to identify characteristics associated with survival during and post Extra Corporeal Membrane Oxygenation (ECMO) therapy, in patients with acute respiratory distress syndrome (ARDS) during the COVID-19 pandemic. METHODS: A retrospectiv …
INTRODUCTION: This study aimed to identify characteristics associated with survival during and post Extra Corporeal Membrane Oxygenation (EC …
Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS-CoV2-Induced Cytokine Storm. A Fluxomic Approach.
Sánchez-García S, Povo-Retana A, Marin S, Madurga S, Fariñas M, Aleixandre N, Castrillo A, de la Rosa JV, Alvarez-Lucena C, Landauro-Vera R, Prieto P, Cascante M, Boscá L. Sánchez-García S, et al. Adv Healthc Mater. 2025 Jan;14(1):e2401688. doi: 10.1002/adhm.202401688. Epub 2024 Nov 6. Adv Healthc Mater. 2025. PMID: 39502019 Free PMC article.
The cytokine storm associated with SARS-CoV-2 infection is one of the most distinctive pathological signatures in COVID-19 patients. ...These changes offer additional clues to understanding the potential crosstalk between NO and the COVID …
The cytokine storm associated with SARS-CoV-2 infection is one of the most distinctive pathological signatures in CO …
627 results